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Cited by 260

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive pulmonary disease.

Barberà, J A, Riverola, A, Roca, J, Ramirez, J, Wagner, P D, Ros, D, Wiggs, B R, Rodriguez-Roisin, R·1994·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/ajrccm.149.2.8306040
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Abstract

Morphologic changes in pulmonary muscular arteries may modify the mechanisms that regulate the pulmonary vascular tone and contribute to maintaining an adequate ventilation-perfusion (VA/Q) matching in patients with chronic obstructive pulmonary disease (COPD). To analyze the relationships between the abnormalities of pulmonary muscular arteries and the degree of VA/Q inequality, and to assess the effect of these abnormalities on the changes in VA/Q relationships induced by oxygen breathing, we studied a group of patients with mild COPD undergoing resective lung surgery. According to the degree of airflow obstruction and the increase in VA/Q mismatch produced by 100% O2 breathing (delta logSD Q), patients were divided into three groups: (A) patients with normal lung function, (B) patients with airflow obstruction and a high response to oxygen (delta logSD Q > 0.4), and (C) patients with airflow obstruction and a low response to oxygen (delta logSD Q < 0.4). Pulmonary arteries in Groups B and C showed narrower lumens and thicker walls than in Group A. These morphologic changes were produced mainly by an enlargement of the intimal layer and were more pronounced in Group C than in Group B. The assessment of intimal area as a function of artery diameter showed that the increase in intima in Group C took place predominantly in arteries with small diameters (< 500 microns). The mean intimal area on each subject correlated with both the PaO2 value (r = -0.46, p < 0.05) and the overall index of VA/Q mismatching (r = 0.51, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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Metadata

Authors
Barberà, J. A., Riverola, A., Roca, J., Ramirez, J., Wagner, P. D., Ros, D., Wiggs, B. R., & Rodriguez-Roisin, R.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
1994-02
Volume
149
Issue
2
Pages
423-429
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/ajrccm.149.2.8306040
OpenAlex
W2053205239
Cited by
260
References
20
FWCI
6.07
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive pulmonary disease. https://app.cochat.ai/papers/10.1164/ajrccm.149.2.8306040
The paper
Barberà, J. A., Riverola, A., Roca, J., Ramirez, J., Wagner, P. D., Ros, D., Wiggs, B. R., & Rodriguez-Roisin, R. (1994). Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.149.2.8306040

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.