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Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow
Abstract
Recombinant human interleukin-6 (IL-6) causes both a thrombocytosis and leukocytosis. The thrombocytosis is caused by an accelerating thrombocytopoiesis, but the mechanism of the leukocytosis is unknown. This study was designed to determine the relative contributions of marrow stimulation and intravascular demargination to the IL-6 induced neutrophilia. IL-6 (2 μg/kg), administered intravenously to rabbits, caused a biphasic neutrophilia with an initial peak at 3 h and a second peak at 9 h. Using the thymidine analog 5′-bromo-2′-deoxyuridine (BrdU) to label dividing polymorphonuclear leukocytes (PMNs) in the bone marrow, we showed that IL-6 treatment mobilizes PMNs from the marginated pool into the circulating pool at 2–6 h with a decrease inl-selectin expression on PMNs and also accelerates the release of PMNs from the postmitotic pool in the bone marrow at 12–24 h. We have concluded that IL-6 causes a biphasic neutrophilia wherein the first peak results from the mobilization of PMNs into the circulating pool from the marginated pool and the second peak results from an accelerated bone marrow release of PMNs.
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“It is thought that neutropenia is not due to the myelotoxic effects of tocilizumab but rather to changes in the localization of circulating neutrophils”
From Targeting Interleukin-6 Signaling in Clinic (2019) · cites this paper as Suwa et al., 2000
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Cited by
Sorted by citations
Targeting Interleukin-6 Signaling in Clinic
Kang, S., Tanaka, T., Narazaki, M., & Kishimoto, T. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.026 · Cited by 904
Wedell-Neergaard, A.-S., Lang Lehrskov, L., Christensen, R. H., Legaard, G. E., Dorph, E., Larsen, M. K., Launbo, N., Fagerlind, S. R., Seide, S. K., Nymand, S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.007 · Cited by 403
The hematologic consequences of obesity
Purdy, J. C., & Shatzel, J. J. (2021) · European Journal Of Haematology · doi:10.1111/ejh.13560 · Cited by 227
Metadata
- Authors
- Suwa, T., Hogg, J. C., English, D., & Van Eeden, S. F.
- Affiliations
- Pulmonary Research Laboratory, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada V6Z 1Y6
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2000-12-01
- Volume
- 279
- Issue
- 6
- Pages
- H2954-H2960
- ISSN
- 0363-6135
- 1522-1539
- Cited by
- 141
- References
- 0
- Language
- en
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- Suwa, T., Hogg, J. C., English, D., & Van Eeden, S. F. (2000). Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.2000.279.6.h2954
