The hematologic consequences of obesity

Purdy, Johanna C.; Shatzel, Joseph J.

doi:10.1111/ejh.13560

Cited by 227Adipokines, Inflammation, and Metabolic DiseasesInflammatory Biomarkers in Disease PrognosisCancer Risks and Factors

The hematologic consequences of obesity

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Purdy, Johanna C., Shatzel, Joseph J.·2021·European Journal Of Haematology

DOI 10.1111/ejh.13560PMC PMC8086364

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Abstract

The prevalence of obesity is increasing and progressively influencing physician-patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low-grade inflammation, to our knowledge, there is no single review summarizing its effects on hematologic parameters and thrombotic risk. We performed a literature search which largely surfaced observational studies, with a few systematic reviews and meta-analyses of these studies. We took care to review the mechanisms driving an inflammatory state and obesity's effect on white blood cells, red blood cells, platelets, and thrombotic risk. There is an observed relative, and sometimes absolute leukocytosis driven by this inflammatory state. Obesity is also associated with increased platelet counts and an increased risk for venous thromboembolism (VTE). Lastly, the association between obesity, iron deficiency (ID), and red blood cell counts may be present but remains uncertain. Recognizing the above associations may provide clinicians with reassurance regarding otherwise unexplained hematologic abnormalities in obese individuals. We hope this review will prompt future studies to further understand the underlying mechanisms driving these abnormalities and identify modifiable risk factors and potential therapeutic targets to prevent the development of probable obesity-associated conditions with significant morbidity and mortality, such as ID and VTE.

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Increased body mass index and obesity are associated with leukocytosis across multiple studies.
“Increased body mass index and obesity are associated with leukocytosis across multiple studies, 22”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [22]
Increased platelet activity and thrombocytosis have been associated with obesity, particularly in women.
“Although increased platelet activity and thrombocytosis have been associated with obesity, particularly in women, 2,22”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [22]

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Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596 · see citing works
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595 · see citing works
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061 · see citing works
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · see citing works
Adipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606 · see citing works
Elevated C-reactive protein levels in overweight and obese adults
Visser, M. (1999) · JAMA · doi:10.1001/jama.282.22.2131 · Cited by 2,494 · see citing works
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465 · see citing works
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,012 · see citing works
Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity
Ward, Z. J., Bleich, S. N., Cradock, A. L., Barrett, J. L., Giles, C. M., Flax, C., Long, M. W., & Gortmaker, S. L. (2019) · New England Journal of Medicine · doi:10.1056/nejmsa1909301 · Cited by 2,009 · see citing works
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775 · see citing works
Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans
Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P. S., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,571 · see citing works
The cellular and signaling networks linking the immune system and metabolism in disease
Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551 · see citing works
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid 1
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,528 · see citing works
Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women: A Randomized Trial
Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., & Giugliano, D. (2003) · JAMA · doi:10.1001/jama.289.14.1799 · Cited by 1,511 · see citing works
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417 · see citing works
Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow
Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., & Morrison, S. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.008 · Cited by 1,381 · see citing works
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305 · see citing works
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid
Fried, S. K. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.847 · Cited by 1,146 · see citing works
Neutrophils: Molecules, Functions and Pathophysiological Aspects
Witko‐Sarsat, V., Rieu, P., Descamps‐Latscha, B., Lesavre, P., & Halbwachs‐Mecarelli, L. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780067 · Cited by 1,132 · see citing works
Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss
Bastard, J., Jardel, C., Bruckert, É., Blondy, P., Capeau, J., Laville, M., Vidal, H., & Hainque, B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6839 · Cited by 1,102 · see citing works
Cardiovascular Risk Factors and Venous Thromboembolism
Ageno, W., Becattini, C., Brighton, T., Selby, R., & Kamphuisen, P. W. (2007) · Circulation · doi:10.1161/circulationaha.107.709204 · Cited by 1,000 · see citing works
Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions in Obese Women After Weight Loss Over One Year
Ziccardi, P., Nappo, F., Giugliano, G., Esposito, K., Marfella, R., Cioffi, M., D’Andrea, F., Molinari, A. M., & Giugliano, D. (2002) · Circulation · doi:10.1161/hc0702.104279 · Cited by 994 · see citing works
Interleukin-6 induces hepcidin expression through STAT3
Wrighting, D. M., & Andrews, N. C. (2006) · Blood · doi:10.1182/blood-2006-06-027631 · Cited by 983 · see citing works
Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6
Park, H. S., Park, J. Y., & Yu, R. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.11.007 · Cited by 964 · see citing works
Oxidative stress in obesity: A critical component in human diseases
Marseglia, L., Manti, S., D’Angelo, G., Nicotera, A., Parisi, E., Di Rosa, G., Gitto, E., & Arrigo, T. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms16010378 · Cited by 933 · see citing works
Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress
Pou, K. M., Massaro, J. M., Hoffmann, U., Vasan, R. S., Maurovich‐Horvat, P., Larson, M. G., Keaney, J. F., Meigs, J. B., Lipinska, I., Kathiresan, S., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.710509 · Cited by 898 · see citing works
Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty
Shimomura, I., Funahasm, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., Yamashita, S., Miura, M., Fukuda, Y., Takemura, K., et al. (1996) · Nature Medicine · doi:10.1038/nm0796-800 · Cited by 890 · see citing works
Iron Deficiency in Infancy and Childhood
Desforges, J. F., & Oski, F. A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199307153290308 · Cited by 798 · see citing works
Mechanistic Pathways of Sex Differences in Cardiovascular Disease
Regitz‐Zagrosek, V., & Kararigas, G. (2016) · Physiological Reviews · doi:10.1152/physrev.00021.2015 · Cited by 738 · see citing works
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor- , in Vivo
Mohamed-Ali, V. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.12.4196 · Cited by 717 · see citing works
The relation of body fat mass and distribution to markers of chronic inflammation
Festa, A., D'Agostino, R., Jr., Williams, K. M., Aj, K., Mayer-Davis, E., Tracy, R. P., & Haffner, S. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801792 · Cited by 706 · see citing works
Cardiovascular Risk Factors and Venous Thromboembolism Incidence
Tsai, A. W., Cushman, M., Rosamond, W. D., Heckbert, S. R., Polak, J. F., & Folsom, A. R. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.10.1182 · Cited by 699 · see citing works
An Epidemiologic Study of Risk Factors for Deep Vein Thrombosis in Medical Outpatients
Samama, M.-M. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.22.3415 · Cited by 697 · see citing works
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis
Kaser, A., Brandacher, G., Steurer, W., Kaser, S., Offner, F. A., Zoller, H., Theurl, I., Widder, W., Molnar, C., Ludwiczek, O., et al. (2001) · Blood · doi:10.1182/blood.v98.9.2720 · Cited by 667 · see citing works
HYPOFERRÆMIA IN OBESE ADOLESCENTS
WENZEL, B. J., Stults, H., & Mayer, J. (1962) · The Lancet · doi:10.1016/s0140-6736(62)90110-1 · Cited by 652 · see citing works
Body mass index, diabetes, and C-reactive protein among U.S. adults.
