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Cited by 140Smoking Behavior and CessationCarcinogens and Genotoxicity AssessmentChronic Obstructive Pulmonary Disease (COPD) Research

Biomarkers of exposure to new and emerging tobacco delivery products

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Schick, Suzaynn F., Blount, Benjamin C., Jacob, Peyton, Saliba, Najat A., Bernert, John T., El Hellani, Ahmad, Jatlow, Peter, Pappas, R. Steven +16 more·2017·American Journal of Physiology-Lung Cellular and Molecular Physiology
DOI 10.1152/ajplung.00343.2016PMC PMC5626373
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Abstract

Accurate and reliable measurements of exposure to tobacco products are essential for identifying and confirming patterns of tobacco product use and for assessing their potential biological effects in both human populations and experimental systems. Due to the introduction of new tobacco-derived products and the development of novel ways to modify and use conventional tobacco products, precise and specific assessments of exposure to tobacco are now more important than ever. Biomarkers that were developed and validated to measure exposure to cigarettes are being evaluated to assess their use for measuring exposure to these new products. Here, we review current methods for measuring exposure to new and emerging tobacco products, such as electronic cigarettes, little cigars, water pipes, and cigarillos. Rigorously validated biomarkers specific to these new products have not yet been identified. Here, we discuss the strengths and limitations of current approaches, including whether they provide reliable exposure estimates for new and emerging products. We provide specific guidance for choosing practical and economical biomarkers for different study designs and experimental conditions. Our goal is to help both new and experienced investigators measure exposure to tobacco products accurately and avoid common experimental errors. With the identification of the capacity gaps in biomarker research on new and emerging tobacco products, we hope to provide researchers, policymakers, and funding agencies with a clear action plan for conducting and promoting research on the patterns of use and health effects of these products.

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Crossref · 10.1152/ajplung.00343.2016

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6 of 6 references verified0 citation errors · 0 not checkable

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  • Serum cotinine can serve as a reliable indicator of smoking intensity and tobacco smoke exposure.

    “Serum cotinine, a primary metabolite of nicotine, is directly proportional to the extent of tobacco smoke exposure and can serve as a reliable indicator of smoking intensity and tobacco smoke exposure18,19.”

    From Association between serum cotinine and total testosterone in adult males based on NHANES 2011–2016 (2024) · cites this paper as [19]

  • Serum cotinine is directly proportional to the extent of tobacco smoke exposure.

    “Serum cotinine, a primary metabolite of nicotine, is directly proportional to the extent of tobacco smoke exposure and can serve as a reliable indicator of smoking intensity and tobacco smoke exposure18,19.”

    From Association between serum cotinine and total testosterone in adult males based on NHANES 2011–2016 (2024) · cites this paper as [19]

  • Cotinine in biological fluids can be measured as a reliable marker of nicotine exposure.

    “To examine nicotine exposure, levels of cotinine in biological fluids can be measured as a reliable marker. 14”

    From Decreased sperm counts in Swedish users of oral tobacco (2022) · cites this paper as [14]

  • Cotinine is not a perfect marker of exposure, due to inter-individual variations in metabolism.

    “Cotinine is not a perfect marker of exposure, due to inter‐individual variations in metabolism. 14”

    From Decreased sperm counts in Swedish users of oral tobacco (2022) · cites this paper as [14]

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Authors
Schick, S. F., Blount, B. C., Jacob, P., Saliba, N. A., Bernert, J. T., El Hellani, A., Jatlow, P., Pappas, R. S., Wang, L., Foulds, J., Ghosh, A., Hecht, S. S., Gomez, J. C., Martin, J. R., Mesaros, C., Srivastava, S., St. Helen, G., Tarran, R., Lorkiewicz, P. K., Blair, I. A., Kimmel, H. L., Doerschuk, C. M., Benowitz, N. L., & Bhatnagar, A.
Affiliations
  • University of California, San Francisco (US)
  • Centers for Disease Control and Prevention (US)
  • Virginia Commonwealth University (US)
  • Department of Chemistry, American University of Beirut, Beirut, Lebanon;
  • Yale University (US)
  • Pennsylvania State University (US)
  • University of North Carolina at Chapel Hill (US)
  • University of Minnesota (US)
  • University of Pennsylvania (US)
  • University of Louisville (US)
  • Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, California;
  • National Institutes of Health (US)
  • American Heart Association (US)
Corresponding author
Schick, Suzaynn F.
ORCID
Venue
American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher
American Physiological Society
Published
2017-09-01
Volume
313
Issue
3
Pages
L425-L452
ISSN
  • 1040-0605 (ISSN-L)
  • 1522-1504
DOI
10.1152/ajplung.00343.2016
PMC
PMC5626373
OpenAlex
W2614141206
Cited by
140
References
6
Citations by year
2026: 15 · 2025: 13 · 2024: 19 · 2023: 18 · 2022: 14 · 2021: 25 · 2020: 10 · 2019: 12 · 2018: 11 · 2017: 3
FWCI
1.20
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Lung Cellular and Molecular Physiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by-nc-sa)
  • UNC Libraries
Funders
HHS | NIH | Office of Disease Prevention (P50 CA180890-01, P50 DA036151, P50 DA036105, R21 DA038775, P42E S023720, P30 ES013508, U54 HL117798, P50 HL120163, P50 DA036107, P50 HL120100, R01 HL120746)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
biomarkers of exposure, electronic cigarettes, little cigars, hookah, cigarillos, exposure assessment, biomarker validation
MeSH terms
Environmental Exposure, Humans, Nicotine, Nicotiana, Biomarkers, Metabolome, Electronic Nicotine Delivery Systems

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