The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages
Abstract
The role of monocytes/macrophages in the pathogenesis of ischemia-reperfusion injury (IRI) is unknown. We sought to determine whether activation of macrophage adenosine 2A (A 2A) receptors (A 2A Rs) mediates tissue protection. We subjected C57Bl/6 mice infused with clodronate [dichloromethylene bisphosphonate (Cl 2 MBP)] to IRI (32 min of ischemia followed by 24 h of reperfusion) to deplete them of macrophages. IRI induced an elevation of plasma creatinine that was reduced with Cl 2 MBP (26% of control). Adoptive transfer of murine RAW 264.7 cells reconstituted injury, an effect blocked significantly by A 2A agonists (27% of plasma creatinine from mice reconstituted with macrophages). Macrophages subjected to A 2A knockout by small interfering RNA were adoptively transferred to macrophage-depleted mice and reconstituted injury (110% of control mice); however, the increase in plasma creatinine was blocked by A 2A agonists (20% of vehicle treatment). Finally, the A 2A agonist effect on IRI was blocked in macrophage-depleted A 2A-knockout mice reconstituted with wild-type RAW 264.7 cells. RNase protection assays 24 h after IRI demonstrated that macrophages are required for IL-6 and TGF-β mRNA induction. However, A 2A agonist-mediated tissue protection is independent of IL-6 and TGF-β mRNA. We conclude that the full extent of IRI requires macrophages and that A 2A agonist-mediated tissue protection is independent of activation of macrophage A 2A Rs.
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Cited by
Update on Mechanisms of Ischemic Acute Kidney Injury
Devarajan, P. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006010017 · Cited by 1,026
Distinct macrophage phenotypes contribute to kidney injury and repair
Lee, S., Huen, S., Nishio, H., Nishio, S., Lee, H. K., Choi, B.-S., Ruhrberg, C., & Cantley, L. G. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060615 · Cited by 906
Hepatic platelet and leukocyte adherence during endotoxemia
Croner, R. S., Hoerer, E., Kulu, Y., Hackert, T., Gebhard, M.-M., Herfarth, C., & Klar, E. (2006) · Critical Care · doi:10.1186/cc3968 · Cited by 275
Immune cells and inflammation in AKI to CKD progression
Sato, Y., & Yanagita, M. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00195.2018 · Cited by 273
Rapamycin-inspired macrocycles with new target specificity
Guo, Z., Hong, S. Y., Wang, J., Rehan, S., Liu, W., Peng, H., Das, M., Li, W., Bhat, S., Peiffer, B., et al. (2019) · Nature Chemistry · doi:10.1038/s41557-018-0187-4 · Cited by 120
Metadata
- Authors
- Day, Y.-J., Huang, L., Ye, H., Linden, J., & Okusa, M. D.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2005-04
- Volume
- 288
- Issue
- 4
- Pages
- F722-F731
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2141781896
- Cited by
- 331
- References
- 36
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Day, Y.-J., Huang, L., Ye, H., Linden, J., & Okusa, M. D. (2005). Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.00378.2004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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