Ford, E. S. (1999) · Diabetes Care · doi:10.2337/diacare.22.12.1971 · Cited by 645 · see citing works
The Role of Hepcidin in Iron Metabolism
Nemeth, E., & Ganz, T. (2009) · Acta Haematologica · doi:10.1159/000243791 · Cited by 607 · see citing works
Neutrophils as protagonists and targets in chronic inflammation
Soehnlein, O., Steffens, S., Hidalgo, A., & Weber, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.10 · Cited by 606 · see citing works
From Blood Monocytes to Adipose Tissue-Resident Macrophages
Curat, C. A., Miranville, A., Sengenès, C., Diehl, M., Tonus, C., Busse, R., & Bouloumié, A. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1285 · Cited by 600 · see citing works
Obesity as a risk factor in venous thromboembolism
Stein, P. D., Beemath, A., & Olson, R. E. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.03.012 · Cited by 588 · see citing works
Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy
Rodger, M. A., Kahn, S. R., Wells, P. S., Anderson, D. A., Chagnon, I., Le Gal, G., Solymoss, S., Crowther, M., Perrier, A., White, R., et al. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.080493 · Cited by 581 · see citing works
Macrophage Infiltration into Omental <i>Versus</i> Subcutaneous Fat across Different Populations: Effect of Regional Adiposity and the Comorbidities of Obesity
Harman-Boehm, I., Blüher, M., Redel, H., Sion-Vardy, N., Ovadia, S., Avinoach, E., Shai, I., Klöting, N., Stumvoll, M., Bashan, N., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1811 · Cited by 574 · see citing works
Platelet Activation in Obese Women
Davı̀, G., Guagnano, M. T., Ciabattoni, G., Basili, S., Falco, A., Marinopiccoli, M., Nutini, M., Sensi, S., & Patrono, C. (2002) · JAMA · doi:10.1001/jama.288.16.2008 · Cited by 542 · see citing works
Weight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women
Tchernof, A., Nolan, A., Sites, C. K., Ades, P. A., & Poehlman, E. T. (2002) · Circulation · doi:10.1161/hc0502.103331 · Cited by 541 · see citing works
Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH
Bekri, S., Gual, P., Anty, R., Luciani, N., Dahman, M., Ramesh, B., Iannelli, A., Staccini–Myx, A., Casanova, D., Ben Amor, I., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.007 · Cited by 496 · see citing works
Serum Inflammatory Markers in Obstructive Sleep Apnea: A Meta-Analysis
Nadeem, R. N., Molnár, J., Madbouly, E. M., Nida, M., Aggarwal, S., Hassan, S., Naseem, J., & Loomba, R. S. (2013) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.3070 · Cited by 486 · see citing works
The Chronic Inflammatory Hypothesis for the Morbidity Associated with Morbid Obesity: Implications and Effects of Weight Loss
Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R. (2004) · Obesity Surgery · doi:10.1381/096089204323093345 · Cited by 461 · see citing works
Obesity: risk of venous thrombosis and the interaction with coagulation factor levels and oral contraceptive use
Abdollahi, M., Cushman, M., & Rosendaal, F. R. (2003) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613379 · Cited by 444 · see citing works
Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial
Nicklas, B. J., Ambrosius, W., Messier, S. P., Miller, G. D., Penninx, B. W., Loeser, R. F., Palla, S., Bleecker, E., & Pahor, M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.544 · Cited by 443 · see citing works
Adipose tissue macrophages: going off track during obesity
Boutens, L., & Stienstra, R. (2016) · Diabetologia · doi:10.1007/s00125-016-3904-9 · Cited by 430 · see citing works
Iron deficiency in infancy and childhood
Dallman, P. R., Siimes, M. A., & Stekel, A. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.1.86 · Cited by 421 · see citing works
Risk Factors for Venous Thromboembolism
Holst, A. G., Jensen, G. B., & Prescott, E. (2010) · Circulation · doi:10.1161/circulationaha.109.921460 · Cited by 397 · see citing works
Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity
Konstantinides, S., Schäfer, K., Koschnick, S., & Loskutoff, D. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13143 · Cited by 373 · see citing works
Obesity, haemostasis and the fibrinolytic system
Mertens, I. L., & Gaal, L. F. V. (2002) · Obesity Reviews · doi:10.1046/j.1467-789x.2002.00056.x · Cited by 368 · see citing works
Overweight, Obesity, and the Risk of Recurrent Venous Thromboembolism
Eichinger, S. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1678 · Cited by 361 · see citing works
Raised Interleukin‐6 Levels in Obese Patients
Roytblat, L., Rachinsky, M., Fisher, A., Greemberg, L., Shapira, Y., Douvdevani, A., & Gelman, S. (2000) · Obesity Research · doi:10.1038/oby.2000.86 · Cited by 346 · see citing works
Obesity as an emerging risk factor for iron deficiency
Aigner, E., Feldman, A., & Datz, C. (2014) · Nutrients · doi:10.3390/nu6093587 · Cited by 328 · see citing works
A role for preadipocytes as macrophage‐like cells
Cousin, B., Muñoz, O., André, M., Fontanilles, A. M., Dani, C., Cousin, J. L., Laharrague, P. F., Casteilla, L., & Pénicaud, L. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.2.305 · Cited by 320 · see citing works
Release of C-Reactive Protein in Response to Inflammatory Cytokines by Human Adipocytes: Linking Obesity to Vascular Inflammation
Calabrò, P., Chang, D. W.-W., Willerson, J. T., & Yeh, E. T. H. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.06.017 · Cited by 309 · see citing works
Smoking and Abdominal Obesity
