Metabolic fate of leucine: a significant sterol precursor in adipose tissue and muscle
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BCAAs are critical bioenergetic substrates for muscle and other tissues, particularly in the fasted state.
“Whereas glutamine is an important substrate for proliferating cells, BCAAs are critical bioenergetic substrates for muscle and other tissues, particularly in the fasted state (Rosenthal et al., 1974).”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Rosenthal et al., 1974
Cites
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Self-citationα-Aminoisobutyric acid uptake in isolated mouse fat cells
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Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
Green, C. R., Wallace, M., Divakaruni, A. S., Phillips, S. A., Murphy, A. N., Ciaraldi, T. P., & Metallo, C. M. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.1961 · Cited by 471 · see citing works
Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier
Vacanti, N. M., Divakaruni, A. S., Green, C. R., Parker, S. J., Henry, R. R., Ciaraldi, T. P., Murphy, A. N., & Metallo, C. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.024 · Cited by 277 · see citing works
- Authors
- Rosenthal, J., Angel, A., & Farkas, J.
- ORCID
- Farkas, J
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1974-02-01
- Volume
- 226
- Issue
- 2
- Pages
- 411-418
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2345412552
- Cited by
- 134
- References
- 20
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 4 · 2012: 14
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Legacy Content (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- leucine metabolism, sterol precursors, adipose tissue, skeletal muscle, cholesterol biosynthesis, amino acid metabolism
- MeSH terms
- Adipose Tissue, Animals, Carbon Dioxide, Carbon Radioisotopes, Chromatography, Thin Layer, Fatty Acids, Glucose, Humans, Insulin, Leucine, Lipids, Liver, Male, Muscles, Sterols, Protein Biosynthesis, Tritium, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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