Gender-linked hypertension in offspring of lard-fed pregnant rats
Abstract
Epidemiological studies suggest an association between maternal nutrition and offspring cardiovascular disease. We previously demonstrated endothelial dysfunction and abnormal aortic fatty acid composition in adult female offspring of rats fed animal lard during pregnancy. We have now further investigated this model. Female Sprague-Dawley rats were fed a control breeding diet (5.3% fat) or a diet rich in lard (25.7% fat) 10 days before and throughout pregnancy and lactation. Male and female offspring were implanted with radiotelemeters for recording of blood pressure, heart rate, and activity at 80, 180, and 360 days of age. Reactivity to acetylcholine and to nitric oxide were assessed in isolated small mesenteric arteries from 80- and 180-day-old littermates. Systolic blood pressure (awake phase) was raised in female offspring (180 days: offspring of control, 130.7±1.6 mm Hg, n=5, versus offspring of lard-fed, 138.1±2.9, n=5, P =0.029; 360 days: offspring of control, 129.7±3.7 mm Hg, n=6, versus offspring of lard-fed, 142.1±3.2, n=6, P =0.005). Diastolic blood pressure was also raised at 180 days (offspring of control, 87.6±1.0 mm Hg, n=5, versus offspring of lard-fed, 94.7±2.6, n=5, P =0.011). Blood pressure was not raised in male offspring. Endothelium-dependent relaxation to acetylcholine was blunted in male and female offspring of lard-fed dams (80 and 180 days). Feeding a diet rich in lard to pregnant rats leads to gender-related cardiovascular dysfunction in normally fed offspring.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several studies have reported hyperlipidemia in offspring of maternal obesity, including elevated free fatty acids, plasma triacylglycerol and reduced total and HDL cholesterol, though one study did not observe alterations in plasma lipids.
“Several of these studies have reported hyperlipidemia [96,100], including elevated free fatty acids, plasma triacylglycerol and reduced total and HDL cholesterol in the offspring, though one study did not observe alterations in plasma lipids [101].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [100]
Endothelium-dependent relaxation to acetylcholine was impaired in mesenteric arteries from 80- and 180-day-old female offspring of obese dams.
“Endothelium-dependent relaxation to acetylcholine was observed to be impaired in mesenteric arteries from 80- and 180-day-old female offspring of obese dams [100].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [100]
Several studies have reported impaired vascular function between three and six months of age in arteries isolated from rat offspring of obese dams.
“Several studies have reported elevated blood pressure as well as vascular remodeling and impaired vascular function between three and six months of age in arteries isolated from rat offspring of obese dams [94,100,126,127].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [100]
Several studies have reported vascular remodeling between three and six months of age in arteries isolated from rat offspring of obese dams.
“Several studies have reported elevated blood pressure as well as vascular remodeling and impaired vascular function between three and six months of age in arteries isolated from rat offspring of obese dams [94,100,126,127].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [100]
Several studies have reported elevated blood pressure between three and six months of age in arteries isolated from rat offspring of obese dams.
“Several studies have reported elevated blood pressure as well as vascular remodeling and impaired vascular function between three and six months of age in arteries isolated from rat offspring of obese dams [94,100,126,127].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [100]
Cites
Fetal nutrition and cardiovascular disease in adult life
Barker, D. J. P., Godfrey, K. M., Gluckman, P. D., Harding, J. E., Owens, J. A., & Robinson, J. S. (1993) · The Lancet · doi:10.1016/0140-6736(93)91224-a · Cited by 2,753 · see citing works
On the Variances of Asymptotically Normal Estimators from Complex Surveys
Binder, D. A. (1983) · International Statistical Review / Revue Internationale de Statistique · doi:10.2307/1402588 · Cited by 982 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910 · see citing works
Developmental programming of obesity in mammals
Taylor, P. D., & Poston, L. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2005.032854 · Cited by 473 · see citing works
Self-citationAnzman, S. L., Rollins, B. Y., & Birch, L. L. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.43 · Cited by 369 · see citing works
Khan, I. Y., Dekou, V., Douglas, G., Jensen, R., Hanson, M. A., Poston, L., & Taylor, P. D. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00354.2004 · Cited by 357 · see citing works
Self-citationMechanisms involved in the developmental programming of adulthood disease
Warner, M. J., & Ozanne, S. E. (2010) · Biochemical Journal · doi:10.1042/bj20091861 · Cited by 316 · see citing works
Taylor, P. D., McConnell, J., Khan, I. Y., Holemans, K., Lawrence, K. M., Asare-Anane, H., Persaud, S. J., Jones, P. M., Petrie, L., Hanson, M. A., et al. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00355.2004 · Cited by 297 · see citing works
Self-citationMechanisms of disease: the developmental origins of disease and the role of the epigenotype
Ozanne, S. E., & Constância, M. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0531 · Cited by 232 · see citing works
Bellinger, L., Sculley, D. V., & Langley-Evans, S. C. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803205 · Cited by 183 · see citing works
Early-Life Origins of Type 2 Diabetes: Fetal Programming of the Beta-Cell Mass
Portha, B., Chavey, A., & Movassat, J. (2011) · Experimental Diabetes Research · doi:10.1155/2011/105076 · Cited by 127 · see citing works
Fetal origins of the metabolic syndrome
Xita, N., & Tsatsoulis, A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05658.x · Cited by 96 · see citing works
Turdi, S., Ge, W., Hu, N., Bradley, K. M., Wang, X., & Ren, J. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.12.007 · Cited by 88 · see citing works
Ding, Y., Li, J., Liu, S., Zhang, L., Xiao, H., Li, J., Chen, H., Petersen, R. B., Huang, K., & Zheng, L. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.98 · Cited by 76 · see citing works
Kereliuk, S. M., & Dolinsky, V. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084467 · Cited by 34 · see citing works
Perinatal Exposure to Western Diet Programs Autonomic Dysfunction in the Male Offspring
Mukerjee, S., Zhu, Y., Zsombok, A., Mauvais-Jarvis, F., Zhao, J., & Lazartigues, E. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0502-4 · Cited by 18 · see citing works
- Authors
- Khan, I. Y., Taylor, P. D., Dekou, V., Seed, P. T., Lakasing, L., Graham, D., Dominiczak, A. F., Hanson, M. A., & Poston, L.
- Affiliations
- St Thomas' Hospital (GB)
- ORCID
- Venue
- Hypertension
- Published
- 2003-01
- Volume
- 41
- Issue
- 1
- Pages
- 168-175
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2118705787
- Cited by
- 365
- References
- 2
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 15 · 2021: 5 · 2020: 13 · 2019: 8 · 2018: 21 · 2017: 19 · 2016: 12 · 2015: 15 · 2014: 19 · 2013: 20 · 2012: 14
- FWCI
- 22.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- British Heart Foundation
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- maternal nutrition, lard, pregnancy, offspring hypertension, sex differences, endothelial dysfunction, acetylcholine, nitric oxide, mesenteric arteries, cardiovascular disease, blood pressure, lactation
- MeSH terms
- Animals, Blood Pressure, Body Weight, Dietary Fats, Eating, Endothelium, Vascular, Female, Heart Rate, Hypertension, Lipids, Male, Mesenteric Arteries, Myography, Pregnancy, Sex Factors, Telemetry, Vasodilation, Rats, Sprague-Dawley, Maternal Nutritional Physiological Phenomena, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
