Mitochondrial KATP channels in preconditioning

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

Murry, C. E., Jennings, R. B., & Reimer, K. A. (1986) · Circulation · doi:10.1161/01.cir.74.5.1124 · Cited by 7,813 · see citing works

Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.

Liu, G. S., Thornton, J. D., Winkle, D. M. V., Stanley, A., Olsson, R. A., & Downey, J. M. (1991) · Circulation · doi:10.1161/01.cir.84.1.350 · Cited by 1,351 · see citing works

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K+Channels

Garlid, K., Pauček, P., Yarov-Yarovoy, V. M., Murray, H. N., Darbenzio, R. B., DʼAlonzo, A. J., Lodge, N. J., Smith, M. A., & Grover, G. J. (1997) · Circulation Research · doi:10.1161/01.res.81.6.1072 · Cited by 1,019 · see citing works

Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs.

Gross, G. J., & Auchampach, J. A. (1992) · Circulation Research · doi:10.1161/01.res.70.2.223 · Cited by 953 · see citing works

Mitochondrial ATP-Dependent Potassium Channels

Liu, Y., Sato, T., O'Rourke, B. P., & Marbán, E. (1998) · Circulation · doi:10.1161/01.cir.97.24.2463 · Cited by 816 · see citing works

Opening of Mitochondrial K _ATP Channels Triggers the Preconditioned State by Generating Free Radicals

Pain, T., Yang, X.-M., Critz, S. D., Yue, Y., Nakano, A., Liu, G. S., Heusch, G., Cohen, M. V., & Downey, J. M. (2000) · Circulation Research · doi:10.1161/01.res.87.6.460 · Cited by 662 · see citing works

Signal characteristics of G protein‐transactivated EGF receptor

Daub, H., Wallasch, C., Lankenau, A., Herrlich, A., & Ullrich, A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.7032 · Cited by 647 · see citing works

Role of Bradykinin in Protection of Ischemic Preconditioning in Rabbit Hearts

Goto, M., Liu, Y., Yang, X., Ardell, J. L., Cohen, M. V., & Downey, J. M. (1995) · Circulation Research · doi:10.1161/01.res.77.3.611 · Cited by 529 · see citing works

Oxygen Radicals Released During Ischemic Preconditioning Contribute to Cardioprotection in the Rabbit Myocardium

Baines, C. P., Goto, M., & Downey, J. M. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0265 · Cited by 484 · see citing works

Diazoxide-Induced Cardioprotection Requires Signaling Through a Redox-Sensitive Mechanism

Forbes, R. A., Steenbergen, C., & Murphy, E. (2001) · Circulation Research · doi:10.1161/hh0801.089342 · Cited by 395 · see citing works

Morphine Mimics the Cardioprotective Effect of Ischemic Preconditioning via a Glibenclamide-Sensitive Mechanism in the Rat Heart

Schultz, J. E. J., Hsu, A. K., & Gross, G. J. (1996) · Circulation Research · doi:10.1161/01.res.78.6.1100 · Cited by 368 · see citing works

Ischemic Preconditioning Activates Phosphatidylinositol-3-Kinase Upstream of Protein Kinase C

Tong, H., Chen, W., Steenbergen, C., & Murphy, E. (2000) · Circulation Research · doi:10.1161/01.res.87.4.309 · Cited by 366 · see citing works

Ischemic preconditioning protects against infarction in rat heart

Liu, Y., & Downey, J. M. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.4.h1107 · Cited by 352 · see citing works

ATP‐sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria

Holmuhamedov, E., Wang, L., & Terzic, A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0347m.x · Cited by 346 · see citing works

Evidence for involvement of opioid receptors in ischemic preconditioning in rat hearts

Schultz, J. E. J., Rose, E., Yao, Z., & Gross, G. J. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.5.h2157 · Cited by 324 · see citing works

Preconditioning in Cardiomyocytes Protects by Attenuating Oxidant Stress at Reperfusion

