Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction

Reynolds, Susan D.; Giangreco, Adam; Hong, Kyung U.; McGrath, Kathleen E.; Ortiz, Luis A.; Stripp, Barry R.

doi:10.1152/ajplung.00203.2004

Cited by 86Neonatal Respiratory Health ResearchChronic Obstructive Pulmonary Disease (COPD) ResearchInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction

Reynolds, Susan D., Giangreco, Adam, Hong, Kyung U., McGrath, Kathleen E., Ortiz, Luis A., Stripp, Barry R.·2004·American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI 10.1152/ajplung.00203.2004

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Abstract

Identification of early events that contribute to the establishment of chronic lung disease has been complicated by the variable involvement of the airway and alveolar compartments in the complex physiology of end-stage disease. In particular, the impact of airway injury on alveolar integrity and function has not been addressed and would be facilitated by development of animal models of lung disease that specifically target a single cell type within the airway epithelium. We have previously demonstrated that ganciclovir treatment of CCtk transgenic mice, which express the herpes simplex thymidine kinase gene under regulation of the mouse Clara cell secretory protein (CCSP) promoter, results in elimination of the airway progenitor and stem cell pools and a consequent failure of airway regeneration that is associated with rapid morbidity and mortality. In this study, we used the CCtk model to test the hypothesis that selective airway injury initiates profound lung dysfunction through mechanisms that compromise alveolar integrity. Results demonstrate that elimination of the CCSP-expressing cell population results in secondary alveolar inflammation, edema, and depletion of the alveolar type II cell population. On the basis of these data we conclude that selective airway injury can serve as the inciting injury in diseases characterized by severely compromised alveolar function.

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Loss of basal cells precludes regeneration of the airway epithelium, resulting in sustained respiratory compromise.
“Loss of basal cells precludes regeneration of the airway epithelium, resulting in sustained respiratory compromise (41).”
From Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19 (2021) · cites this paper as [41]

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Airway Regeneration Is Delayed By Prior Depletion Of Bone Marrow Clara Cell Secretory Protein-expressing Cells
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Authors: Reynolds, S. D., Giangreco, A., Hong, K. U., McGrath, K. E., Ortiz, L. A., & Stripp, B. R.
Affiliations: University of Pittsburgh (US)
ORCID: Reynolds, Susan D.
Giangreco, Adam
Hong, Kyung U.
McGrath, Kathleen E.
Ortiz, Luis A.
Stripp, Barry R.
Venue: American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher: American Physiological Society
Published: 2004-12
Volume: 287
Issue: 6
Pages: L1256-L1265
ISSN: 1040-0605 (ISSN-L)
1522-1504
DOI: 10.1152/ajplung.00203.2004
OpenAlex: W2159042249
Cited by: 86
References: 34
Citations by year: 2024: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 5
FWCI: 5.81
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Lung Cellular and Molecular Physiology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL64888, R01HL070575, HL-70575, R01HL064888)
National Institute of Environmental Health Sciences (R01ES008964, R01ES010859, ES10859, ES08964)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Keywords: airway injury, Clara cell secretory protein, airway stem cells, airway progenitor cells, alveolitis, alveolar type II cells, airway regeneration, ganciclovir, chronic lung disease, alveolar edema
MeSH terms: Animals, Antiviral Agents, Body Weight, Bronchoalveolar Lavage Fluid, Cell Division, Inflammation, Lung Diseases, Mice, Transgenic, Pulmonary Alveoli, RNA, Messenger, Stem Cells, Thymidine Kinase, Ganciclovir, Gene Expression Regulation, Enzymologic, Simplexvirus, Pulmonary Surfactant-Associated Protein C, Mice

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Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction

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