The DOI matches its Crossref record, with a small difference in title or year; 21 of the 21 references it cites were found in a registry or an index.
Cytokine-induced fever in obese (fa/fa) and lean (Fa/Fa) Zucker rats
Abstract
In earlier work, we reported that genetically obese ( fa/ fa) Zucker rats exhibited significantly greater anorexia than did lean ( Fa/ Fa) Zucker rats to intracerebroventricular infusion of interleukin (IL)-1β. Here, we investigated the fever response of obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats to intracerebroventricular microinfusion of IL-1β as well as to the following other cytokines: IL-2, IL-6, and tumor necrosis factor-α (TNF-α). Core body temperature was monitored by a radiotelemetry system in freely moving rats. The results show that 1) both IL-1β and IL-6 induce fevers in obese and lean rats; 2) IL-1β induces a significantly higher fever response in obese rats than it does in lean rats; 3) IL-6 induces a significantly higher fever response in lean rats than it does in obese rats; 4) IL-2 induces a moderate fever response in lean but not obese rats; 5) TNF-α induces a similar fever response in obese and lean rats; and 6) the fevers induced by each effective cytokine have different time courses. Thus obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats show differential responsiveness to the intracerebroventricular microinfusion of various classes of cytokines. This suggests that genetic obesity in the fa/fa Zucker rat is associated with differential cytokine action on thermoregulatory mechanisms.
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Despite large increases in IL-6 in susceptible mice, they do not demonstrate changes in core body temperature that can transiently affect motivated behavior.
“Despite large increases in IL-6 in susceptible mice, they do not demonstrate changes in core body temperature that can transiently affect motivated behavior (30).”
From Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress (2014) · cites this paper as [30]
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SHORT COMMUNICATION Does obesity affect febrile responsiveness?
Ivanov, A., Kulchitsky, V. A., & Romanovsky, A. A. (2016)
Metadata
- Authors
- Plata-Salamán, C. R., Peloso, E., & Satinoff, E.
- Affiliations
- Departments ofBiological Sciences and
- Psychology and
- University of Delaware (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1998-10-01
- Volume
- 275
- Issue
- 4
- Pages
- R1353-R1357
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2117306739
- Cited by
- 19
- References
- 21
- Citations by year
- 2016: 3 · 2014: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh056082-02, 5r01mh041138-16)
- National Institute of Mental Health (R01-MH56082, R01 MH 41138)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- genetic obesity, Zucker fatty rats, IL-1β, interleukin-6, interleukin-2, TNF-α, thermoregulation, core body temperature, anorexia
- MeSH terms
- Animals, Body Temperature, Body Temperature Regulation, Cerebral Ventricles, Fever, Infusions, Parenteral, Interleukin-1, Interleukin-2, Male, Obesity, Rats, Zucker, Thinness, Time Factors, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Rats
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