Hoek, T. L. V., Becker, L. B., Shao, Z., Li, C., & Schumacker, P. T. (2000) · Circulation Research · doi:10.1161/01.res.86.5.541 · Cited by 312 · see citing works

Acetylcholine, Bradykinin, Opioids, and Phenylephrine, but not Adenosine, Trigger Preconditioning by Generating Free Radicals and Opening Mitochondrial K ATP Channels

Cohen, M. V., Yang, X., Liu, G. S., Heusch, G., & Downey, J. M. (2001) · Circulation Research · doi:10.1161/hh1501.094266 · Cited by 309 · see citing works

Oxygen Radicals Can Induce Preconditioning in Rabbit Hearts

Tritto, I., D’Andrea, D., Eramo, N., Scognamiglio, A., De Simone, C., Violante, A., Esposito, A., Chiariello, M., & Ambrosio, G. (1997) · Circulation Research · doi:10.1161/01.res.80.5.743 · Cited by 288 · see citing works

Role of bradykinin in myocardial preconditioning.

Wall, T. M., Sheehy, R. M., & Hartman, J. C. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22425-9 · Cited by 244 · see citing works

Mechanisms by which opening the mitochondrial ATP- sensitive K+channel protects the ischemic heart

Santos, P. D. D., Kowaltowski, A. J., Laclau, M. N., Seetharaman, S., Pauček, P., Boudina, S., Thambo, J., Tariosse, L., & Garlid, K. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00034.2002 · Cited by 221 · see citing works

Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation

Özcan, C., Bienengraeber, M., Dzeja, P. P., & Terzic, A. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00552.2001 · Cited by 195 · see citing works

Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits.

Miki, T., Cohen, M. V., & Downey, J. M. (1998) · PubMed · Cited by 158 · see citing works

Direct Preconditioning of Cardiac Myocytes via Opioid Receptors and KATPChannels

Liang, B. T., & Gross, G. J. (1999) · Circulation Research · doi:10.1161/01.res.84.12.1396 · Cited by 156 · see citing works

Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells

Krenz, M., Oldenburg, O., Wimpee, H., Cohen, M. V., Garlid, K., Critz, S. D., Downey, J. M., & Benoit, J. N. (2002) · Basic Research in Cardiology · doi:10.1007/s003950200045 · Cited by 145 · see citing works

ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases

Krieg, T., Qin, Q., McIntosh, E., Cohen, M. V., & Downey, J. M. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00474.2002 · Cited by 132 · see citing works

Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes

Yao, Z., Tong, J., Tan, X., Li, C., Shao, Z., Kim, W. C., Hoek, T. L. V., Becker, L. B., Head, C. A., & Schumacker, P. T. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.6.h2504 · Cited by 125 · see citing works

Acetylcholine mimics ischemic preconditioning via a glibenclamide-sensitive mechanism in dogs

Yao, Z., & Gross, G. J. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.264.6.h2221 · Cited by 118 · see citing works

Acetylcholine leads to free radical production dependent on KATP channels, Gi proteins, phosphatidylinositol 3-kinase and tyrosine kinase

Oldenburg, O. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00332-2 · Cited by 105 · see citing works

Morphine Mimics Preconditioning via Free Radical Signals and Mitochondrial KATPChannels in Myocytes

McPherson, B. C., & Yao, Z. (2001) · Circulation · doi:10.1161/01.cir.103.2.290 · Cited by 104 · see citing works

Dual roles of mitochondrial KATPchannels in diazoxide-mediated protection in isolated rabbit hearts

Wang, S., Cone, J. L., & Liu, Y. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.1.h246 · Cited by 97 · see citing works

Protection of Ischemic Preconditioning is Dependent upon a Critical Timing Sequence of Protein Kinase C Activation

Yang, X., Sato, H., Downey, J. M., & Cohen, M. V. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0344 · Cited by 86 · see citing works

Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase

Qin, Q., Downey, J. M., & Cohen, M. V. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00476.2002 · Cited by 74 · see citing works

Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial KATP channel opening

Oldenburg, O. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00083-x · Cited by 73 · see citing works

