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Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine
Abstract
Caffeine is thought to affect excitation-contraction coupling in cardiac muscle by activating the sarcoplasmic reticulum (SR) Ca2+-release channel. The effect of caffeine at the single channel level was studied by incorporating canine cardiac SR vesicles into planar lipid bilayers. Cardiac Ca2+-release channels were activated in a steady-state manner by millimolar cis-caffeine and displayed a unitary conductance (77 pS in 50 mM Ca2+ trans) similar to that previously observed for the Ca2+-activated cardiac channel. The caffeine-activated channel was moderately sensitive to the voltage applied across the bilayer, was sensitive to further activation by ATP, and was inhibited by Mg2+ and ruthenium red. Kinetic analysis showed that at low Ca2+ concentration, caffeine activated the channel by increasing the frequency and the duration of open events.
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Cited by
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Verkhratsky, A. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 709
Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms
Bassani, J. W., Bassani, R. A., & Bers, D. M. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020130 · Cited by 662
Györke, I., & Györke, S. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77723-9 · Cited by 396
Astroglial Excitability and Gliotransmission: An Appraisal of Ca 2+ as a Signalling Route
Zorec, R., Araque, A., Carmignoto, G., Haydon, P. G., Verkhratsky, A., & Parpura, V. (2012) · ASN Neuro · doi:10.1042/an20110061 · Cited by 264
Metadata
- Authors
- Rousseau, E., & Meissner, G.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1989-02-01
- Volume
- 256
- Issue
- 2
- Pages
- H328-H333
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2143955128
- Cited by
- 287
- References
- 0
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rousseau, E., & Meissner, G. (1989). Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.1989.256.2.h328
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