Hansson, P., Eriksson, H., Welin, L., Svärdsudd, K., & Wilhelmsen, L. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.16.1886 · Cited by 307 · see citing works
Serum Levels of Tumor Necrosis Factor-α Are Increased in Obese Patients with Noninsulin-Dependent Diabetes Mellitus1
Katsuki, A., Sumida, Y., Murashima, S., Murata, K., Takarada, Y., Ito, K., Fujii, M., Tsuchihashi, K., Goto, H., Nakatani, K., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4618 · Cited by 301 · see citing works
The mean platelet volume in patients with obesity
Çoban, E., Özdoğan, M., Yazicioglu, G., & Akcit, F. (2005) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2005.00500.x · Cited by 291 · see citing works
Obesity and iron deficiency: A quantitative meta-analysis
Zhao, L., Zhang, X., Shen, Y., Fang, X., Wang, Y., & Wang, F. (2015) · Obesity Reviews · doi:10.1111/obr.12323 · Cited by 286 · see citing works
Increased Thrombosis After Arterial Injury in Human C-Reactive Protein–Transgenic Mice
Danenberg, H. D., Szalai, A. J., Swaminathan, R. V., Peng, L., Chen, Z., Seifert, P. A., Fay, W. P., Simon, D. I., & Edelman, E. R. (2003) · Circulation · doi:10.1161/01.cir.0000085568.13915.1e · Cited by 283 · see citing works
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue
Nishimura, S., Manabe, I., Nagasaki, M., Seo, K., Yamashita, H., Hosoya, Y., Ohsugi, M., Tobe, K., Kadowaki, T., Nagai, R., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33328 · Cited by 277 · see citing works
Leptin promotes aggregation of human platelets via the long form of its receptor.
Nakata, M., Yada, T., Soejima, N., & Maruyama, I. (1999) · Diabetes · doi:10.2337/diabetes.48.2.426 · Cited by 244 · see citing works
Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification
Zimmermann, M. B., Zeder, C., Muthayya, S., Winichagoon, P., Chaouki, N., Aeberli, I., & Hurrell, R. F. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.43 · Cited by 225 · see citing works
Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults.
Folsom, A. R., Qamhieh, H. T., Wing, R. R., Jeffery, R. W., Stinson, V., Kuller, L. H., & Wu, K. K. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.2.162 · Cited by 224 · see citing works
Sharply higher rates of iron deficiency in obese Mexican women and children are predicted by obesity-related inflammation rather than by differences in dietary iron intake
Cepeda-Lopez, A. C., Osendarp, S. J. M., Melse‐Boonstra, A., Herter‐Aeberli, I., González‐Salazar, F., Feskens, E. J. M., Villalpando, S., & Zimmermann, M. B. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005439 · Cited by 222 · see citing works
New insights into the role of adipose tissue in thrombosis
Vilahur, G., Ben-Aicha, S., & Badimon, L. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx086 · Cited by 216 · see citing works
Aging and Thrombosis
Wilkerson, W. R., & Sane, D. C. (2002) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2002-36700 · Cited by 210 · see citing works
Adipokines oversecreted by omental adipose tissue in human obesity
Maury, E., Ehala-Aleksejev, K., Guiot, Y., Détry, R., Vandenhooft, A., & Brichard, S. M. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00127.2007 · Cited by 207 · see citing works
Association between obesity and a prothrombotic state: the Framingham Offspring Study
Rosito, G. A., D’Agostino, R. B., Massaro, J. M., Lipinska, I., Mittleman, M. A., Sutherland, P. A., Wilson, P. W. F., Levy, D. A., Muller, J. E., & Tofler, G. H. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-01-0014 · Cited by 206 · see citing works
Effects of Changes in Body Weight and Insulin Resistance on Inflammation and Endothelial Function in Morbid Obesity after Bariatric Surgery
Vázquez, L. A., Pazos, F., de Berrazueta, J. R., Fernández-Escalante, C., García‐Unzueta, M. T., Freijanes, J., & Amado, J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032059 · Cited by 205 · see citing works
In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs
Ulich, T., del Castillo, J. M. G., & Guo, K. (1989) · Blood · doi:10.1182/blood.v73.1.108.108 · Cited by 204 · see citing works
Hepcidin in Obese Children as a Potential Mediator of the Association between Obesity and Iron Deficiency
del Giudice, E. M., Santoro, N., Amato, A., Brienza, C., Calabrò, P., Wiegerinck, E. T. G., Cirillo, G., Tartaglione, N., Grandone, A., Swinkels, D. W., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1361 · Cited by 198 · see citing works
Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children
Herter‐Aeberli, I., Hurrell, R. F., & Zimmermann, M. B. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.146 · Cited by 191 · see citing works
Tissue Distribution and Regulation of Plasminogen Activator Inhibitor-1 in Obese Mice
Samad, F., & Loskutoff, D. J. (1996) · Molecular Medicine · doi:10.1007/bf03401641 · Cited by 189 · see citing works
Leptin Increases the Expression of the Iron Regulatory Hormone Hepcidin in HuH7 Human Hepatoma Cells
Chung, B., Matak, P., McKie, A. T., & Sharp, P. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2366 · Cited by 186 · see citing works
Obesity and venous thrombosis: a review
Allman-Farinelli, M. (2011) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0031-1297369 · Cited by 183 · see citing works
Tumor Necrosis Factor- in Sera of Obese Patients: Fall with Weight Loss
Dandona, P. (1998) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.8.2907 · Cited by 176 · see citing works
Leukocytosis in obese individuals: possible link in patients with unexplained persistent neutrophilia