Signal Transduction of Opioid-induced Cardioprotection in Ischemia-Reperfusion

McPherson, B. C., & Yao, Z. (2001) · Anesthesiology · doi:10.1097/00000542-200106000-00024 · Cited by 53 · see citing works

Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals

Krieg, T., Landsberger, M., ALEXEYEV, M. F., Felix, S. B., COHEN, M., & Downey, J. M. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00861-1 · Cited by 43 · see citing works

Naloxone blockade of myocardial ischemic preconditioning does not require central nervous system participation

Chien, G. L., Mohtadi, K., Wolff, R., & Winkle, D. M. V. (1999) · Basic Research in Cardiology · doi:10.1007/s003950050136 · Cited by 40 · see citing works

Preischaemic bradykinin and ischaemic preconditioning in functional recovery of the globally ischaemic rat heart

Starkopf, J. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00195-2 · Cited by 34 · see citing works

Activation of ATP‐dependent potassium channels is a trigger but not a mediator of ischaemic preconditioning in pigs

Schulz, R., Gres, P., & Heusch, G. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705225 · Cited by 22 · see citing works

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · see citing works

Hypoxia Tolerance in Reptiles, Amphibians, and Fishes: Life with Variable Oxygen Availability

Bickler, P. E., & Buck, L. T. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.031905.162529 · Cited by 687 · see citing works

Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways

Yang, X., Proctor, J. B., Cui, L., Krieg, T., Downey, J. M., & Cohen, M. V. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.05.060 · Cited by 499 · see citing works

Evidence for Mitochondrial K + Channels and Their Role in Cardioprotection

O'Rourke, B. P. (2004) · Circulation Research · doi:10.1161/01.res.0000117583.66950.43 · Cited by 444 · see citing works

Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies

Soares, R. O. D. S., Losada, D. M., Jordani, M. C., Évora, P. R. B., & Castro-e-Silva, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205034 · Cited by 415 · see citing works

The role of mitochondria in protection of the heart by preconditioning

Halestrap, A. P., Clarke, S. J., & Khaliulin, I. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.05.008 · Cited by 390 · see citing works

Superoxide generation by complex III: From mechanistic rationales to functional consequences

Bleier, L., & Dröse, S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.12.002 · Cited by 369 · see citing works

Mitochondrial potassium transport: the role of the mitochondrial ATP-sensitive K+ channel in cardiac function and cardioprotection

Garlid, K., Santos, P. D. D., Xie, Z., Costa, A. D. T., & Pauček, P. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(03)00109-9 · Cited by 332 · see citing works

Mitochondrial Ion Channels

O'Rourke, B. P. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.031905.163804 · Cited by 311 · see citing works

Protein Kinase G Transmits the Cardioprotective Signal From Cytosol to Mitochondria

Costa, A. D. T., Garlid, K. D., West, I. C., Lincoln, T. M., Downey, J. M., Cohen, M. V., & Critz, S. D. (2005) · Circulation Research · doi:10.1161/01.res.0000178451.08719.5b · Cited by 307 · see citing works

Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection

Oldenburg, O., Qin, Q., Krieg, T., Yang, X., Philipp, S., Critz, S. D., Cohen, M. V., & Downey, J. M. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00360.2003 · Cited by 264 · see citing works

Biochemical dysfunction in heart mitochondria exposed to ischaemia and reperfusion

Solaini, G., & Harris, D. A. (2005) · Biochemical Journal · doi:10.1042/bj20042006 · Cited by 248 · see citing works

Impairment of Diazoxide-Induced Formation of Reactive Oxygen Species and Loss of Cardioprotection in Connexin 43 Deficient Mice

Heinzel, F. R., Luo, Y., Li, X., Boengler, K., Buechert, A., David Garcia-dorado, A., Lisa, F. D., Schulz, R., & Heusch, G. (2005) · Circulation Research · doi:10.1161/01.res.0000181171.65293.65 · Cited by 248 · see citing works

