The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
Open accessAbstract
AMP-activated protein kinase (AMPK) is activated by increases in the intracellular AMP-to-ATP ratio and plays a central role in cellular responses to metabolic stress. Although activation of AMPK has been shown to have anti-inflammatory effects, there is little information concerning the role that AMPK may play in modulating neutrophil function and neutrophil-dependent inflammatory events, such as acute lung injury. To examine these issues, we determined the effects of pharmacological activators of AMPK, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) and barberine, on Toll-like receptor 4 (TLR4)-induced neutrophil activation. AICAR and barberine dose-dependently activated AMPK in murine bone marrow neutrophils. Exposure of LPS-stimulated neutrophils to AICAR or barberine inhibited release of TNF-α and IL-6, as well as degradation of IκBα and nuclear translocation of NF-κB, compared with findings in neutrophil cultures that contained LPS without AICAR or barberine. Administration of AICAR to mice resulted in activation of AMPK in the lungs and was associated with decreased severity of LPS-induced lung injury, as determined by diminished neutrophil accumulation in the lungs, reduced interstitial pulmonary edema, and diminished levels of TNF-α and IL-6 in bronchoalveolar lavage fluid. These results suggest that AMPK activation reduces TLR4-induced neutrophil activation and diminishes the severity of neutrophil-driven proinflammatory processes, including acute lung injury.
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Cites
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Cited by
Metabolism of Inflammation Limited by AMPK and Pseudo-Starvation
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Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase
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Self-citation
Metadata
- Authors
- Zhao, X., Zmijewski, J. W., Lorne, E., Liu, G., Park, Y.-J., Tsuruta, Y., & Abraham, E.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2008-09
- Volume
- 295
- Issue
- 3
- Pages
- L497-L504
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W2145417168
- Cited by
- 301
- References
- 11
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhao, X., Zmijewski, J. W., Lorne, E., Liu, G., Park, Y.-J., Tsuruta, Y., & Abraham, E. (2008). Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.90210.2008
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