Herishanu, Y., Rogowski, O., Polliack, A., & Marilus, R. (2006) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2006.00658.x · Cited by 169 · see citing works
Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow
Suwa, T., Hogg, J. C., English, D. R., & van Eeden, S. F. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.6.h2954 · Cited by 169 · see citing works
Anemia in relation to body mass index and waist circumference among chinese women
Qin, Y., Melse‐Boonstra, A., Pan, X., et al. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-10 · Cited by 169 · see citing works
The relationship between obesity and hypoferraemia in adults: A systematic review
Cheng, H. L., Bryant, C., Cook, R., O'Connor, H., Rooney, K., & Steinbeck, K. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00938.x · Cited by 159 · see citing works
White Blood Cell Count in Women: Relation to Inflammatory Biomarkers, Haematological Profiles, Visceral Adiposity, and Other Cardiovascular Risk Factors
Farhangi, M. A., Keshavarz, S. A., Eshraghian, M., Ostadrahimi, A., & Saboor-Yaraghi, A.-A. (2013) · Journal of Health Population and Nutrition · doi:10.3329/jhpn.v31i1.14749 · Cited by 158 · see citing works
Obesity-Related Hypoferremia Is Not Explained by Differences in Reported Intake of Heme and Nonheme Iron or Intake of Dietary Factors that Can Affect Iron Absorption
Menzie, C. M., Yanoff, L. B., Denkinger, B. I., McHugh, T., Sebring, N. G., Calis, K. A., & Yanovski, J. A. (2007) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2007.10.034 · Cited by 154 · see citing works
Association of Fibrinogen and Coagulation Factors Vll and VIII with Cardiovascular Risk Factors in the Elderly: The Cardiovascular Health Study
Cushman, M., Yanez, D., Psaty, B. M., Fried, L. P., HEISS, G. M., Lee, M., Polak, J. F., Savage, P. J., Tracy, R. P., & Cardiovascular Health Study Investigators (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008799 · Cited by 139 · see citing works
Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men
Chu, N., Spiegelman, D. L., Hotamışlıgil, G. S., Rifai, N., Stampfer, M. J., & Rimm, E. B. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00755-3 · Cited by 138 · see citing works
Platelet Counts and Platelet Activation Markers in Obese Subjects
Samocha‐Bonet, D., Justo, D., Rogowski, O., Saar, N., Abu-Abeid, S., Shenkerman, G., Shapira, I., Berliner, S. A., & Tomer, A. (2008) · Mediators of Inflammation · doi:10.1155/2008/834153 · Cited by 137 · see citing works
Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People
Khan, A., Khan, W. M., Ayub, M., Humayun, M., & Haroon, M. (2016) · Journal of Obesity · doi:10.1155/2016/1937320 · Cited by 135 · see citing works
The acute phase protein response in patients receiving subcutaneous IL‐6
Banks, R., Forbes, M. A., Storr, M., Higginson, J., Thompson, D., Raynes, J., Illingworth, J., Perren, T., Selby, P., & Whicher, J. (1995) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb06659.x · Cited by 134 · see citing works
Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity
Murakami, T., Horigome, H., Tanaka, K., Nakata, Y., Ohkawara, K., Katayama, Y., & Matsui, A. (2006) · Thrombosis Research · doi:10.1016/j.thromres.2005.12.013 · Cited by 127 · see citing works
Nutrient deficiencies in patients with obesity considering bariatric surgery: A cross-sectional study
Lefebvre, P., Letois, F., Sultan, A., Nocca, D., Mura, T., & Galtier, F. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.10.003 · Cited by 126 · see citing works
Longitudinal changes in pancreatic and adipocyte hormones following Roux-en-Y gastric bypass surgery
Swarbrick, M. M., Stanhope, K. L., Austrheim-Smith, I. T., Loan, M. D. V., Ali, M. R., Wolfe, B. M., & Havel, P. J. (2008) · Diabetologia · doi:10.1007/s00125-008-1118-5 · Cited by 125 · see citing works
Excess Adiposity, Inflammation, and Iron-Deficiency in Female Adolescents
Tussing-Humphreys, L. M., Liang, H., Nemeth, E., Freels, S. A., & Braunschweig, C. A. (2009) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.10.044 · Cited by 122 · see citing works
Micronutrient deficiencies in morbidly obese women prior to bariatric surgery
Sánchez, A., Rojas, P., Basfi-fer, K., Carrasco, F., Inostroza, J., Codoceo, J., Valencia, A., Papapietro, K., Csendes, A., & Ruz, M. (2016) · Obesity Surgery · doi:10.1007/s11695-015-1773-9 · Cited by 119 · see citing works
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping
Sévère, N., Karabacak, M., Gustafsson, K. U., Baryawno, N., Courties, G., Kfoury, Y. S., Kokkaliaris, K. D., Rhee, C., Lee, D., Scadden, E. W., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.06.003 · Cited by 118 · see citing works
Chemoreflexes, Sleep Apnea, and Sympathetic Dysregulation
Mansukhani, M. P., Kara, T., Caples, S. M., & Somers, V. K. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0476-2 · Cited by 112 · see citing works
C-Reactive Protein Isoforms Differ in Their Effects on Thrombus Growth
Molins, B., Peña, E., Vilahur, G., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.174359 · Cited by 112 · see citing works
Thrombin generation in morbid obesity: significant reduction after weight loss
AY, L., KOPP, H. ‐., Brix, J., Ay, C., Quehenberger, P., Schernthaner, G.-H., Pabinger, I., & Schernthaner, G.-H. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03766.x · Cited by 110 · see citing works
In overweight and obese women, dietary iron absorption is reduced and the enhancement of iron absorption by ascorbic acid is one-half that in normal-weight women