K channels and preconditioning: A re-examination of the role of mitochondrial K channels and an overview of alternative mechanisms

HANLEY, P., & DAUT, J. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.04.002 · Cited by 218 · see citing works

Mitochondrial K channels in cell survival and death

Ardehali, H., & O'Rourke, B. P. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.12.003 · Cited by 211 · see citing works

Differential effects of complex II on mitochondrial ROS production and their relation to cardioprotective pre- and postconditioning

Dröse, S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.01.004 · Cited by 201 · see citing works

Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics

DEZFULIAN, C., RAAT, N., SHIVA, S., & GLADWIN, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.001 · Cited by 198 · see citing works

Cardioprotective signaling to mitochondria

Garlid, K., Costa, A. D. T., Quinlan, C. L., Pierre, S. V., & Santos, P. D. D. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.11.019 · Cited by 192 · see citing works

Rapamycin confers preconditioning-like protection against ischemia–reperfusion injury in isolated mouse heart and cardiomyocytes

Khan, S. A., Salloum, F. N., Das, A., Xi, L., Vetrovec, G. W., & Kukreja, R. C. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.04.014 · Cited by 189 · see citing works

Generator-specific targets of mitochondrial reactive oxygen species

Bleier, L., Wittig, I., Heide, H., Steger, M., Brandt, U., & Dröse, S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.511 · Cited by 183 · see citing works

The Influence of Mitochondrial KATP-Channels in the Cardioprotection of Preconditioning and Postconditioning by Sevoflurane in the Rat In Vivo

Obal, D., Dettwiler, S., Favoccia, C., Scharbatke, H., Preckel, B., & Schlack, W. S. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000181336.96511.32 · Cited by 169 · see citing works

Mechanisms of Sudden Cardiac Death: Oxidants and Metabolism

Yang, K.-C., Kyle, J. W., Makielski, J. C., & Dudley, S. C. (2015) · Circulation Research · doi:10.1161/circresaha.116.304691 · Cited by 127 · see citing works

Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca²⁺-sensitive K⁺ channels

Heinen, A., Aldakkak, M., Stowe, D. F., Rhodes, S. S., Riess, M. L., Varadarajan, S. G., & Camara, A. K. S. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00198.2007 · Cited by 103 · see citing works

Adaptive responses of vertebrate neurons to anoxia—Matching supply to demand

Buck, L. T., & Pamenter, M. E. (2006) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2006.03.004 · Cited by 101 · see citing works

KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury

Soltysinska, E., Bentzen, B. H., Barthmes, M., Hattel, H. B., Thrush, A. B., Harper, M., Qvortrup, K., Larsen, F. J., Schiffer, T. A., Losa‐Reyna, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103402 · Cited by 97 · see citing works

Temperature preconditioning of isolated rat hearts – a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore

Халиулин, И. Г., Clarke, S. J., Lin, H., Parker, J. E., Suleiman, M. S., & Halestrap, A. P. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.130369 · Cited by 88 · see citing works

Myocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans

Xia, Z., Li, H., & Irwin, M. G. (2016) · British Journal of Anaesthesia · doi:10.1093/bja/aew267 · Cited by 83 · see citing works

Effects of nitrite on modulating ROS generation following ischemia and reperfusion

Raat, N. J. H., Shiva, S., & Gladwin, M. T. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.02.002 · Cited by 79 · see citing works

Mitochondria and GSK-3β in Cardioprotection Against Ischemia/Reperfusion Injury

Miura, T., & Tanno, M. (2010) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-010-6234-z · Cited by 79 · see citing works

Mapping Preconditioning's Signaling Pathways

Downey, J. M., Krieg, T., & Cohen, M. V. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1420.022 · Cited by 54 · see citing works

Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III

Dröse, S., Hanley, P. J., & Brandt, U. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.01.011 · Cited by 72 · see citing works

Mitochondria: a multimodal hub of hypoxia tolerance

Pamenter, M. E. (2014) · Canadian Journal of Zoology · doi:10.1139/cjz-2013-0247 · Cited by 69 · see citing works

