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Hemodynamic Determinants of Oxygen Consumption of the Heart With Special Reference to the Tension-Time Index
Abstract
The hemodynamic determinants of myocardial oxygen utilization were ascertained in the isolated, metabolically supported, nonfailing canine heart. The primary determinant was found to be the total tension developed by the myocardium as indicated by the area beneath the systolic pressure curve (Tension-Time Index). The significance of these findings for the understanding of the low efficiency of the failing heart and the consequently increased importance of Laplace's law are discussed.
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Citations
Cited by
Role of Blood Pressure in the Development of Congestive Heart Failure: The Framingham Study
Kannel, W. B., Castelli, W. P., McNamara, P. M., McKee, P. A., & Feinleib, M. (1972) · New England Journal of Medicine · doi:10.1056/nejm197210192871601 · Cited by 603
Naughton, M. T., Rahman, M. A., Hara, K., Floras, J. S., & Bradley, T. D. (1995) · Circulation · doi:10.1161/01.cir.91.6.1725 · Cited by 466
Coronary circulation in dogs with an experimental decrease in aortic compliance
Watanabe, H., Ohtsuka, S., Kakihana, M., & Sugishita, Y. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90330-4 · Cited by 278
The First Open Heart Corrections of Tetralogy of Fallot: A 26–31 Year Follow-up of 106 Patients
LILLEHEI, C. W., VARCO, R. L., COHEN, M., WARDEN, H. E., GOTT, V. L., DEWALL, R. A., PATTON, C., & MOLLER, J. H. (1986) · Annals of Surgery · doi:10.1097/00000658-198610000-00017 · Cited by 168
Myocardial Injury and Cardiac Reserve in Patients With Heart Failure and Preserved Ejection Fraction
Obokata, M., Reddy, Y. N. V., Melenovsky, V., Kane, G. C., Olson, T. P., Jarolim, P., & Borlaug, B. A. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.04.039 · Cited by 151
Metadata
- Authors
- Sarnoff, S. J., Braunwald, E., Welch, G. H., Case, R. B., Stainsby, W. N., & Macruz, R.
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1957-12-31
- Volume
- 192
- Issue
- 1
- Pages
- 148-156
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2270287237
- Cited by
- 1,319
- References
- 0
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hemodynamic Determinants of Oxygen Consumption of the Heart With Special Reference to the Tension-Time Index. https://app.cochat.ai/papers/10.1152/ajplegacy.1957.192.1.148
- The paper
- Sarnoff, S. J., Braunwald, E., Welch, G. H., Case, R. B., Stainsby, W. N., & Macruz, R. (1957). Hemodynamic Determinants of Oxygen Consumption of the Heart With Special Reference to the Tension-Time Index. American Journal of Physiology-Legacy Content. https://doi.org/10.1152/ajplegacy.1957.192.1.148
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
