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Cholecystokinin and gastric distension activate oxytocinergic cells in rat hypothalamus
Abstract
Systemic administration of cholecystokinin octapeptide (CCK-8) prompts an abrupt increase in circulating levels of oxytocin (OXY) but not vasopressin (VP) in rats. The present study determined whether CCK-8 selectively stimulated OXY-secreting neurons in the hypothalamic supraoptic nucleus of pentobarbital-anesthetized male rats. Antidromically identified neurosecretory neurons were categorized into putative OXY- and VP-secreting cells on the basis of their firing patterns and response to peripheral baroreceptor activation. Of 36 OXY-secreting cells studied, 30 demonstrated a 50-200% increase in firing frequency within 2 min of administering CCK-8 by intravenous or intraperitoneal injection, whereas none of the eight VP-secreting neurons studied was activated. In related experiments, 4-10 ml of air were used to inflate an intragastric balloon in rats; 20 of 22 OXY-secreting neurons displayed an abrupt and readily reversible increase in firing frequency, whereas only 2 of 17 VP-secreting cells were activated. Gastric distension similarly elevated plasma OXY levels in unanesthetized rats with indwelling gastric cannulas. Together with previous findings that the effects of CCK-8 on OXY release were attenuated by gastric vagotomy, these observations clearly demonstrate the existence of a sensitive neural link between the stomach and the neurohypophysis in the rat.
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Citations
Cited by
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Eliava, M., Melchior, M., Knobloch-Bollmann, H. S., Wahis, J., da Silva Gouveia, M., Tang, Y., Ciobanu, A. C., Triana del Rio, R., Roth, L. C., Althammer, F., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.041 · Cited by 409
Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System
Burbach, J. P. H., Luckman, S. M., Murphy, D., & Gainer, H. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1197 · Cited by 340
Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats
Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90176-p · Cited by 283
Self-citationMalcher-Lopes, R., Di, S., Marcheselli, V. S., Weng, F.-J., Stuart, C. T., Bazan, N. G., & Tasker, J. G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5126-05.2006 · Cited by 273
Metadata
- Authors
- Renaud, L. P., Tang, M., McCann, M. J., Stricker, E. M., & Verbalis, J. G.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1987-10-01
- Volume
- 253
- Issue
- 4
- Pages
- R661-R665
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2174305220
- Cited by
- 189
- References
- 0
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Renaud, L. P., Tang, M., McCann, M. J., Stricker, E. M., & Verbalis, J. G. (1987). Cholecystokinin and gastric distension activate oxytocinergic cells in rat hypothalamus. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1987.253.4.r661
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