Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus
Abstract
Oxidants and neutrophils contribute to lung injury during influenza A virus (IAV) infection. Surfactant protein (SP)-D plays a pivotal role in restricting IAV replication and inflammation in the first several days after infection. Despite its potent anti-inflammatory effects in vivo, preincubation of IAV with SP-D in vitro strongly increases neutrophil respiratory burst responses to the virus. Several factors are shown to modify this apparent proinflammatory effect of SP-D. Although multimeric forms of SP-D show dose-dependent augmentation of respiratory burst responses, trimeric, single-arm forms either show no effect or inhibit these responses. Furthermore, if neutrophils are preincubated with multimeric SP-D before IAV is added, oxidant responses to the virus are significantly reduced. The ability of SP-D to increase neutrophil uptake of IAV can be dissociated from enhancement of oxidant responses. Finally, several other innate immune proteins that bind to SP-D and/or IAV (i.e., SP-A, lung glycoprotein-340 or mucin) significantly reduce the ability of SP-D to promote neutrophil oxidant response. As a result, the net effect of bronchoalveolar lavage fluids is to increase neutrophil uptake of IAV while reducing the respiratory burst response to virus.
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In both scenarios, function of the effector cells is impaired by influenza virus infection, so only the harmful effects of the inflammatory response are realized.
“In both scenarios, function of the effector cells is impaired by influenza virus infection, so only the harmful effects of the inflammatory response are realized [33,[44][45][46].”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [45]
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Influenza virus primes mice for pneumonia from Staphylococcus aureus.
Iverson, A. R., Boyd, K. L., McAuley, J. L., Plano, L. R., Hart, M. E., & McCullers, J. A. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq113 · Cited by 168 · see citing works
- Authors
- White, M. R., Crouch, E., Vesona, J., Tacken, P. J., Batenburg, J. J., Leth-Larsen, R., Holmskov, U., & Hartshorn, K. L.
- Affiliations
- Boston University (US)
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2005-10
- Volume
- 289
- Issue
- 4
- Pages
- L606-L616
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W2139266182
- Cited by
- 61
- References
- 50
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Lung Cellular and Molecular Physiology (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL029594, R01HL044015, HL- 44015, HL-69031, HL 29594, R01HL069031)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Keywords
- influenza A virus, surfactant protein D, neutrophils, respiratory burst, innate immunity, surfactant protein A, mucin, neutrophil phagocytosis, lung injury, bronchoalveolar lavage fluid
- MeSH terms
- Animals, Bronchoalveolar Lavage Fluid, Chick Embryo, Cricetinae, Humans, Hydrogen Peroxide, Influenza, Human, Lung, Neutrophils, Influenza A virus, Receptors, Immunologic, Recombinant Proteins, CHO Cells, Respiratory Burst, Pulmonary Surfactant-Associated Protein A, Pulmonary Surfactant-Associated Protein D
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