Effects of Aging on Cardiac Oxidative Stress and Transcriptional Changes in Pathways of Reactive Oxygen Species Generation and Clearance

Rizvi, F., Preston, C. C., Emelyanova, L. V., Yousufuddin, M., Maria, V., Dakwar, O., Ross, G. R., Faustino, R. S., Holmuhamedov, E., & Jahangir, A. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019948 · Cited by 69 · see citing works

A common mechanism links differently acting complex II inhibitors to cardioprotection: modulation of mitochondrial reactive oxygen species production

Dröse, S., Bleier, L., & Brandt, U. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.070342 · Cited by 64 · see citing works

Mitochondrial Potassium ATP Channels and Retinal Ischemic Preconditioning

Roth, S., Dreixler, J. C., Shaikh, A. R., Lee, K. H., & Bindokas, V. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1068 · Cited by 60 · see citing works

Protection against ventricular arrhythmias and cardiac death using adenosine and lidocaine during regional ischemia in the in vivo rat

Canyon, S. J., & Dobson, G. P. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00273.2004 · Cited by 60 · see citing works

Oxytocin protects cardiomyocytes from apoptosis induced by ischemia–reperfusion in rat heart: Role of mitochondrial ATP-dependent potassium channel and permeability transition pore

Alizadeh, A. M., Faghihi, M., Khori, V., Sohanaki, H., Pourkhalili, K., Mohammadghasemi, F., & Mohsenikia, M. (2012) · Peptides · doi:10.1016/j.peptides.2012.03.023 · Cited by 58 · see citing works

Determination of the rate of K+ movement through potassium channels in isolated rat heart and liver mitochondria

Bednarczyk, P., Barker, G. D., & Halestrap, A. P. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.04.018 · Cited by 54 · see citing works

Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS

Philipp, S., Cui, L., Ludolph, B., Kelm, M., Schulz, R., Cohen, M. V., & Downey, J. M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00472.2005 · Cited by 54 · see citing works

Mitochondrial Dysfunction Confers Resistance to Multiple Drugs inCaenorhabditis elegans

Zubovych, I. O., Straud, S., & Roth, M. G. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-08-0673 · Cited by 52 · see citing works

Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes

Iwase, H., Robin, E., Guzy, R. D., Mungai, P. T., Hoek, T. L. V., Chandel, N. S., Levraut, J., & Schumacker, P. T. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.017 · Cited by 51 · see citing works

Oxytocin protects rat heart against ischemia–reperfusion injury via pathway involving mitochondrial ATP-dependent potassium channel

Alizadeh, A. M., Faghihi, M., Sadeghipour, H. R., Mohammadghasemi, F., Imani, A., Houshmand, F., & Khori, V. (2010) · Peptides · doi:10.1016/j.peptides.2010.04.012 · Cited by 49 · see citing works

Preconditioning Approach in Stem Cell Therapy for the Treatment of Infarcted Heart

Haider, K. H., & Ashraf, M. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-398459-3.00015-0 · Cited by 46 · see citing works

Cell isolation and culture

Zhang, S. (2013) · WormBook · doi:10.1895/wormbook.1.157.1 · Cited by 45 · see citing works

Role of KATP channels in protection against neuronal excitatory insults

Soundarapandian, M. M., Zhong, X., Peng, L., Wu, D., & Lu, Y. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04963.x · Cited by 45 · see citing works

β1-Adrenoreceptor activation contributes to ischemia-reperfusion damage as well as playing a role in ischemic preconditioning

Spear, J. F., Prabu, S. K., Galati, D. F., Raza, H., Anandatheerthavarada, H. K., & Avadhani, N. G. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00459.2006 · Cited by 45 · see citing works

Pre? and postconditioning during cardiac surgery

Valen, G., & Vaage, J. (2005) · Basic Research in Cardiology · doi:10.1007/s00395-005-0517-8 · Cited by 42 · see citing works

K+-dependent regulation of matrix volume improves mitochondrial function under conditions mimicking ischemia-reperfusion

