Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension.
Abstract
The aim of this study was to investigate the contribution of direct right-to-left ventricular interaction to left ventricular filling and stroke volume in 46 patients with pulmonary arterial hypertension (PAH) and 18 control subjects. Stroke volume, right and left ventricular volumes, left ventricular filling rate, and interventricular septum curvature were measured by magnetic resonance imaging and left atrial filling by transesophageal echocardiography. Stroke volume, left ventricular end-diastolic volume, and left ventricular peak filling rate were decreased in PAH patients compared with control subjects: 28 +/- 13 vs. 41 +/- 10 ml/m(2) (P < 0.001), 46 +/- 14 vs. 61 +/- 14 ml/m(2) (P < 0.001), and 216 +/- 90 vs. 541 +/- 248 ml/s (P < 0.001), respectively. Among PAH patients, stroke volume did not correlate to right ventricular end-diastolic volume or mean pulmonary arterial pressure but did correlate to left ventricular end-diastolic volume (r = 0.62, P < 0.001). Leftward interventricular septum curvature was correlated to left ventricular filling rate (r = 0.64, P < 0.001) and left ventricular end-diastolic volume (r = 0.65, P < 0.001). In contrast, left atrial filling was normal and not correlated to left ventricular end-diastolic volume. In PAH patients, ventricular interaction mediated by the interventricular septum impairs left ventricular filling, contributing to decreased stroke volume.
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In patients with pulmonary arterial hypertension, systolic/diastolic pulmonary artery pressure values can achieve 84.0 ± 23.0/37.0 ± 13.0 mmHg.
“whereas in patients with pulmonary arterial hypertension these values can achieve 84.0 ± 23.0/37.0 ± 13.0 mmHg (Gan et al., 2006).”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Gan et al., 2006
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Ventricular Geometry, Strain, and Rotational Mechanics in Pulmonary Hypertension
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Kutumova, E., Kiselev, I., Sharipov, R., Lifshits, G., & Kolpakov, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746300 · Cited by 16 · see citing works
- Authors
- Tji-Joong Gan, C., Lankhaar, J.-W., Marcus, J. T., Westerhof, N., Marques, K. M., Bronzwaer, J. G. F., Boonstra, A., Postmus, P. E., & Vonk-Noordegraaf, A.
- Affiliations
- Amsterdam Cardiovascular Sciences (NL)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2006-04
- Volume
- 290
- Issue
- 4
- Pages
- H1528-H1533
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2165885842
- Cited by
- 306
- References
- 30
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 14 · 2023: 12 · 2022: 14 · 2021: 21 · 2020: 15 · 2019: 12 · 2018: 24 · 2017: 17 · 2016: 19 · 2015: 22 · 2014: 15 · 2013: 24 · 2012: 19
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Keywords
- pulmonary arterial hypertension, left ventricular filling, stroke volume, left ventricular end-diastolic volume, left ventricular filling rate, left atrial filling, right ventricular end-diastolic volume
- MeSH terms
- Adult, Female, Humans, Hypertension, Pulmonary, Male, Middle Aged, Pulmonary Artery, Stroke Volume, Ventricular Dysfunction
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