Cepeda-Lopez, A. C., Melse‐Boonstra, A., Zimmermann, M. B., & Herter‐Aeberli, I. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.099218 · Cited by 110 · see citing works
Weight Loss Reduces Tissue Factor in Morbidly Obese Patients
Kopp, C. W., Kopp, H.-P., Steiner, S., Kriwanek, S., Krzyżanowska, K., Bartok, A., Roka, R., Minar, E., & Schernthaner, G. (2003) · Obesity Research · doi:10.1038/oby.2003.131 · Cited by 104 · see citing works
Inhibition of Endogenous Leptin Protects Mice From Arterial and Venous Thrombosis
Konstantinides, S., Schäfer, K., Neels, J. G., Dellas, C., & Loskutoff, D. J. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000146531.79402.9a · Cited by 103 · see citing works
Iron Metabolism in Genetically Obese (ob/ob) Mice
Failla, M. L., Kennedy, M. L., & Chen, M. L. (1988) · Journal of Nutrition · doi:10.1093/jn/118.1.46 · Cited by 101 · see citing works
The first ambulatory screening on thromboembolism: a multicentre, cross‐sectional, observational study on risk factors for venous thromboembolism
Minno, G. D., Mannucci, P. M., Tufano, A., Palareti, G., Moia, M., Baccaglini, U., Rudelli, G., & Giudici, G. A. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01458.x · Cited by 97 · see citing works
Association between Circulating Tumor Necrosis Factor-Alpha, Interleukin-6, and Insulin Resistance in Normal-Weight Women with Polycystic Ovary Syndrome
Tarkun, İ., Çetinarslan, B., Türemen, E., Cantürk, Z., & Biyikli, M. (2006) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2006.4.122 · Cited by 93 · see citing works
Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possible link between obesity and cardiovascular risk?
Napoleone, E., Santo, A. D., Amore, C., Baccante, G., Febbo, C. D., Porreca, E., de Gaetano, G., Donati, M. B., & Lorenzet, R. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02578.x · Cited by 93 · see citing works
Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity
村上, 卓. (2006) · Terrestrial Environment Research Center (University of Tsukuba) · Cited by 89 · see citing works
Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells
Singh, P., Peterson, T. E., Barber, K. R., Kuniyoshi, F. H. S., Jensen, A., Hoffmann, M. S., Shamsuzzaman, A., & Somers, V. K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.158 · Cited by 87 · see citing works
The prevalence of obstructive sleep apnoea in women with polycystic ovary syndrome: a systematic review and meta-analysis
Kahal, H., Kyrou, I., Uthman, O. A., Brown, A., Johnson, S., Wall, P. D. H., Metcalfe, A., Parr, D. G., Tahrani, A. A., & Randeva, H. S. (2020) · Sleep and Breathing · doi:10.1007/s11325-019-01835-1 · Cited by 87 · see citing works
Thrombopoietin Requires Additional Megakaryocyte-Active Cytokines for Optimal Ex Vivo Expansion of Megakaryocyte Precursor Cells
Williams, J. L., Pipia, G. G., Datta, N. S., et al. (1998) · Blood · doi:10.1182/blood.v91.11.4118 · Cited by 84 · see citing works
Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects
Tamminen, M., Lassila, R., Westerbacka, J., et al. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802312 · Cited by 81 · see citing works
Relation of the White Blood Cell Count to Obesity and Insulin Resistance: Effect of Race and Gender
Pratley, R. E., Wilson, C., & Bogardus, C. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00191.x · Cited by 81 · see citing works
Effect of Obesity on Platelet Reactivity and Response to Low-Dose Aspirin
Bordeaux, B. C., Qayyum, R., Yanek, L. R., Vaidya, D. M., Becker, L. C., Faraday, N. R., & Becker, D. M. (2009) · Preventive Cardiology · doi:10.1111/j.1751-7141.2009.00058.x · Cited by 80 · see citing works
Increases in Adiponectin Predict Improved Liver, but Not Peripheral, Insulin Sensitivity in Severely Obese Women During Weight Loss
Lin, E., Phillips, L. S., Ziegler, T. R., Schmotzer, B. J., Wu, K., Gu, L. H., Khaitan, L., Lynch, S. A., Torres, W. E., Smith, C. D., et al. (2007) · Diabetes · doi:10.2337/db06-1161 · Cited by 80 · see citing works
High concentration of leptin stimulates myeloid differentiation from human bone marrow CD34+ progenitors: potential involvement in leukocytosis of obese subjects
Laharrague, P. F., Oppert, J., Brousset, P., Charlet, J.-P., Campfield, A., Fontanilles, A. M., Guy-grand, B., Jx, C., Pénicaud, L., & Casteilla, L. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801377 · Cited by 79 · see citing works
Hepcidin Decreases Iron Transporter Expression in Vivo in Mouse Duodenum and Spleen and in Vitro in THP-1 Macrophages and Intestinal Caco-2 Cells
Chung, B., Chaston, T. B., Marks, J., Srai, S. K., & Sharp, P. (2009) · Journal of Nutrition · doi:10.3945/jn.108.102905 · Cited by 78 · see citing works
Regulation of tissue factor gene expression in obesity
Samad, F., Pandey, M., & Loskutoff, D. J. (2001) · Blood · doi:10.1182/blood.v98.12.3353 · Cited by 78 · see citing works
Leptin-dependent platelet aggregation in healthy, overweight and obese subjects
Corsonello, A., Perticone, F., Malara, A., Domenico, D. D., Loddo, S., Buemi, M., Ientile, R., & Corica, F. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802273 · Cited by 76 · see citing works
Glucose and insulin independently reduce the fibrinolytic potential of human vascular smooth muscle cells in culture
Pandolfi, A., Iacoviello, L., Capani, F., Vitacolonna, E., Donati, M. B., & Consoli, A. (1996) · Diabetologia · doi:10.1007/s001250050594 · Cited by 76 · see citing works
