The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of mild carboxy-hemoglobin on exercising skeletal muscle: intravascular and intracellular evidence
Abstract
We studied muscle blood flow, muscle oxygen uptake (V˙o 2), net muscle CO uptake, Mb saturation, and intracellular bioenergetics during incremental single leg knee-extensor exercise in five healthy young subjects in conditions of normoxia, hypoxia (H; 11% O 2), normoxia + CO (CO norm), and 100% O 2+ CO (CO hyper). Maximum work rates and maximal oxygen uptake (V˙o 2 max) were equally reduced by ≈14% in H, CO norm, and CO hyper. The reduction in arterial oxygen content (Ca O 2 ) (≈20%) resulted in an elevated blood flow (Q) in the CO and H trials. Net muscle CO uptake was attenuated in the CO trials. Suprasystolic cuff measurements of the deoxy-Mb signal were not different in terms of the rate of signal rise or maximum signal attained with and without CO. At maximal exercise, calculated mean capillary Po 2 was most reduced in H and resulted in the lowest Mb-associated Po 2. Reductions in ATP, PCr, and pH during H, CO norm, and CO hyper occurred earlier during progressive exercise than in normoxia. Thus the effects of reduced Ca O 2 due to mild CO poisoning are similar to H.
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“Therefore, given that non‐invasive estimates of skeletal muscle oxidative capacity showed no effect from CO, we interpret CO as not having a direct or indirect (i.e., CO‐induced hypoxia) large impact on skeletal muscle of trained individuals as previously proposed by Richardson et al. (2002).”
From Effect of live‐high, train‐low strategy induced by chronic low‐dose carbon monoxide exposure on haematological parameters and performance in trained individuals (2026) · cites this paper as Richardson et al., 2002
In the citing paper
“Although CO mimics hypoxic conditions (Richardson et al., 2002), it does not elicit the hypoxia‐induced tachycardia or ventilatory response (Hanada et al., 2003), which probably contributed to the preservation of PV observed here.”
From Effect of live‐high, train‐low strategy induced by chronic low‐dose carbon monoxide exposure on haematological parameters and performance in trained individuals (2026) · cites this paper as Richardson et al., 2002
In the citing paper
“Emerging evidence (Schmidt et al., 2020; Urianstad et al., 2024) suggests that carbon monoxide (CO) inhalation mimics hypoxic conditions (Richardson et al., 2002) by reducing functional haemoglobin availability (Douglas et al., 1912; Haldane, 1912), while stimulating erythropoiesis (Montero & Lundby, 2019) without causing hypoxic‐induced tachycardia and hypoxic ventilatory response (Hanada et al.,”
From Effect of live‐high, train‐low strategy induced by chronic low‐dose carbon monoxide exposure on haematological parameters and performance in trained individuals (2026) · cites this paper as Richardson et al., 2002
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Cites
Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.
Richardson, R. S., Noyszewski, E. A., Kendrick, K. F., Leigh, J. S., & Wagner, P. D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118237 · Cited by 647
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Cited by
Principles, Techniques, and Limitations of Near Infrared Spectroscopy
Ferrari, M., Mottola, L., & Quaresima, V. (2004) · Canadian Journal of Applied Physiology · doi:10.1139/h04-031 · Cited by 997
Quaresima, V., Ferrari, M., Franceschini, M. A., Hoimes, M. L., & Fantini, S. (2004) · Journal of Biomedical Optics · doi:10.1117/1.1646417 · Cited by 45
Gatterer, H., Dünnwald, T., Woyke, S., Faulhaber, M., Schumacher, Y. O., & Schobersberger, W. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1490205 · Cited by 13
Villanova, S., Porcelli, S., Ekström, L., & Cardinale, D. A. (2026) · Experimental Physiology · doi:10.1113/ep093005 · Cited by 5
Metadata
- Authors
- Richardson, R. S., Noyszewski, E. A., Saltin, B., & González-Alonso, J.
- Affiliations
- Deparmement of Medicine University of California, San Diego, La Jolla, California 92093;
- Department of Radiology University of Pennsylvania, Philadelphia, Pennsylvania 19104; and
- Copenhagen Muscle Research Centre, Rigshopitalet, Copenhagen, Denmark
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2002-11-01
- Volume
- 283
- Issue
- 5
- Pages
- R1131-R1139
- ISSN
- 0363-6119
- 1522-1490
- Cited by
- 31
- References
- 1
- Language
- en
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