The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring
Abstract
Epidemiological and animal studies suggest that diet-induced epigenetic modifications in early life can contribute to development of the metabolic syndrome in adulthood. We previously reported features of the metabolic syndrome in adult offspring of rats fed a diet rich in animal fat during pregnancy and suckling. We now report a study to compare the relative effects of high-fat feeding during 1) pregnancy and 2) the suckling period in the development of these disorders. As observed previously, 6-mo-old female offspring of fat-fed dams suckled by the same fat-fed dams (OHF) demonstrated raised blood pressure, despite being fed a balanced diet from weaning. Female offspring of fat-fed dams “cross fostered” to dams consuming a control diet during suckling (OHF/C) demonstrated raised blood pressure compared with controls (OC) [systolic blood pressure (SBP; mmHg) means ± SE: OHF/C, 132.5 ± 3.0, n = 6 vs. OC, 119.0 ± 3.8, n = 7, P < 0.05]. Female offspring of controls cross fostered to dams consuming the fat diet (OC/HF) were also hypertensive [SBP (mmHg) 131.0 ± 2.5 mmHg, n = 6 vs. OC, P < 0.05]. Endothelium-dependent relaxation (EDR) of male and female OHF and OHF/C mesenteric small arteries was similar and blunted compared with OC ( P < 0.001). OC/HF arteries showed profoundly impaired EDR (OC/HF vs. OHF, P < 0.001). OHF/C and OC/HF demonstrated hyperinsulinemia and increased adiposity. Features of the metabolic syndrome in adult offspring of fat-fed rats can be acquired both antenatally and during suckling. However, exposure during pregnancy confers adaptive protection against endothelial dysfunction induced by maternal fat feeding during suckling.
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“a number of studies showed that maternal obesity induced greater adiposity and obesity [95,96,97,98] as well as hepatic steatosis [95,96,99] in the offspring.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [97]
Citations
Cites
Fetal programming and adult health
Godfrey, K. M., & Barker, D. J. P. (2001) · Public Health Nutrition · doi:10.1079/phn2001145 · Cited by 987
Kwong, W. Y., Wild, A. E., Roberts, P., Willis, A. C., & Fleming, T. P. (2000) · Development · doi:10.1242/dev.127.19.4195 · Cited by 798
Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview
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The developmental origins of the metabolic syndrome
Gluckman, P. D., & Hanson, M. A. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.03.002 · Cited by 638
Self-citationCatch-up growth and obesity in male mice
Ozanne, S. E., & Hales, C. N. (2004) · Nature · doi:10.1038/427411b · Cited by 554
Woodall, S., Johnston, B. M., Breier, B. H., & Gluckman, P. D. (1996) · Pediatric Research · doi:10.1203/00006450-199609000-00012 · Cited by 366
Gender-linked hypertension in offspring of lard-fed pregnant rats
Khan, I. Y., Taylor, P. D., Dekou, V., Seed, P. T., Lakasing, L., Graham, D., Dominiczak, A. F., Hanson, M. A., & Poston, L. (2003) · Hypertension · doi:10.1161/01.hyp.0000047511.97879.fc · Cited by 365
Self-citationOzaki, T., Nishina, H., Hanson, M. A., & Poston, L. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0141m.x · Cited by 321
Self-citationEarly programming of glucose-insulin metabolism.
Ozanne, S., & Hales, C. (2002) · Trends in endocrinology and metabolism · doi:10.1016/s1043-2760(02)00666-5 · Cited by 297
Taylor, P. D., McConnell, J., Khan, I. Y., Holemans, K., Lawrence, K. M., Asare-Anane, H., Persaud, S. J., Jones, P. M., Petrie, L., Hanson, M. A., et al. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00355.2004 · Cited by 297
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Samuelsson, A.-M., Matthews, P. A., Argenton, M., Christie, M. R., McConnell, J. M., Jansen, E. H. J. M., Piersma, A. H., Ozanne, S. E., Twinn, D. F., Remacle, C., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.101477 · Cited by 923
Self-citationEpigenetics: a molecular link between environmental factors and type 2 diabetes
Ling, C., & Groop, L. (2009) · Diabetes · doi:10.2337/db09-1003 · Cited by 617
Impact of maternal obesity on offspring obesity and cardiometabolic disease risk
Drake, A. J., & Reynolds, R. M. (2010) · Reproduction · doi:10.1530/rep-10-0077 · Cited by 507
Developmental programming of obesity in mammals
Taylor, P. D., & Poston, L. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2005.032854 · Cited by 473
Self-citationThe developmental origins of adult disease
Gluckman, P. D., Hanson, M. A., & Pinal, C. (2005) · Maternal & Child Nutrition · doi:10.1111/j.1740-8709.2005.00020.x · Cited by 473
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Metadata
- Authors
- Khan, I. Y., Dekou, V., Douglas, G., Jensen, R., Hanson, M. A., Poston, L., & Taylor, P. D.
- Affiliations
- King's College London (GB)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2005-01
- Volume
- 288
- Issue
- 1
- Pages
- R127-R133
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2121804122
- Cited by
- 357
- References
- 33
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 10 · 2018: 13 · 2017: 22 · 2016: 24 · 2015: 21 · 2014: 22 · 2013: 23 · 2012: 19
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- British Heart Foundation
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- high-fat diet, maternal diet, pregnancy, suckling, cardiovascular dysfunction, hypertension, metabolic syndrome, endothelial dysfunction, cross-fostering, hyperinsulinemia, adiposity, epigenetic programming, mesenteric small arteries
- MeSH terms
- Animals, Body Weight, Dietary Fats, Feeding Behavior, Female, Heart Rate, Hemodynamics, Lactation, Mesenteric Arteries, Pregnancy, Prenatal Exposure Delayed Effects, Vasodilation, Rats, Sprague-Dawley, Metabolic Syndrome, Maternal Nutritional Physiological Phenomena, Prenatal Nutritional Physiological Phenomena, Rats
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