Obstructive sleep apnoea and polycystic ovary syndrome: A comprehensive review of clinical interactions and underlying pathophysiology
Kahal, H., Kyrou, I., Tahrani, A. A., & Randeva, H. S. (2017) · Clinical Endocrinology · doi:10.1111/cen.13392 · Cited by 70 · see citing works
Sustained improvement in blood lipids, coagulation, and fibrinolysis after major weight loss in obese subjects
Marckmann, P., Toubro, S., & Astrup, A. V. (1998) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600558 · Cited by 69 · see citing works
Anthropometric Measures of Obesity and Risk of Venous Thromboembolism
Borch, K. H., Brækkan, S. K., Mathiesen, E. B., Njølstad, I., Wilsgaard, T., Störmer, J., & Hansen, J. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.188920 · Cited by 67 · see citing works
Mean Platelet Volume Is Increased in Patients With Deep Vein Thrombosis
Gülcan, M. B., Varol, E., Etli, M., Aksoy, F., & Kayan, M. (2011) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029611427437 · Cited by 63 · see citing works
Relationship between obesity and iron deficiency anemia: is there a role of hepcidin?
Sal, E., Yenicesu, İ., Çelik, N., Paşaoğlu, H., Çelik, B., Paşaoğlu, Ö. T., Kaya, Z., Koçak, Ü., Camurdan, O. M., Bıdecı, A., et al. (2018) · Hematology · doi:10.1080/10245332.2018.1423671 · Cited by 63 · see citing works
Platelet Count and Mean Platelet Volume in Patients With In-Hospital Deep Venous Thrombosis
Çil, H., Yavuz, C., İslamoğlu, Y., et al. (2012) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029611435838 · Cited by 62 · see citing works
Body mass index, iron absorption and iron status in childbearing age women
Mujica-Coopman, M. F., Brito, A., López de Romaña, D., Pizarro, F., & Olivares, M. (2015) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.03.008 · Cited by 61 · see citing works
Relationship of the white blood cell count to body fat: role of leptin
Wilson, C. A., Bekele, G., Nicolson, M. A., Ravussin, É., & Pratley, R. E. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.3873201.x · Cited by 60 · see citing works
C‐reactive protein promotes platelet adhesion to endothelial cells: a potential pathway in atherothrombosis
Yaron, G., Brill, A. G., Dashevsky, O., Levi, I. M.-Y., Grad, E., Danenberg, H. D., & Varon, D. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06198.x · Cited by 59 · see citing works
Thrombosis in the setting of obesity or inflammatory bowel disease
Lentz, S. R. (2016) · Blood · doi:10.1182/blood-2016-05-716720 · Cited by 59 · see citing works
Adipokines and thrombosis
Schäfer, K., & Konstantinides, S. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05589.x · Cited by 56 · see citing works
The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea
Oyama, J., Nagatomo, D., Yoshioka, G., Yamasaki, A., Kodama, K., Sato, M., Komoda, H., Nishikido, T., Shiraki, A., & Node, K. (2015) · Journal of Cardiology · doi:10.1016/j.jjcc.2015.06.005 · Cited by 56 · see citing works
sP-selectin plasma levels in obesity: Association with insulin resistance and related metabolic and prothrombotic factors
Pergola, G. D., Pannacciulli, N., Coviello, M., Scarangella, A., Roma, P. D., Caringella, M., Venneri, M. T., Quaranta, M., & GIORGINO, R. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.09.010 · Cited by 56 · see citing works
Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNFα involvement
Rafail, S., Ritis, K., Schäfer, K., Kourtzelis, I., Speletas, M. G., Doumas, M. N., Giaglis, S., Kambas, K., Konstantinides, S., & Kartalis, G. (2008) · Thrombosis Research · doi:10.1016/j.thromres.2007.12.018 · Cited by 55 · see citing works
Greater blood volume and Hb mass in obese women quantified by the carbon monoxide-rebreathing method affects interpretation of iron biomarkers and iron requirements
Cepeda-Lopez, A. C., Zimmermann, M. B., Wussler, S., Melse‐Boonstra, A., Naef, N., Mueller, S. M., Toigo, M., & Herter‐Aeberli, I. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0127-9 · Cited by 53 · see citing works
Polycystic ovary syndrome and the peripheral blood white cell count
Herlihy, A., Kelly, R. E., Hogan, J. L., O’Connor, N., Farah, N., & Turner, M. J. (2011) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2011.553693 · Cited by 52 · see citing works
Niches for hematopoietic stem cells and immune cell progenitors
Sugiyama, T., Omatsu, Y., & Nagasawa, T. (2018) · International Immunology · doi:10.1093/intimm/dxy058 · Cited by 51 · see citing works
Interleukin-6 and megakaryocytopoiesis: an update
Baatout, S. (1996) · Annals of Hematology · doi:10.1007/s002770050220 · Cited by 49 · see citing works
Leucocytosis in women with polycystic ovary syndrome ( PCOS ) is incompletely explained by obesity and insulin resistance
Phelan, N., O’Connor, A. S., Tun, T. K., Correia, N., Boran, G. P., Roche, H. M., & Gibney, J. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04454.x · Cited by 48 · see citing works
Anemia Status in Relation to Body Mass Index Among Women of Childbearing Age in Bangladesh
Bishwajit, G., Yaya, S., & Tang, S. (2016) · Asia Pacific Journal of Public Health · doi:10.1177/1010539516660374 · Cited by 48 · see citing works
Soluble Interleukin-6 (IL-6) Receptor With IL-6 Stimulates Megakaryopoiesis From Human CD34+ Cells Through Glycoprotein (gp)130 Signaling
Sui, X., Tsuji, K., Ebihara, Y., Tanaka, R., Muraoka, K., Yoshida, M., Yamada, K., Yasukawa, K., Taga, T., Kishimoto, T., et al. (1999) · Blood · doi:10.1182/blood.v93.8.2525 · Cited by 47 · see citing works
C-reactive protein and atherothrombosis: Cause or effect?
