Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK autophagy
Abstract
Fenofibrate activates not only peroxisome proliferator-activated receptor-α (PPARα) but also adenosine monophosphate-activated protein kinase (AMPK). AMPK-mediated cellular responses protect kidney from high-fat diet (HFD)-induced injury, and autophagy resulting from AMPK activation has been regarded as a stress-response mechanism. Thus the present study examined the role of AMPK and autophagy in the renotherapeutic effects of fenofibrate. C57BL/6J mice were divided into three groups: normal diet (ND), HFD, and HFD + fenofibrate (HFD + FF). Fenofibrate was administered 4 wk after the initiation of the HFD when renal injury was initiated. Mouse proximal tubule cells (mProx24) were used to clarify the role of AMPK. Feeding mice with HFD for 12 wk induced insulin resistance and kidney injury such as albuminuria, glomerulosclerosis, tubular injury, and inflammation, which were effectively inhibited by fenofibrate. In addition, fenofibrate treatment resulted in the activation of renal AMPK, upregulation of fatty acid oxidation (FAO) enzymes and antioxidants, and induction of autophagy in the HFD mice. In mProx24 cells, fenofibrate activated AMPK in a concentration-dependent manner, upregulated FAO enzymes and antioxidants, and induced autophagy, all of which were inhibited by treatment of compound C, an AMPK inhibitor. Fenofibrate-induced autophagy was also significantly blocked by AMPKα1 siRNA but not by PPARα siRNA. Collectively, these results demonstrate that delayed treatment with fenofibrate has a therapeutic effect on HFD-induced kidney injury, at least in part, through the activation of AMPK and induction of subsequent downstream effectors: autophagy, FAO enzymes, and antioxidants.
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600 · see citing works
Autophagy: from phenomenology to molecular understanding in less than a decade
Klionsky, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2245 · Cited by 1,933 · see citing works
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Finck, B. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27794 · Cited by 1,427 · see citing works
Obesity-related glomerulopathy: An emerging epidemic
Kambham, N., Markowitz, G. S., Valeri, A. M., Lin, J., & D’Agati, V. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590041498.x · Cited by 1,279 · see citing works
Heras-Sandoval, D., Pérez-Rojas, J. M., Hernández-Damián, J., & Pedraza-Chaverri, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.08.019 · Cited by 1,091 · see citing works
Metabolic Syndrome and Kidney Disease: A Systematic Review and Meta-analysis
Thomas, G., Sehgal, A. R., Kashyap, S. R., Srinivas, T. R., Kirwan, J. P., & Navaneethan, S. D. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02180311 · Cited by 553 · see citing works
AMPK: positive and negative regulation, and its role in whole-body energy homeostasis
Hardie, D. G. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.09.004 · Cited by 485 · see citing works
Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury
Kimura, T., Takabatake, Y., Takahashi, A., Kaimori, J.-Y., Matsui, I., Namba, T., Kitamura, H., Niimura, F., Matsusaka, T., Soga, T., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010070705 · Cited by 461 · see citing works
Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease
Ix, J. H., & Sharma, K. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009080820 · Cited by 351 · see citing works
Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells
Periyasamy‐Thandavan, S., Jiang, M., Wei, Q., Smith, R., Yin, X., & Dong, Z. (2008) · Kidney International · doi:10.1038/ki.2008.214 · Cited by 319 · see citing works
Fructokinase activity mediates dehydration-induced renal injury
Jimenez, C. A. R., Ishimoto, T., Lanaspa, M. A., Rivard, C. J., Nakagawa, T., Ejaz, A. A., Cicerchi, C., Inaba, S., Le, M. T., Miyazaki, M., et al. (2013) · Kidney International · doi:10.1038/ki.2013.492 · Cited by 271 · see citing works