Kôrge, P., Honda, H. M., & Weiss, J. N. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01296.2004 · Cited by 36 · see citing works

First Aid Kit for Hypoxic Survival: Sensors and Strategies

López‐Barneo, J., Nurse, C. A., Nilsson, G., Buck, L. T., Gassmann, M., & Bogdanova, A. Y. (2010) · Physiological and Biochemical Zoology · doi:10.1086/651584 · Cited by 34 · see citing works

Systemic administration of diazoxide induces delayed preconditioning against transient focal cerebral ischemia in rats

Mayanagi, K., Gáspár, T., Katakam, P. V. G., & Busija, D. W. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.071 · Cited by 34 · see citing works

The role of mitochondrial KATP channels in antiarrhythmic effects of ischaemic preconditioning in dogs

Végh, Á., & Parratt, J. R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704966 · Cited by 33 · see citing works

Nicorandil opens mitochondrial KATP channels not only directly but also through a NO-PKG-dependent pathway

Kuno, A., Critz, S. D., Cohen, M. V., & Downey, J. M. (2006) · Basic Research in Cardiology · doi:10.1007/s00395-006-0612-5 · Cited by 31 · see citing works

Adenosine relaxation in isolated rat aortic rings and possible roles of smooth muscle Kv channels, KATP channels and A2a receptors

Arsyad, A., & Dobson, G. P. (2016) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-016-0067-8 · Cited by 31 · see citing works

Interruption of signal transduction between G protein and PKC-ε underlies the impaired myocardial response to ischemic preconditioning in postinfarct remodeled hearts

Miki, T., Miura, T., Tanno, M., Sakamoto, J., Kuno, A., Genda, S., Matsumoto, T., Ichikawa, Y., & Shimamoto, K. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024124016053 · Cited by 31 · see citing works

Myocardial protection in man—from research concept to clinical practice

Cokkinos, D. V., & Pantos, C. (2007) · Heart Failure Reviews · doi:10.1007/s10741-007-9030-5 · Cited by 28 · see citing works

Pretreatment with an adenosine A1 receptor agonist and lidocaine: A possible alternative to myocardial ischemic preconditioning

Canyon, S. J., & Dobson, G. P. (2005) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2004.12.052 · Cited by 28 · see citing works

Vagal nerve modulation: A promising new therapeutic approach for cardiovascular diseases

Zhao, M., Sun, L., Liu, J., Wang, H., Miao, Y., & Zang, W. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05644.x · Cited by 26 · see citing works

Rapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion.

Ghasemnejad‐Berenji, M., Ghazi‐Khansari, M., Yazdani, I., Saravi, S. S. S., Nobakht, M., Abdollahi, A., Ansari, J. M., Ghasemnejad-Berenji, H., Pashapour, S., & Dehpour, A. R. (2017) · PubMed Central · doi:10.22038/ijbms.2017.9112 · Cited by 26 · see citing works

Hypoxic–hyperoxic conditioning and dementia

Mallet, R. T., Burtscher, J., Manukhina, E. B., Downey, H. F., Glazachev, O. S., Serebrovskaya, T. V., & Burtscher, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815854-8.00047-1 · Cited by 23 · see citing works

cGMP and mitochondrial K+ channels—Compartmentalized but closely connected in cardioprotection

Łukowski, R., Santos, M. C., Kuret, A., & Ruth, P. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15536 · Cited by 22 · see citing works

Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt

Cao, Z., Liu, L., Packwood, W. H., Merkel, M. J., Hurn, P. D., & Winkle, D. M. V. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00845.2007 · Cited by 22 · see citing works

Targets of cGMP/cGKI in Cardiac Myocytes

Adler, J., Kuret, A., Längst, N., & Łukowski, R. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000817 · Cited by 21 · see citing works

Effect of Pressure Overload on Cardioprotection via PI3K-Akt: Comparison of Postconditioning, Insulin, and Pressure Unloading

