Spinoreticular cell responses to renal venous and ureteral occlusion
Abstract
Responses of 65 thoracolumbar spinoreticular neurons to renal vein or ureteral occlusion were studied in 40 alpha-chloralose-anesthetized cats. Cells were antidromically activated from the medial medullary reticular formation and all responded to somatic stimuli as well as renal nerve stimulation. Renal vein occlusion excited 17 of 40 cells. Activity increased from 6 +/- 1 to 13 +/- 2 spikes/s, with little adaptation. Depressor responses occurred in 9 cats and pressor responses in 12 cats. Pressor responses, but not depressor responses, were abolished by renal denervation. Ureteral occlusion increased activity of 28 of 50 cells. Responses were always rapid in onset but were either nonadapting, slowly adapting, or completely adapting. Activity increased from 7 +/- 1 to a peak of 17 +/- 3 spikes/s. Pressor responses occurred in 22 of 25 cats and tachycardia in 15 cats. Transection of renal nerves abolished cardiovascular responses. Twenty-five cells were tested for responses for both stimuli. Ten were excited by both, six by only ureteral occlusion, and nine failed to respond to either. The responding group of cells had a significantly greater incidence of A delta- and C-fiber renal input compared with nonresponding cells. Nonresponding cells tended to have only A delta-input. The results show that renal and ureteral mechanical stimuli which evoke cardiovascular reflexes excite spinoreticular cells. These cells may be part of supraspinal reflex arcs initiated by renal receptors…
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Increased pelvic pressure raises afferent renal nerve activity.
“One such stimulus is increased pelvic pressure, which results in increased afferent renal nerve activity46–48.”
From Renal nerves in physiology, pathophysiology and interoception (2025) · cites this paper as [46]
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Role of the Renal Nerves in Hypertension
Foss, J. D. (2014) · University of Minnesota Digital Conservancy (University of Minnesota)
- Authors
- Ammons, W. S.
- Affiliations
- Thomas Jefferson University (US)
- Corresponding author
- Ammons, W. S.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1988-02-01
- Volume
- 254
- Issue
- 2
- Pages
- R268-R276
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2257587994
- Cited by
- 19
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2017: 2 · 2014: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-36378, HL-30985)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- renal vein occlusion, ureteral occlusion, renal nerve stimulation, pressor response, depressor response, tachycardia, renal denervation, A-delta fibers, C-fibers, cardiovascular reflexes, antidromic activation
- MeSH terms
- Afferent Pathways, Animals, Blood Pressure, Cardiovascular Physiological Phenomena, Cats, Electrophysiology, Evoked Potentials, Kidney, Mechanoreceptors, Reflex, Renal Veins, Reticular Formation, Spinal Cord, Ureter
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