The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease
Odermatt, A. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00068.2011 · Cited by 255 · see citing works
AMPK Mediates the Initiation of Kidney Disease Induced by a High-Fat Diet
Declèves, A., Mathew, A. V., Cunard, R. A., & Sharma, K. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011010026 · Cited by 250 · see citing works
Wu, Y., Tan, H., Huang, Q. B., Ong, C. N., & Shen, H. (2009) · Autophagy · doi:10.4161/auto.9099 · Cited by 241 · see citing works
Renal injury in the extremely obese patients with normal renal function
Serra, A., Romero, R., López, D., Navarro-Díaz, M., Esteve, A., Pérez‐Álvarez, N., Alastrue, A., & Ariza, A. (2008) · Kidney International · doi:10.1038/sj.ki.5002796 · Cited by 236 · see citing works
Regulation of lipid accumulation by AMK-activated kinase in high fat diet–induced kidney injury
Declèves, A., Zolkipli‐Cunningham, Z., Satriano, J. A., Wang, L., Nakayama, T., Rogač, M., Le, T. P., Nortier, J., Farquhar, M. G., Naviaux, R. K., et al. (2013) · Kidney International · doi:10.1038/ki.2013.462 · Cited by 232 · see citing works
Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions
Yamahara, K., Kume, S., Koya, D., Tanaka, Y., Morita, Y., Chin-Kanasaki, M., Araki, H., Isshiki, K., Araki, S.-I., Haneda, M., et al. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012111080 · Cited by 213 · see citing works
Zhai, C., Cheng, J., Mujahid, H., Wang, H., Kong, J., Yin, Y., Li, J., Zhang, Y. L., Ji, X., & Chen, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090563 · Cited by 194 · see citing works
Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis
Tanaka, Y., Kume, S., Araki, S., Isshiki, K., Chin‒Kanasaki, M., Sakaguchi, M., Sugimoto, T., Koya, D., Haneda, M., Kashiwagi, A., et al. (2011) · Kidney International · doi:10.1038/ki.2010.530 · Cited by 190 · see citing works
Catalase Deficiency Accelerates Diabetic Renal Injury Through Peroxisomal Dysfunction
Hwang, I., Lee, J., Huh, J. Y., Park, J., Lee, H. B., Ho, Y.-S., & Ha, H. (2012) · Diabetes · doi:10.2337/db11-0584 · Cited by 173 · see citing works
Self-citationMegalin-Mediated Tubuloglomerular Alterations in High-Fat Diet–Induced Kidney Disease
Kuwahara, S., Hosojima, M., Kaneko, R., Aoki, H., Nakano, D., Sasagawa, T., Kabasawa, H., Kaseda, R., Yasukawa, R., Ishikawa, T., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015020190 · Cited by 125 · see citing works
Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
Hong, Y. A., Lim, J. H., Kim, M. Y., Kim, T. W., Kim, Y., Yang, K. S., Park, H. S., Choi, S. R., Chung, S., Kim, H. W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096147 · Cited by 118 · see citing works
Self-citationFenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway
Kim, J., Ahn, J., Kim, J., Yu, Y.-S., Kim, H., Ha, J., Shinn, S.-H., & Oh, Y.-S. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.01.009 · Cited by 111 · see citing works
Self-citationDarwish, R., Amiridze, N. S., & Aarabi, B. (2007) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e318069178a · Cited by 103 · see citing works
Kitada, M., Ogura, Y., Suzuki, T., Sen, S., Lee, S. M., Kanasaki, K., Kume, S., & Koya, D. (2016) · Diabetologia · doi:10.1007/s00125-016-3925-4 · Cited by 97 · see citing works
Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression
van der Hoogt, C. C., de Haan, W., Westerterp, M., Hoekstra, M., Dallinga‐Thie, G. M., Romijn, J. A., Princen, H. M. G., Jukema, J. W., Havekes, L. M., & Rensen, P. C. N. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700108-jlr200 · Cited by 95 · see citing works
Okayasu, T., Tomizawa, A., Suzuki, K., Manaka, K., & Hattori, Y. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.02.002 · Cited by 91 · see citing works
Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity
Ma, L.-J., Corsa, B. A., Zhou, J., Yang, H., Li, H., Tang, Y., Babaev, V. R., Major, A. S., Linton, M. F., Fazio, S., et al. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00468.2010 · Cited by 91 · see citing works
Chung, H. W., Lim, J. H., Kim, M. Y., Shin, S. J., Chung, S., Choi, B. S., Kim, H. W., Kim, Y., Park, C. W., & Chang, Y. S. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr613 · Cited by 82 · see citing works
Self-citationFenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC
Murakami, H., Murakami, R., Kambe, F., Cao, X., Takahashi, R., Asai, T., Hirai, T., Numaguchi, Y., Okumura, K., Seo, H., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.052 · Cited by 81 · see citing works
Fenofibrate lowers lipid accumulation in myotubes by modulating the PPARα/AMPK/FoxO1/ATGL pathway
Chen, W.-L., Chen, Y., Chiang, Y.-M., Wang, S.-G., & Lee, H.-M. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.05.022 · Cited by 73 · see citing works
Tomizawa, A., Hattori, Y., Inoue, T., Hattori, S., & Kasai, K. (2010) · Metabolism · doi:10.1016/j.metabol.2010.04.020 · Cited by 69 · see citing works
Intrarenal renin-angiotensin system mediates fatty acid-induced ER stress in the kidney
Li, C., Lin, Y., Luo, R., Chen, S., Wang, F., Zheng, P., Levi, M., Yang, T., & Wang, W. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00223.2015 · Cited by 67 · see citing works
Palma, C. D., Perrotta, C., Pellegrino, P., Clementi, E., & Cervia, D. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00188 · Cited by 66 · see citing works
Chanda, D., Lee, C. H., Kim, Y.-H., Noh, J., Kim, D., Park, J.-H., Hwang, J. H., Lee, M., Jeong, K.-H., Lee, I., et al. (2009) · Hepatology · doi:10.1002/hep.23049 · Cited by 62 · see citing works
The Effect of Obesity on Chronic Kidney Disease
Kopple, J. D., & Feroze, U. (2011) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2010.10.009 · Cited by 61 · see citing works
Metabolic syndrome and chronic kidney disease
Ruan, X. Z., & Guan, Y. (2009) · Journal of Diabetes · doi:10.1111/j.1753-0407.2009.00042.x · Cited by 60 · see citing works
Balakumar, P., Kadian, S., & Mahadevan, N. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.01.004 · Cited by 54 · see citing works
Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance
Sun, Y., Qu, X., HOWARD, V. G., Dai, L., Jiang, X., Ren, Y., Fu, P., Puelles, V. G., Nikolic‐Paterson, D. J., Caruana, G., et al. (2015) · Kidney International · doi:10.1038/ki.2015.121 · Cited by 52 · see citing works
Sun, Y., Ren, M., Gao, G.-Q., Gong, B., Xin, W., Guo, H., Zhang, X., Gao, L., & Zhao, J. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00717.x · Cited by 42 · see citing works
Zeng, R., Xiong, Y., Zhu, F., Ma, Z., Liao, W., He, Y., He, J.-S., Li, W., Yang, J., Lü, Q., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076836 · Cited by 39 · see citing works
Liu, T., & José, P. A. (2012) · Endocrinology · doi:10.1210/en.2012-1813 · Cited by 34 · see citing works
Zhang, A., Uaesoontrachoon, K., Shaughnessy, C. J., Das, J. R., Rayavarapu, S., Brown, K. J., Ray, P. E., Nagaraju, K., van den Anker, J. N., Hoffman, E. P., et al. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2015.05.008 · Cited by 27 · see citing works
Ying, Y., Sun, ., Meng, M., Ren, R., Guan-qi, Gao, Bendi, Gong, M., Wei, Xin, et al. (2008) · 中国药理学报:英文版 · Cited by 25 · see citing works
Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice
Park, J. H., Chung, H. Y., Kim, M., Lee, J. H., Jung, M., & Ha, H. (2014) · Aging Cell · doi:10.1111/acel.12224 · Cited by 18 · see citing works
Self-citationShort-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice
Park, J. H., & Ha, H. (2015) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2015.19.3.269 · Cited by 10 · see citing works
Self-citationMurakami, R., Murakami, H., Kataoka, H., Cheng, X. W., Takahashi, R., Numaguchi, Y., Murohara, T., & Okumura, K. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.09.005 · Cited by 6 · see citing works