Mozaffari, M. S., Liu, J. Y., & Schaffer, S. W. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.43 · Cited by 20 · see citing works

Role of endogenous nitric oxide in classic preconditioning in rat hearts

Prendes, M. G. M., González, M. J., Savino, E. A., & Varela, A. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.10.015 · Cited by 19 · see citing works

Pharmacological Preconditioning With Bradykinin Affords Myocardial Protection Through NO-dependent Mechanisms

Yoshida, H., Kusama, Y., Kodani, E., Yasutake, M., Takano, H., Atarashi, H., Kishida, H., & Takano, T. (2005) · International Heart Journal · doi:10.1536/ihj.46.877 · Cited by 18 · see citing works

Coronary Artery Disease: Pathologic Anatomy and Pathogenesis

Buja, L. M., & McAllister, H. A. (2007) · Springer eBooks · doi:10.1007/978-1-84628-715-2_25 · Cited by 17 · see citing works

Neuronal preconditioning with the antianginal drug, bepridil

Gáspár, T., Kis, B., Snipes, J. A., Lenzsér, G., Mayanagi, K., Bari, F., & Busija, D. W. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04501.x · Cited by 15 · see citing works

Protective and anti-protective effects of acute ethanol exposure in myocardial ischemia/reperfusion

Krenz, M., Cohen, M. V., & Downey, J. M. (2003) · Pathophysiology · doi:10.1016/j.pathophys.2003.10.006 · Cited by 13 · see citing works

Lidocaine relaxation in isolated rat aortic rings is enhanced by endothelial removal: possible role of Kv, KATP channels and A2a receptor crosstalk

Arsyad, A., & Dobson, G. P. (2016) · BMC Anesthesiology · doi:10.1186/s12871-016-0286-y · Cited by 12 · see citing works

Effects of Abeta1–42 on the current of KATP channels in cultured cholinergic neurons

Tan, S., Ma, G., Li, Y., Li, J., Yao, W., Ren, X., Liu, X., & Gao, J. (2012) · Neurological Research · doi:10.1179/1743132812y.0000000069 · Cited by 11 · see citing works

Free radicals in the heart: friend or foe?

Downey, J. M., & Cohen, M. V. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.5.589 · Cited by 11 · see citing works

Mitochondrial Ion Channels

O'Rourke, B. P. (2007) · Springer eBooks · doi:10.1007/978-0-387-69945-5_10 · Cited by 9 · see citing works

ATP-Sensitive Potassium Channel Modulators and Cardiac Arrhythmias: An Update

Muntean, D. M., Kiss, L., Jost, N., & Baczkó, I. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666141029102800 · Cited by 6 · see citing works

Comment utiliser le paradigme de préconditionnement ischémique pour protéger le myocarde

Argaud, L., & Ovize, M. (2004) · Érudit (Université de Montréal) · doi:10.7202/008417ar · Cited by 6 · see citing works

Optimizing Nicorandil for Spinal Cord Protection in a Murine Model of Complex Aortic Intervention

Ikeno, Y., Ghincea, C. V., Roda, G. F., Cheng, L., Aftab, M., Meng, X., Weyant, M. J., Cleveland, J. C., Fullerton, D. A., & Reece, T. B. (2021) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2021.01.003 · Cited by 5 · see citing works

Myocardial protection: a new Holy Grail of contemporary cardiology.

Cokkinos, D. V., & Pantos, C. (2005) · PubMed · Cited by 4 · see citing works

The Mitochondrial Permeability Transition Pore – from Molecular Mechanism to Reperfusion Injury and Cardioprotection

Halestrap, A. P., Clarke, S. J., & Khalilin, I. (2007) · Springer eBooks · doi:10.1007/978-0-387-69945-5_11 · Cited by 3 · see citing works

6.5 Mitochondrial Mechanisms of Oxidative Stress and Apoptosis

Soane, L., Solenski, N. J., & Fiskum, G. M. (2007) · Springer eBooks · doi:10.1007/978-0-387-30411-3_26 · Cited by 1 · see citing works

