Sex steroids and the kidney: role in renal calcium and phosphate handling
Abstract
Calcium and phosphate are vital for the organism and constitute essential components of the skeleton. Serum levels are tightly hormonally regulated and maintained by exchange with three major sources: the intestines, the kidney and the bone. The effects of sex steroids on the bone have been extensively studied and it is well known that sex steroid deficiency induces bone loss, indirectly influencing renal calcium and phosphate homeostasis. However, it is unknown whether sex steroids also directly regulate renal calcium and phosphate handling, hereby potentially indirectly impacting on bone. The presence of androgen receptors (AR) and estrogen receptors (ER) in both human and rodent kidney, although their exact localization within the kidney remains debated, supports direct effects. Estrogens stimulate renal calcium reabsorption as well as phosphate excretion, while the effects of androgens are less clear. Many of the studies performed with regard to renal calcium and/or phosphate homeostasis do not correct for the calcium and phosphate fluxes from the bone and intestines, which complicates the differentiation between the direct effects of sex steroids on renal calcium and phosphate handling and the indirect effects via the bone and intestines. The objective of this study is to review the literature and current insight of the role of sex steroids in calcium and phosphate handling in the kidney.
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Sex differences have been found in the RAS and renal handling of calcium.
“However, sex differences have been found in the RAS [60] and renal handling of calcium [61,62].”
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- Authors
- Khalil, R., Kim, N. R., Jardi, F., Vanderschueren, D., Claessens, F., & Decallonne, B.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Khalil, Rougin
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 465
- Pages
- 61-72
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2769148359
- Cited by
- 53
- References
- 108
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 7 · 2023: 12 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 3
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Funders
- KU Leuven (GOA/15/017)
- Research Foundation Flanders (FWO) (G0D2217N)
- FWO (G0D2217N)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- sex steroids, renal calcium handling, renal phosphate handling, calcium homeostasis, phosphate homeostasis, androgen receptor, estrogen receptor, kidney, bone, sex hormone deficiency, bone loss, calcium reabsorption, phosphate excretion
- MeSH terms
- Animals, Calcium, Humans, Kidney, Models, Biological, Phosphates, Gonadal Steroid Hormones
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