Grad, E., & Danenberg, H. D. (2012) · Blood Reviews · doi:10.1016/j.blre.2012.12.001 · Cited by 47 · see citing works
Iron and Obesity in Females in the United States
Neymotin, F., & Sen, U. (2010) · Obesity · doi:10.1038/oby.2010.112 · Cited by 46 · see citing works
Relationship Between Body Weight and Total Leukocyte Count in Morbid Obesity
Nanji, A. A., & Freeman, J. B. (1985) · American Journal of Clinical Pathology · doi:10.1093/ajcp/84.3.346 · Cited by 46 · see citing works
Interleukin 8 (IL-8) and the Release of Leukocytes from the Bone Marrow
Eeden, S. E. V., & Terashima, T. (2000) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190009089427 · Cited by 43 · see citing works
Translational evidence of endothelial damage in obese individuals: inflammatory and prothrombotic responses
Hanzu, F. A., Palomo, M., Kalko, S. G., Párrizas, M., Garaulet, M., Escolar, G., Gomis, R., & Díaz‐Ricart, M. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04285.x · Cited by 43 · see citing works
Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity
Dellas, C., Schäfer, K., Rohm, I., Lankeit, M., Ellrott, T., Faustin, V., Riggert, J., Hasenfuss, G. P., & Konstantinides, S. (2008) · Thrombosis and Haemostasis · doi:10.1160/th08-05-0314 · Cited by 42 · see citing works
Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice
Pini, M., Rhodes, D., & Fantuzzi, G. (2011) · Cytokine · doi:10.1016/j.cyto.2011.09.015 · Cited by 41 · see citing works
Differences in Platelet Activation by Prolactin and Leptin
Wallaschofski, H., Kobsar, A., Sokolova, O. V., et al. (2004) · Hormone and Metabolic Research · doi:10.1055/s-2004-825727 · Cited by 40 · see citing works
Prevalence of Micronutrient Deficiencies Prior to Bariatric Surgery: Tehran Obesity Treatment Study (TOTS)
Asghari, G., Khalaj, A., Ghadimi, M., Mahdavi, M., Farhadnejad, H., Valizadeh, M., Azizi, F., Barzin, M., & Hosseinpanah, F. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3187-y · Cited by 39 · see citing works
Elevations in neutrophils with obstructive sleep apnea: The Multi-Ethnic Study of Atherosclerosis (MESA)
Geovanini, G. R., Wang, R., Weng, J. F., Tracy, R. P., Jenny, N. S., Goldberger, A. L., Costa, M. D., Liu, Y., Libby, P., & Redline, S. S. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.10.121 · Cited by 39 · see citing works
Inadequacies of micronutrient intake in normal weight and overweight young adults aged 18–25 years: a cross-sectional study
Farhat, G., Lees, E. A., Macdonald-Clarke, C. J., et al. (2019) · Public Health · doi:10.1016/j.puhe.2018.10.016 · Cited by 38 · see citing works
A high-fat diet increases interleukin-3 and granulocyte colony-stimulating factor production by bone marrow cells and triggers bone marrow hyperplasia and neutrophilia in wistar rats
do Carmo, L. S., Rogero, M. M., Paredes‐Gamero, E. J., et al. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213477976 · Cited by 37 · see citing works
Prevalence of electrolyte and nutritional deficiencies in Chinese bariatric surgery candidates
Wang, C., Guan, B., Yang, W., Yang, J., Cao, G., & Lee, S. (2015) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2015.12.009 · Cited by 37 · see citing works
Neutrophil-to-lymphocyte ratio in obstructive sleep apnea; a multi center, retrospective study.
Altıntaş, N., Çetinoğlu, E. D., Yüceege, M., Acet, A. N., Ursavaş, A., Fırat, H., & Karadağ, M. (2015) · PubMed · Cited by 36 · see citing works
Thrombopoietin Production in Wild-Type and Interleukin-6 Knockout Mice with Acute Inflammation
Burmester, H., Wolber, E., Freitag, P., Fandrey, J., & Jelkmann, W. (2005) · Journal of Interferon and Cytokine Research · doi:10.1089/jir.2005.25.407 · Cited by 34 · see citing works
Effect of bariatric surgery-induced weight loss on platelet count and mean platelet volume: a 12-month follow-up study
Raoux, L., Moszkowicz, D., Vychnevskaia, K., Poghosyan, T., Beauchet, A., Clauser, S., Bretault, M., Czernichow, S., Carette, C., & Bouillot, J.-L. (2017) · Obesity Surgery · doi:10.1007/s11695-016-2292-z · Cited by 34 · see citing works
Leptin Does Not Play a Major Role in Platelet Aggregation in Obesity and Leptin Deficiency
Özata, M., Avcu, F., Durmus, O., Yilmaz, I. M., Ozdemír, I. C., & Yalçın, A. (2001) · Obesity Research · doi:10.1038/oby.2001.82 · Cited by 33 · see citing works
Interleukin-6 and interleukin-11 act synergistically with thrombopoietin and stem cell factor to modulate ex vivo expansion of human CD41+ and CD61+ megakaryocytic cells.
