The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
β-Catenin regulates differentiation of respiratory epithelial cells in vivo
Abstract
An activated form of β-catenin [Catnb Δ(ex3)] was expressed in respiratory epithelial cells of the developing lung. Although morphogenesis was not altered at birth, air space enlargement and epithelial cell dysplasia were observed in the early postnatal period and persisted into adulthood. The Catnb Δ(ex3)protein caused squamous, cuboidal, and goblet cell dysplasia in intrapulmonary conducting airways. Atypical epithelial cells that stained for surfactant pro protein C (pro-SP-C) and had morphological characteristics of alveolar type II cells were observed in bronchioles of the transgenic mice. Catnb Δ(ex3)inhibited expression of Foxa2 and caused goblet cell hyperplasia associated with increased staining for mucins and the MUC5A/C protein. In vitro, both wild type and activated β-catenin negatively regulated the expression of the Foxa2 promoter. Catnb Δ(ex3)also caused pulmonary tumors in adult mice. Activation of β-catenin caused ectopic differentiation of alveolar type II-like cells in conducting airways, goblet cell hyperplasia, and air space enlargement, demonstrating a critical role for the Wnt/β-catenin signal transduction pathway in the differentiation of the respiratory epithelium in the postnatal lung.
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Citations
Cites
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Cited by
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Jacob, A., Morley, M., Hawkins, F., McCauley, K. B., Jean, J. C., Heins, H., Na, C.-L., Weaver, T. E., Vedaie, M., Hurley, K., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.08.014 · Cited by 565
Self-citationGrigoryan, T., Wend, P., Klaus, A., & Birchmeier, W. (2008) · Genes & Development · doi:10.1101/gad.1686208 · Cited by 560
Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis
Königshoff, M., Balsara, N., Pfaff, E.-M., Kramer, M., Chrobak, I., Seeger, W., & Eickelberg, O. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002142 · Cited by 507
Transcriptional Control of Lung Morphogenesis
Maeda, Y., Davé, V., & Whitsett, J. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00028.2006 · Cited by 473
Self-citationInhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
Henderson, W. R., Chi, E. Y., Ye, X., Nguyen, C., Tien, Y.-T., Zhou, B., Borok, Z., Knight, D. A., & Kahn, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001520107 · Cited by 462
Metadata
- Authors
- Mucenski, M. L., Nation, J. M., Thitoff, A. R., Besnard, V., Xu, Y., Wert, S. E., Harada, N., Taketo, M. M., Stahlman, M. T., & Whitsett, J. A.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2005-12
- Volume
- 289
- Issue
- 6
- Pages
- L971-L979
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W2129296802
- Cited by
- 164
- References
- 1
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mucenski, M. L., Nation, J. M., Thitoff, A. R., Besnard, V., Xu, Y., Wert, S. E., Harada, N., Taketo, M. M., Stahlman, M. T., & Whitsett, J. A. (2005). β-Catenin regulates differentiation of respiratory epithelial cells in vivo. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00172.2005
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