Focused issue on KATP channels K ATP channels and preconditioning: A re-examination of the role of mitochondrial K ATP channels and an overview of alternative mechanisms

Hanley, P. J., & Daut, J. (2005) · Cited by 1 · see citing works

Myocardial Protection — From Concepts to Clinical Practice

Cokkinos, D. V. (2006) · Springer eBooks · doi:10.1007/0-387-28658-6_8

The role of mitochondria in cardioprotection

Heinen, A. (2008) · UvA-DARE (University of Amsterdam)

Elucidating the mechanism of cardiac ischemia and reperfusion by proteomics approach

Xin, L. (2011) · doi:10.32657/10356/48669

Nitrite is a vascular store of NO which mediates hypoxic signaling and protects against ischemia/reperfusion injury

(2007) · Advances in experimental biology · doi:10.1016/s1872-2423(07)01010-1

Ions and channels: new answers to old questions

COHEN, M. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.06.002

From the organizers

Porter, R. K. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.05.440

Reducing infarct size by ischemic preconditioning versus insulin treatment in the heart : same outcome - similar mechanisms?

Fuglesteg, B. N. (2008) · NORA - Norwegian Open Research Archives

Participação da mitocôndria na regulação da viabilidade celular.

Kowaltowski, A. J. (2007) · Universidade de São Paulo · doi:10.11606/t.46.2007.tde-08102007-145540

EPICARDIAL AUTO-FLUORESCENCE NAD(P)H KINETICS IN THE ISCHEMICALLY PRECONDITIONED LANGERDORFF RAT HEART. EFFECTS OF CAPSAICIN. PART 2.

Rossini, L., Kuzio, B., Deslauriers, R., & Johnson, C. W. (2005)

Adenosinergic and GABAergic Modulation of Neuronal Activity in the Hypoxia-tolerant Pond Snail Lymnaea Stagnalis

Malik, A. (2011) · TSpace (University of Toronto)

Glutamate excitotoxicity in epilepsy and ischemia

Soundarapandian, M. M. (2007) · Journal of International Crisis and Risk Communication Research

Mecanismos de acción de intervenciones cardioprotectoras durante la isquemia y la reperfusión en ratas normales e hipertróficas

Fantinelli, J. C. (2009) · doi:10.35537/10915/4354

Pharmacologic ROMK Inhibition Protects Against Myocardial Ischemia Reperfusion Injury

Wexler, A. C., Dooge, H. C., Serban, L., Tewari, A., Tehrani, B., Alvarado, F. J., & Ramratnam, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083795

Mise en évidence des récepteurs mitochondriaux de type sigma 1 et rôle dans la prévention des lésions cellulaires de l'ischémie-reperfusion

Klouz, A. (2007)

Ischemic Preconditioning Protects Adult Rat Cardiomyocytes Against Necrosis but not Apoptosis, via Activation of PKG

Caligtan, M. J. (2005) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/zkrb-3r66

Myocardial preconditioning: Basic concepts and potential mechanisms

Okubo, S., Xi, L., Bernardo, N. L., Yoshida, K.-I., & Kukreja, R. C. (1999) · Springer eBooks · doi:10.1007/978-1-4615-5097-6_1 · Cited by 55 · see citing works

Mitochondrial KATP channels are possible triggers of ischemic preconditioning protective effect against reperfusion arrhythmias

Muntean, D. M., Cristescu, A., Firă-Mladinescu, O., Mihaicuta, D., & Lighezan, D. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(02)90902-8

Focused issue on KATP channels K ATP channels and preconditioning: A re-examination of the role of mitochondrial K ATP channels and an overview of alternative mechanisms

Hanley, P. J., & Daut, J. (2005) · Cited by 1 · see citing works

Evidence for mitochondrial KATP channels as effectors of human myocardial preconditioning

Ghosh, S. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00407-1 · Cited by 122 · see citing works

Myocardial KATP Channels in Preconditioning

BrianO’Rourke (2000) · Circulation Research · Cited by 18 · see citing works