Lazzari, L., Henschler, R., Lecchi, L., et al. (2000) · PubMed · Cited by 33 · see citing works
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Herter‐Aeberli, I., Thankachan, P., Bose, B., & Kurpad, A. V. (2015) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/s00394-015-1048-1 · Cited by 32 · see citing works
Leptin Enhances Adenosine Diphosphate‐Induced Platelet Aggregation in Healthy Subjects
Corsonello, A., Malara, A., Ientile, R., et al. (2002) · Obesity Research · doi:10.1038/oby.2002.42 · Cited by 28 · see citing works
Obesity with insulin resistance increase thrombosis in wild-type and bone marrow-transplanted Zucker fatty rats
Vera, R. H., Vilahur, G., & Badimón, L. (2012) · Thrombosis and Haemostasis · doi:10.1160/th12-09-0696 · Cited by 27 · see citing works
Obez olan ve olmayan OSAS’lı olgularda nötrofil lenfosit oranının önemi var mı?
Bozkuş, F., Dikmen, N., Samur, A. A., et al. (2018) · Tuberkuloz ve Toraks · doi:10.5578/tt.66535 · Cited by 27 · see citing works
The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea
Sünbül, M., Sünbül, E. A., Kanar, B. G., Yanartaş, Ö., Aydin, S., Bacak, A., Gulec, H., & Sari, I. (2015) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2015_125 · Cited by 25 · see citing works
Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects
Hankey, C., Rumley, A., Lowe, G. D. O., Woodward, M., & Lean, M. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800453 · Cited by 24 · see citing works
Obesity and iron-deficiency anemia in women of reproductive age in northern Iran
Rad, H. A., Sefidgar, S., Tamadoni, A., Sedaghat, S., Bakouei, F., Bijani, A., & Omidvar, S. (2019) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_371_18 · Cited by 21 · see citing works
Iron deficiency anemia and megaloblastic anemia in obese patients
Arshad, M., Jaberian, S., Pazouki, A., Riazi, S., Rangraz, M. A., & Mokhber, S. (2016) · Romanian Journal of Internal Medicine · doi:10.1515/rjim-2016-0046 · Cited by 20 · see citing works
Subcutaneous Adipose Tissue from Obese and Lean Adults Does Not Release HepcidinIn Vivo
Tussing-Humphreys, L. M., Frayn, K. N., Smith, S. R., Westerman, M. E., Dennis, A., Nemeth, E., Thomson, J. L., & Pusatcioglu, C. K. (2011) · The Scientific World JOURNAL · doi:10.1100/2011/634861 · Cited by 17 · see citing works
Relevance of Haematologic Parameters in Obese Women with or without Metabolic Syndrome
Raghavan, V. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/18779.7732 · Cited by 17 · see citing works
Does the neutrophil-to-lymphocyte ratio have any importance between subjects with obstructive sleep apnea syndrome with obesity and without obesity?
Bozkuş, F., Dikmen, N., & Samur, A. A. (2016) · doi:10.1183/13993003.congress-2016.pa2298 · Cited by 13 · see citing works
In prehypertension leukocytosis is associated with body mass index but not with blood pressure or incident hypertension
Julius, S., Egan, B. M., Kaciroti, N., Nesbitt, S. D., & Chen, A. K. (2013) · Journal of Hypertension · doi:10.1097/hjh.0000000000000032 · Cited by 12 · see citing works
Hematopoietic stem cell expansion caused by a synthetic fragment of leptin
Dias, C. C., Nogueira‐Pedro, A., Barbosa, C. M. V., Ribeiro-Filho, A. C., Wasinski, F., Araújo, R. C., de Oliveira, V. X., Miranda, A., & Paredes‐Gamero, E. J. (2013) · Peptides · doi:10.1016/j.peptides.2013.09.012 · Cited by 12 · see citing works
Iron Profile and Inflammatory Status of Overweight and Obese Women in Sari, North of Iran.
Shekarriz, R., & Vaziri, M. M. (2017) · Europe PMC (PubMed Central) · Cited by 11 · see citing works
Iron Deficiency and Obesity – Are we Diagnosing with Appropriate Indicators?
Monteiro, A. M., Fernandes, V., Matta-Coelho, C., Paredes, S., Pereira, M. L., Marques, O., & Alves, M. (2018) · Acta Médica Portuguesa · doi:10.20344/amp.8916 · Cited by 8 · see citing works
Effects of Leptin on Platelet Function in Obese Patients
Corica, F., Corsonello, A., & Perticone, F. (2002) · JAMA · doi:10.1001/jama.288.3.313 · Cited by 5 · see citing works

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Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide
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Authors: Purdy, J. C., & Shatzel, J. J.
Affiliations: Oregon Health & Science University (US)
Corresponding author: Purdy, Johanna C.
ORCID: Purdy, Johanna C.
Shatzel, Joseph J.
Venue: European Journal Of Haematology
Publisher: Wiley
Published: 2020-12-13
Volume: 106
Issue: 3
Pages: 306-319
ISSN: 0902-4441 (ISSN-L)
1600-0609
DOI: 10.1111/ejh.13560
PMC: PMC8086364
OpenAlex: W3106908788
Cited by: 227
References: 180
Citations by year: 2026: 43 · 2025: 51 · 2024: 54 · 2023: 52 · 2022: 19 · 2021: 8
FWCI: 2.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: European Journal Of Haematology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL151367)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords: obesity, hematological parameters, low-grade inflammation, leukocytosis, platelet count, venous thromboembolism, thrombosis risk, iron deficiency, red blood cell count, leukocytes
MeSH terms: Adipose Tissue, Animals, Disease Susceptibility, Humans, Inflammation, Leukocyte Count, Leukocytosis, Obesity, Sex Factors, Biomarkers, Cytokines, Inflammation Mediators

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The hematologic consequences of obesity

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