Interaction of central and peripheral factors in physiological temperature regulation
Abstract
To evaluate the relative importance of central and peripheral factors in physiological temperature regulation, calorimetric measurements of thermal and metabolic responses in the unanesthetized dog to localized heating of the supraoptic and preoptic regions were made at various environmental temperatures. At all temperatures, heating the hypothalamus caused an imbalance in the over-all heat exchange, and lowered core temperature by 0.8°–1.0°C. In a neutral environment, this was effected by a 30–40% depression of the resting rate of heat production. In a cool environment, heating inhibited shivering so that heat production, relative to heat loss, was low. In a warm environment, vigorous panting and vasodilatation were elicited, thereby increasing heat loss. On cessation of heating, shivering occurred in response to the lowered core temperature, but differed in intensity depending upon the peripheral thermal drive. Reapplication of heating suppressed shivering in all cases. From these data some quantitative estimates were made of the sensitivity of the hypothalamic thermoregulatory ‘centers’, and of the interaction and relative contributions of central and peripheral control.
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Local changes in the hypothalamus can override temperature modification at the extremities, suggesting tight coupling of brain and body temperature.
“Interestingly, although the external environment is the most likely cause for the initiation of thermoregulatory processes, local changes in the hypothalamus can override any temperature modification at the extremities of the body, suggesting a tight coupling of brain and body temperature [35].”
From Human thermal perception and time of day: A review (2021) · cites this paper as [35]
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- Authors
- Fusco, M. M., Hardy, J. D., & Hammel, H. T.
- Affiliations
- University of Pennsylvania (US)
- ORCID
- Hardy, J. D.
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1961-03-01
- Volume
- 200
- Issue
- 3
- Pages
- 572-580
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2279506204
- Cited by
- 92
- References
- 0
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 2
- FWCI
- 14.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Legacy Content (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- thermoregulation, hypothalamus, preoptic area, shivering, panting, vasodilation, thermogenesis, heat loss, core body temperature, ambient temperature, thermoregulatory center
- MeSH terms
- Body Temperature, Central Nervous System, Humans, Nervous System Physiological Phenomena, Peripheral Nerves, Temperature
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