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Islam, M. N., Hossain, K. S., Sarker, S., Ferdous, J., Hannan, M. A., Rahman, M. M., Chu, D., & Uddin, M. J. (2020) · Phytotherapy Research · doi:10.1002/ptr.6895 · Cited by 83 · see citing works
Self-citationHannan, M. A., Rahman, M. A., Rahman, M. S., Sohag, A. A. M., Dash, R., Hossain, K. S., Farjana, M., & Uddin, M. J. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.07.001 · Cited by 74 · see citing works
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Self-citationMonteillet, L., Gjorgjieva, M., Silva, M., Verzieux, V., Imikirene, L., Duchampt, A., Guillou, H., Mithieux, G., & Rajas, F. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.07.006 · Cited by 64 · see citing works
Rahman, M. A., Saha, S. K., Rahman, M. S., Uddin, M. J., Uddin, M. S., Pang, M., Rhim, H., & Cho, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00283 · Cited by 63 · see citing works
Self-citationAnti-inflammatory role of fenofibrate in treating diseases
Jin, L., Hu, H., Ji, Y., Jia, Z., Peng, M., & Huang, S. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2022.8534 · Cited by 58 · see citing works
Luo, Y., Liu, L., & Zhang, C. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107780 · Cited by 55 · see citing works
Feng, B., Meng, R., Huang, B., Bi, Y., Shen, S., & Zhu, D. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.06.009 · Cited by 52 · see citing works
Zahan, M. S., Hasan, A., Rahman, M. H., Meem, K. N., Moni, A., Hannan, M. A., & Uddin, M. J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.04.192 · Cited by 52 · see citing works
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Self-citationWang, P., Xie, Z., Xie, C., Lin, C., Wang, J., Xuan, L., Zhang, C., Wang, Y., Huang, Z., & Teng, H. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12856 · Cited by 46 · see citing works
Luo, Y., Wu, M., Deng, B., Huang, J., Hwang, S. H., Li, M., Zhou, C., Zhang, Q., Yu, H., Zhao, D., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815746116 · Cited by 46 · see citing works
Chen, S., Chen, J., Li, S., Guo, F., Li, A., Wu, H., Chen, J., Pan, Q., Liao, S., Liu, J., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.786599 · Cited by 44 · see citing works
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Self-citationYi, W., Xie, X., Du, M., Bu, Y., Wu, N., Yang, H., Tian, C., Xu, F., Xiang, S., Zhang, P., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9032792 · Cited by 35 · see citing works
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Self-citationUddin, M. J., Pak, E. S., & Ha, H. (2018) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2018.22.5.567 · Cited by 29 · see citing works
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Cui, N., Zhang, W., Su, F., Zhang, Z., Li, B., Peng, D., Sun, Y., Zeng, Y., Yang, B., Kuang, H., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1255931 · Cited by 18 · see citing works
Zhang, J., Cheng, P., Dai, W., Ji, J., Wu, L., Feng, J., Wu, J., Yu, Q., Li, J., & Guo, C. (2021) · PPAR Research · doi:10.1155/2021/6658944 · Cited by 16 · see citing works
Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
Zahan, M. S., Ahmed, K. A., Moni, A., Sinopoli, A., Ha, H., & Uddin, M. J. (2021) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2022.26.1.1 · Cited by 16 · see citing works
Self-citationThe critical role of dysregulated autophagy in the progression of diabetic kidney disease
Zhang, Z., Sun, Y., Xue, J., Jin, D., Li, X., Zhao, D., Lian, F., Qi, W., & Tong, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.977410 · Cited by 15 · see citing works
Fenofibrate improves vascular endothelial function in diabetic mice
Xin, R., An, D., Li, Y., Fu, J., Huang, F., & Zhu, Q. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108722 · Cited by 15 · see citing works
Oxidative phosphorylation and fatty acid oxidation in slow-aging mice
Elmansi, A. M., & Miller, R. A. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.018 · Cited by 13 · see citing works
