Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats
Abstract
Intracerebroventricular administration of oxytocin (OT) and an OT agonist significantly decreased food intake in a dose-related manner in fasted rats. Central administration of an OT antagonist by itself (up to doses of 8 nmol) did not potentiate deprivation-induced food intake, but pretreatment with the OT receptor antagonist prevented the expected inhibition of food intake produced by OT and the OT agonist. Once-daily ICV injections of OT led to the development of tolerance to the inhibitory effects on food intake by the third day of treatment, but daily pretreatment with the OT antagonist prevented the development of this tolerance. In addition to causing decreased food intake, ICV administration of OT significantly increased grooming behavior but produced no dyskinesias. The inhibitory effect of OT on food intake was characterized by decreased amounts of food intake but a normal pattern of ingestion. The anorexia produced was central in nature and was not associated with altered plasma levels of hormones involved in caloric homeostasis or with changes in blood glucose. The OT agonist had relatively little effect on water intake when given in doses that significantly inhibited food intake. These results support the hypothesis that specific OT receptors within the central nervous system participate in the inhibition of feeding under certain conditions in rats.
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In rodent studies, oxytocin acts as a strong inhibitor of food intake.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [8]
Preclinical studies indicate that oxytocin is anorexigenic and has beneficial metabolic effects.
“Preclinical studies indicate that oxytocin is anorexigenic and has beneficial metabolic effects.”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [5]
In animal models, administration of oxytocin to rats reduces caloric intake, and this effect is reversed by first giving an oxytocin antagonist.
“Administration of oxytocin to rats reduces caloric intake, and this effect is reversed by first giving an oxytocin antagonist(4, 5).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [5]
In rodent studies, oxytocin affects glucose homeostasis.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [8]
Oxytocin reduces food intake in normal-weight rodents and in animals with diet-induced obesity.
“Importantly, oxytocin reduces food intake not only in normal-weight rodents but also in animals with diet-induced obesity (8,12,13)”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [8]
In rodent studies, oxytocin affects energy expenditure.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [8]
Oxytocin inhibits feeding after intracerebroventricular injection in rodents.
“Oxytocin has been shown in a number of experiments in rodents to inhibit feeding after intracerebroventricular injection (6,8).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [8]
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- Authors
- Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G.
- Affiliations
- University of Pittsburgh (US)
- University of Arizona (US)
- Corresponding author
- Olson, Beatriz R.
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 1991-01
- Volume
- 12
- Issue
- 1
- Pages
- 113-118
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2084234221
- Cited by
- 283
- References
- 32
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 15 · 2020: 8 · 2019: 15 · 2018: 15 · 2017: 16 · 2016: 17 · 2015: 20 · 2014: 9 · 2013: 14 · 2012: 12
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh
- National Institute for Health and Care Research
- National Institutes of Health
- National Institute of Mental Health (MH25140)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK17420, R01DK017420)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, dietary intake, anorexia, intracerebroventricular administration, tolerance (pharmacology and immunology), grooming, water intake, feeding inhibition
- MeSH terms
- Animals, Blood Glucose, Drinking, Eating, Glucagon, Injections, Intraventricular, Insulin, Male, Oxytocin, Rats, Inbred Strains, Receptors, Oxytocin, Rats, Angiotensin Receptor Antagonists
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