The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Deformation-induced ATP release from red blood cells requires CFTR activity
Abstract
Recently, it was reported that rabbit and human red blood cells (RBCs) release ATP in response to mechanical deformation. Here we investigate the hypothesis that the activity of the cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ATP binding cassette, is required for deformation-induced ATP release from RBCs. Incubation of rabbit RBCs with either of two inhibitors of CFTR activity, glibenclamide (10 μM) or niflumic acid (20 μM), resulted in inhibition of deformation-induced ATP release. To demonstrate the contribution of CFTR to deformation-induced ATP release from human RBCs, cells from healthy humans, patients with cystic fibrosis (CF), or patients with chronic obstructive lung disease (COPD) unrelated to CF were studied. RBCs of healthy humans and COPD patients released ATP in response to mechanical deformation. In contrast, deformation of RBCs from patients with CF did not result in ATP release. We conclude that deformation-induced ATP release from rabbit and human RBCs requires CFTR activity, suggesting a previously unrecognized role for CFTR in the regulation of vascular resistance.
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Cites
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The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.
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Self-citationMembrane topology distinguishes a subfamily of the ATP‐binding cassette (ABC) transporters
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Failure of the Cystic Fibrosis Transmembrane Conductance Regulator to Conduct ATP
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Self-citation
Metadata
- Authors
- Sprague, R. S., Ellsworth, M. L., Stephenson, A. H., Kleinhenz, M. E., & Lonigro, A. J.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1998-11-01
- Volume
- 275
- Issue
- 5
- Pages
- H1726-H1732
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2181400332
- Cited by
- 287
- References
- 21
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sprague, R. S., Ellsworth, M. L., Stephenson, A. H., Kleinhenz, M. E., & Lonigro, A. J. (1998). Deformation-induced ATP release from red blood cells requires CFTR activity. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.1998.275.5.h1726
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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