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Cited by 14Ion Transport and Channel RegulationParathyroid Disorders and TreatmentsRenal function and acid-base balance

Coupling of renal sodium and calcium transport: a modeling analysis of transporter inhibition and sex differences

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Hakimi, Shervin, Dutta, Pritha, Layton, Anita T.·2023·American Journal of Physiology-Renal Physiology
DOI 10.1152/ajprenal.00145.2023
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Abstract

The kidney plays an important role in the maintenance of whole body Ca 2+ balance by regulating Ca 2+ reabsorption and excretion. This computational modeling study provides insights into how Ca 2+ transport along the nephron is coupled to Na+. Model results indicated that along the proximal tubule and thick ascending limb, Ca 2+ and Na+ transport occur in parallel, but those processes were dissociated in the distal convoluted tubule. Simulations also revealed sex-specific responses to different pharmacological manipulations.

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Crossref · 10.1152/ajprenal.00145.2023

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Authors
Hakimi, S., Dutta, P., & Layton, A. T.
Affiliations
University of Waterloo (CA)
Corresponding author
Layton, Anita T.
ORCID
Venue
American Journal of Physiology-Renal Physiology
Publisher
American Physiological Society
Published
2023-11-01
Volume
325
Issue
5
Pages
F536-F551
ISSN
  • 1522-1466 (ISSN-L)
  • 1931-857X
DOI
10.1152/ajprenal.00145.2023
OpenAlex
W4386117339
Cited by
14
References
3
Citations by year
2026: 4 · 2025: 2 · 2024: 7 · 2023: 1
FWCI
1.24
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • American Journal of Physiology-Renal Physiology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Nephrology › Renal function and acid-base balance
Keywords
renal calcium transport, sodium transport, calcium reabsorption, proximal tubule, thick ascending limb, distal convoluted tubule, nephron, transporter inhibition, sex differences, calcium balance, pharmacological manipulation
MeSH terms
Animals, Calcium, Diuretics, Female, Kidney Tubules, Distal, Male, Sex Characteristics, Sodium, Membrane Transport Proteins, Rats

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