The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Endothelial dysfunction in pulmonary arteries of patients with mild COPD
Abstract
To investigate whether endothelial dysfunction of pulmonary arteries (PA) is present in patients with mild chronic obstructive pulmonary disease (COPD) and to what extent it is related to the morphological abnormalities of PA, we studied 41 patients who underwent lung resection. Patients were divided into the following groups: nonsmokers ( n = 7), smokers with normal lung function ( n = 13), and COPD ( n = 21). Endothelium-dependent relaxation mediated by nitric oxide was evaluated in vitro in PA rings exposed to cumulative concentrations of acetylcholine (ACh) and ADP. Structural abnormalities of PA were assessed morphometrically. PA of COPD patients developed lower maximal relaxation in response to ADP than both nonsmokers and smokers ( P < 0.05 each) and a trend to reduced relaxation in response to ACh ( P = 0.08). Maximal relaxation to ADP correlated with the degree of airflow obstruction ( r = 0.48, P < 0.01). Morphometrical analysis of PA revealed thicker intimas, especially in small arteries, in both smokers and COPD compared with nonsmokers ( P < 0.05 each). We conclude that endothelial dysfunction of PA is already present in patients with mild COPD. In these patients, as well as in smokers with normal lung function, small arteries show thickened intimas, suggesting that tobacco consumption may play a critical role in the pathogenesis of pulmonary vascular abnormalities in COPD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,029
ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91481-4 · Cited by 1,437
Giaid, A., & Saleh, D. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507273330403 · Cited by 1,369
The Relations between Structural Changes in Small Airways and Pulmonary-Function Tests
Cosio, M., Ghezzo, H., Hogg, J. C., Corbin, R., Loveland, M., Dosman, J., & Macklem, P. T. (1978) · New England Journal of Medicine · doi:10.1056/nejm197806082982303 · Cited by 880
Passive Smoking and Impaired Endothelium-Dependent Arterial Dilatation in Healthy Young Adults
Celermajer, D. S., Adams, M. R., Clarkson, P., Robinson, J., McCredie, R., Donald, A., & Deanfield, J. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601183340303 · Cited by 690
Clancy, R. M., Leszczynska-Piziak, J., & Abramson, S. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115929 · Cited by 686
Tuder, R. M., Flook, B. E., & Voelkel, N. F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117858 · Cited by 588
Impairment of Endothelium-Dependent Pulmonary-Artery Relaxation in Chronic Obstructive Lung Disease
Dinh-Xuan, A. T., Higenbottam, T. W., Clelland, C. A., Pepke-Zaba, J., Cremona, G., Butt, A. Y., Large, S. R., Wells, F. C., & Wallwork, J. (1991) · New England Journal of Medicine · doi:10.1056/nejm199105303242203 · Cited by 528
The Effect of Cigarette Smoking on Neutrophil Kinetics in Human Lungs
MacNee, W., Wiggs, B., Belzberg, A. S., & Hogg, J. C. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910053211402 · Cited by 284
Barberà, J. A., Riverola, A., Roca, J., Ramirez, J., Wagner, P. D., Ros, D., Wiggs, B. R., & Rodriguez-Roisin, R. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.2.8306040 · Cited by 260
Self-citation
Cited by
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Self-citationInflammation, Growth Factors, and Pulmonary Vascular Remodeling
Hassoun, P. M., Mouthon, L., Barberà, J. A., Eddahibi, S., Flores, S. C., Grimminger, F., Jones, P. L., Maitland, M. L., Michelakis, E. D., Morrell, N. W., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.006 · Cited by 710
Self-citationCellular and Structural Bases of Chronic Obstructive Pulmonary Disease
SAETTA, M., TURATO, G., MAESTRELLI, P., MAPP, C. E., & FABBRI, L. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.6.2009116 · Cited by 552
CD8 + ve Cells in the Lungs of Smokers with Chronic Obstructive Pulmonary Disease
SAETTA, M., BARALDO, S., CORBINO, L., TURATO, G., BRACCIONI, F., REA, F., CAVALLESCO, G., TROPEANO, G., MAPP, C. E., MAESTRELLI, P., et al. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.2.9812020 · Cited by 489
King, P. T. (2015) · Clinical and Translational Medicine · doi:10.1186/s40169-015-0068-z · Cited by 269
Metadata
- Authors
- Peinado, V. I., Barberà, J. A., Ramírez, J., Gómez, F. P., Roca, J., Jover, L., Gimferrer, J. M., & Rodriguez-Roisin, R.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 1998-06-01
- Volume
- 274
- Issue
- 6
- Pages
- L908-L913
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W2343934094
- Cited by
- 334
- References
- 28
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Endothelial dysfunction in pulmonary arteries of patients with mild COPD. https://app.cochat.ai/papers/10.1152/ajplung.1998.274.6.l908
- The paper
- Peinado, V. I., Barberà, J. A., Ramírez, J., Gómez, F. P., Roca, J., Jover, L., Gimferrer, J. M., & Rodriguez-Roisin, R. (1998). Endothelial dysfunction in pulmonary arteries of patients with mild COPD. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.1998.274.6.l908
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
