Differentiated norepinephrine spillover in human skeletal muscle
Abstract
Most neurophysiological studies have shown similar sympathetic outflow to arm and leg. However, some direct microneurographic recordings indicate differentiated sympathetic outflow to limbs both at rest and during mental stress. Hence, differentiated levels of norepinephrine (NE) spillover could prevail. By steady-state infusion of [3H]NE and body composition determination by dual-energy X-ray absorptiometry-scan, we simultaneously assessed arm and leg NE spillover related to 100 g tissue and total limb weight. NE spillover was lower in leg than arm (0.26 vs. 1.51 pmol.min-1.100 g-1, P < 0.05), and the difference remained when expressed as a function of total limb weight (66 vs. 137 pmol/min, P < 0.05). Fractional extraction of [3H]NE was similar in arm and leg. Neuronal uptake blockade by desipramine was more effective in leg than arm; fractional extraction in leg decreased by 32% (P < 0.05) but was unaltered in arm. Thus a lower NE spillover was observed from leg than arm, possibly reflecting a lower sympathetic outflow and a more neuronally dependent reuptake.
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Noradrenaline spillover to plasma from skeletal muscle is regionalised, with noradrenaline spillover in the legs being substantially less than that of the arms even after correcting for limb mass.
“Given that noradrenaline spillover to plasma from skeletal muscle is regionalised, with noradrenaline spillover in the legs being substantially less than that of the arms even after correcting for limb mass (Karlsson et al. 1997), the '20% skeletal muscle contribution to whole body' is most probably an over-estimate.”
From Single‐unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover (2011) · cites this paper as Karlsson et al. 1997
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“At rest, vascular resistance is reportedly greater in the legs than in the arms (13), despite regional norepinephrine spillover being greater in the arms than in the legs (13, 19).”
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“Although the amplitude of activation of SNA is similar between arm and leg muscle, norepinephrine spillover differs between limbs (Jacob et al. 2000; Karlsson et al. 1997) because norepinephrine spillover is related to differences in adrenergic responsiveness -80 -60 -40 -20 0 20 40”
Background
- Authors
- Karlsson, A. K., Elam, M., Lonnroth, P., Sullivan, L., & Friberg, P.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Department of Neurology, Sahlgrenska University Hospital, Goteborg,Sweden.
- ORCID
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1997-07-01
- Volume
- 273
- Issue
- 1
- Pages
- R16-R21
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2285325461
- Cited by
- 14
- References
- 0
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- norepinephrine spillover, skeletal muscle, sympathetic activity, norepinephrine uptake, desipramine, fractional extraction, body composition, psychological stress
- MeSH terms
- Adult, Arm, Body Composition, Desipramine, Female, Hemodynamics, Humans, Infusions, Intravenous, Leg, Male, Neurons, Norepinephrine, Regional Blood Flow, Skin Temperature, Tritium, Vascular Resistance, Absorptiometry, Photon, Confidence Intervals, Muscle, Skeletal
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