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Ischemic preconditioning protects against infarction in rat heart
Abstract
We examined the anti-infarct effect of ischemic preconditioning in the rat heart. All hearts were subjected to 30 min of regional coronary ischemia and 2 h of reperfusion. Infarct size was determined by tetrazolium. The control group had an average infarct size of 31% of the risk zone. Three 5-min cycles of preconditioning ischemia limited the infarct size to 3.7%. Neither the adenosine receptor blocker PD 115,199 nor the ATP-sensitive potassium channel blocker, glibenclamide, could block this protection. Intracoronary adenosine A1-receptor agonist 2-chloro-N6-cyclopentyladenosine offered a significant anti-infarct protection to the isolated rat heart, however. Although one 5-min cycle of preconditioning did not protect the rat heart from infarction (31% infarction in risk zone), it did attenuate arrhythmias. We conclude that 1) the rat heart can be preconditioned, which argues against mitochondrial adenosinetriphosphatase being the mechanism of preconditioning; 2) the threshold for preconditioning is higher in rat than rabbit or dog; 3) a role for adenosine in preconditioning was only partially supported; and 4) a role for ATP-sensitive potassium channels was not supported.
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Citations
Cited by
Kin, H. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.006 · Cited by 561
The role of mitochondria in protection of the heart by preconditioning
Halestrap, A. P., Clarke, S. J., & Khaliulin, I. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.05.008 · Cited by 390
Consequences of Brief Ischemia: Stunning, Preconditioning, and Their Clinical Implications: Part 2
Kloner, R. A., & Jennings, R. B. (2001) · Circulation · doi:10.1161/hc5001.100039 · Cited by 286
Mitochondrial KATP channels in preconditioning
Oldenburg, O. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00115-9 · Cited by 94
Metadata
- Authors
- Liu, Y., & Downey, J. M.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1992-10-01
- Volume
- 263
- Issue
- 4
- Pages
- H1107-H1112
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2109277649
- Cited by
- 352
- References
- 0
- FWCI
- 19.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, Y., & Downey, J. M. (1992). Ischemic preconditioning protects against infarction in rat heart. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.1992.263.4.h1107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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