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Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria
Abstract
Mitochondria contribute to myocyte injury during ischemia. After 30 and 45 min of ischemia in the isolated perfused rabbit heart, subsarcolemmal mitochondria (SSM), located beneath the plasma membrane, sustain a decrease in oxidative phosphorylation through cytochrome oxidase. In contrast, oxidation through cytochrome oxidase in interfibrillar mitochondria (IFM), located between the myofibrils, remains unaffected. Cytochrome oxidase activity in the intact membrane requires an inner mitochondrial membrane lipid environment enriched in cardiolipin. During ischemia, the content of cardiolipin decreased only in SSM, whereas the content of other phospholipids was preserved. Ischemia did not alter the composition of the cardiolipin that remained in SSM. Cardiolipin content was preserved in IFM during ischemia. Thus cardiolipin is a relatively early target of ischemic mitochondrial damage, leading to loss of oxidative phosphorylation through cytochrome oxidase in SSM.
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Cited by
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Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure
Lesnefsky, E. J., Moghaddas, S., Tandler, B., Kerner, J., & Hoppel, C. L. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1378 · Cited by 709
Self-citationSzeto, H. H. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12461 · Cited by 548
Birk, A. V., Liu, S., Soong, Y., Mills, W., Singh, P., Warren, J. D., Seshan, S. V., Pardee, J. D., & Szeto, H. H. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012121216 · Cited by 479
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Metadata
- Authors
- Lesnefsky, E. J., Slabe, T. J., Stoll, M. S. K., Minkler, P. E., & Hoppel, C. L.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2001-06-01
- Volume
- 280
- Issue
- 6
- Pages
- H2770-H2778
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2339736327
- Cited by
- 194
- References
- 0
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lesnefsky, E. J., Slabe, T. J., Stoll, M. S. K., Minkler, P. E., & Hoppel, C. L. (2001). Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.2001.280.6.h2770
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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