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AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila
Abstract
Adipokinetic hormone (AKH) is a metabolic neuropeptide principally known for its mobilization of energy substrates, notably lipid and trehalose during energy-requiring activities, such as flight and locomotion. Drosophila melanogaster AKH cell localization in corpora cardiaca, as in other insect species, was confirmed by immunoreactivity and by a genetic approach using the UAS/GAL4 system. To assess AKH general physiological rules, we ablated AKH endocrine cells by specifically driving the expression of apoptosis transgenes in AKH cells. Trehalose levels were decreased in larvae and starved adults, when the stimulation by AKH of the production of trehalose from fat body glycogen is no longer possible. Moreover, we show that these adults without AKH cells become progressively hypoactive. Finally, under starvation conditions, those hypoactive AKH-knockout cell flies survived ∼50% longer than control wild-type flies, suggesting that the slower rate at which AKH-ablated flies mobilize their energy resources extends their survival.
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Practical Statistics for Medical Research
Altman, D. G. (1990) · doi:10.1201/9780429258589 · Cited by 10,668
Cited by
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A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis
Bharucha, K. N., Tarr, P., & Zipursky, S. L. (2008) · Journal of Experimental Biology · doi:10.1242/jeb.016451 · Cited by 239
Inagaki, H. K., Panse, K. M., & Anderson, D. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.032 · Cited by 214
Energy Homeostasis Control in Drosophila Adipokinetic Hormone Mutants
Gáliková, M., Diesner, M., Klepsatel, P., Hehlert, P., Xu, Y., Bickmeyer, I., Predel, R., & Kühnlein, R. P. (2015) · Genetics · doi:10.1534/genetics.115.178897 · Cited by 206
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Metadata
- Authors
- Isabel, G., Martin, J.-R., Chidami, S., Veenstra, J. A., & Rosay, P.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2005-02
- Volume
- 288
- Issue
- 2
- Pages
- R531-R538
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2060869324
- Cited by
- 212
- References
- 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Isabel, G., Martin, J.-R., Chidami, S., Veenstra, J. A., & Rosay, P. (2005). AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.00158.2004
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