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Serial study of factors influencing changes in cardiac output during human pregnancy
Abstract
Serial hemodynamic measurements were performed in 13 women on two occasions before conception and then at monthly intervals throughout pregnancy. Cardiac output (CO) was measured by Doppler and cross-sectional echocardiography at the aortic, pulmonary, and mitral valves. Cardiac chamber size and ventricular function were investigated by M-mode echocardiography. CO increased from a mean of 4.88 l/min before the conception to a maximum of 7.21 l/min at 32 wk, the increase being significant by 5 wk after the last menstrual period. Heart rate and left ventricular performance increased during the first trimester. Heart rate increased further during the second trimester, during which left atrial and left ventricular end-diastolic dimensions increased, suggesting an increase in venous return. Derived values of total peripheral vascular resistance fell during the first 20 wk. These changes were associated with a progressive increase in valve orifice area and left ventricular wall thickness during pregnancy.
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Cited by
Abduljalil, K., Furness, P., Johnson, T. N., Rostami-Hodjegan, A., & Soltani, H. (2012) · Clinical Pharmacokinetics · doi:10.2165/11597440-000000000-00000 · Cited by 371
A longitudinal study of cardiac output in normal human pregnancy
Mabie, W. C., DiSessa, T. G., Crocker, L. G., Sibai, B. M., & Arheart, K. L. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(94)70297-7 · Cited by 310
Vascular biology of preeclampsia
Myatt, L., & Webster, R. P. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03259.x · Cited by 292
Morphological and Functional Adaptation of the Maternal Heart During Pregnancy
Savu, O., Jurcuţ, R., Giuşcă, S., van Mieghem, T., Gussi, I., Popescu, B. A., Ginghină, C., Rademakers, F., Deprest, J., & Voigt, J.-U. (2012) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.111.970012 · Cited by 285
Atrial Fibrillation or Flutter During Pregnancy in Patients With Structural Heart Disease
Salam, A. M., Ertekin, E., van Hagen, I. M., Al Suwaidi, J., Ruys, T. P. E., Johnson, M. R., Gumbiene, L., Frogoudaki, A. A., Sorour, K. A., Iserin, L., et al. (2015) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2015.04.013 · Cited by 79
Metadata
- Authors
- Robson, S. C., Hunter, S., Boys, R. J., & Dunlop, W.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1989-04-01
- Volume
- 256
- Issue
- 4
- Pages
- H1060-H1065
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2097408712
- Cited by
- 839
- References
- 0
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Serial study of factors influencing changes in cardiac output during human pregnancy. https://app.cochat.ai/papers/10.1152/ajpheart.1989.256.4.h1060
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- Robson, S. C., Hunter, S., Boys, R. J., & Dunlop, W. (1989). Serial study of factors influencing changes in cardiac output during human pregnancy. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.1989.256.4.h1060
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
