The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo
Abstract
The effect of in vivo infusion of the peptide hormone glucagon-like peptide 2 (GLP-2) on glucose transport across the rat jejunal brush-border membrane (BBM) was assessed using isolated membrane vesicles. A 2-h infusion of GLP-2 produced a marked acceleration of sodium-dependent glucose uptake into BBM vesicles with a significant overshoot. There was no change in vesicle space or permeability resulting from the hormone infusion. Kinetic analysis showed this stimulation to be the result of a threefold increase in the maximal rate of transport, with no consistent change in the affinity constant ( K m). The time course of this response showed that the effect was observable, but smaller, after only 30 min of hormone infusion and was maximal after 1 h. Sodium-dependent phloridzin binding to the membrane vesicles showed a parallel increase in maximal binding after 1 and 2 h of hormone infusion. Western blotting showed a similar increase in sodium-dependent glucose transporter 1 (SGLT-1) abundance. The effect of GLP-2 could be blocked by luminal brefeldin A or wortmannin. These results indicate that GLP-2 is able to induce trafficking of SGLT-1 from an intracellular pool into the BBM within 60 min and that phosphoinositol 3-kinase may well be involved in the intracellular signaling pathway in this response.
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In the citing paper
“This is also true for GLP-2 release, which is STR-dependent in rodents (28,29) and inhibited by the murine STR inhibitor, gurmarin (30).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [29]
In the citing paper
“Jugular vein infusion of GLP-2 increases the abundance of SGLT-1 protein and rate of SGLT-1-dependent glucose transport in the apical membrane of jejunal enterocytes in rats, a response abolished when protein translocation is inhibited with brefeldin (29,59).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [29]
Citations
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Kieffer, T. J., & Habener, J. F. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.6.0385 · Cited by 1,062
Biological actions and therapeutic potential of the glucagon-like peptides
Drucker, D. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.31068 · Cited by 509
Sugar Absorption in the Intestine: The Role of GLUT2
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Jeppesen, P. B. (2005) · Gut · doi:10.1136/gut.2004.061440 · Cited by 467
Metadata
- Authors
- Cheeseman, C. I.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Cheeseman, C. I.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1997-12-01
- Volume
- 273
- Issue
- 6
- Pages
- R1965-R1971
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2174791196
- Cited by
- 267
- References
- 30
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 6 · 2014: 17 · 2013: 9 · 2012: 11
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- glucagon-like peptide-2, SGLT1, glucose transport, intestinal glucose absorption, phosphoinositide 3-kinase signaling, brefeldin A, wortmannin
- MeSH terms
- Wortmannin, Androstadienes, Animals, Cyclopentanes, Glucagon-Like Peptides, Gastrointestinal Hormones, Glucose, Infusions, Intravenous, Intestinal Mucosa, Jejunum, Kinetics, Membrane Glycoproteins, Microvilli, Monosaccharide Transport Proteins, Peptides, Phlorhizin, Sodium, Brefeldin A, Sodium-Glucose Transporter 1, Rats, Glucagon-Like Peptide 2
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