Elsayed, H. R. H., El‐Gamal, R., Rabei, M. R., Elhadidy, M. G., Hamed, S. M., Othman, B., Elshaer, M. M. A., Sedky, M. K., Hassan, A., & El-Nablaway, M. (2022) · Cells · doi:10.3390/cells11040746 · Cited by 12 · see citing works
Kundu, S., Hossain, K. S., Moni, A., Zahan, M. S., Rahman, M. M., & Uddin, M. J. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07460-8 · Cited by 12 · see citing works
Self-citationFriuli, M., Sepe, C., Panza, E., Travelli, C., Paterniti, I., & Romano, A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1407336 · Cited by 11 · see citing works
Kimura, H., Kamiyama, K., Imamoto, T., Takeda, I., Masunaga, S., Kobayashi, M., Mikami, D., Takahashi, N., Kasuno, K., Sugaya, T., et al. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101237 · Cited by 10 · see citing works
Martin, W. P., Chuah, Y. H. D., Abdelaal, M., Pedersen, A., Malmodin, D., Abrahamsson, S., Hutter, M., Godson, C., Brennan, E. P., Fändriks, L., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.757228 · Cited by 10 · see citing works
Alsaleem, M. A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Abdel‐Fattah, M. M., Alrouji, M., Al‐Harchan, N. A., Alruwaili, M., Papadakis, M., Alexiou, A. T., & Batiha, G. E. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70378 · Cited by 9 · see citing works
Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy
Ye, M., Yang, M., Dai, W., Li, H., Zhou, X. C., Chen, Y., & He, L. (2023) · Pharmaceuticals · doi:10.3390/ph16091256 · Cited by 9 · see citing works
Zhou, F., Li, X., Jia, K., Li, F., Xue, X., Liu, J., Qu, J., & Liu, R. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106581 · Cited by 9 · see citing works
Delaying Renal Aging: Metformin Holds Promise as a Potential Treatment
Qiao, Z., Zhao, J., Yuan, J., Qin, Y., Zhu, Z., Liu, J., & Sun, S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0168 · Cited by 9 · see citing works
Matsuta, K., Kamiyama, K., Imamoto, T., Takeda, I., Masunaga, S., Kobayashi, M., Takahashi, N., Kasuno, K., Hara, M., Iwano, M., et al. (2024) · Cells · doi:10.3390/cells13171446 · Cited by 9 · see citing works
Liu, T., Chen, X., Wei, Z., Han, X., Liu, Y., Ma, Z., Xia, T., & Gu, X. (2023) · Translational Neuroscience · doi:10.1515/tnsci-2022-0317 · Cited by 8 · see citing works
Fenofibrate differentially activates PPARα-mediated lipid metabolism in rat kidney and liver
Pannala, V. R., Balik-Meisner, M. R., Mav, D., Phadke, D. P., Scholl, E. H., Shah, R., Casey, W., Auerbach, S. S., & Wallqvist, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-20731-1 · Cited by 8 · see citing works
Song, S. Y., Lee, S. Y., Ko, Y. B., Kim, J., Choi, T., Lee, K. H., Yoo, H. J., & Yuk, J. (2022) · Gynecologic and Obstetric Investigation · doi:10.1159/000518509 · Cited by 6 · see citing works
High-Dose Fenofibrate Stimulates Multiple Cellular Stress Pathways in the Kidney of Old Rats
Wrońska, A., Kieżun, J., & Kmieć, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25053038 · Cited by 4 · see citing works
Harley, G., Katerelos, M., Gleich, K., Lee, M., Mount, P. F., & Power, D. A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280792 · Cited by 4 · see citing works
Shi, C., Li, R., Deng, L., Pan, D., Fu, Z., He, G., Qu, Y., Liu, R., Wang, X., Chen, X., et al. (2025) · Phytotherapy Research · doi:10.1002/ptr.70118 · Cited by 3 · see citing works
Effect and mechanism of Ganoderma leucocontextum extract on cadmium-toxic nephropathy
Zhang, L., Han, T., Qian, R., Xiao, Y., Zhu, W., & Xie, L. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.121104 · Cited by 3 · see citing works
Insights into nephroprotective potentials of luteolin and pharmacological advances: A Review
Mahamud, A. G. M. S. U., Tanvir, I. A., Kabir, E., Ahmed, K., Hosen, M. M., & Uddin, M. J. (2024) · Journal of Biologically Active Products from Nature · doi:10.1080/22311866.2024.2351023 · Cited by 2 · see citing works
Self-citationde Castro, B. B. A., Renó, P. F., Pereira, B. D. F., Arriel, K., Bonato, F. O. B., Colugnati, F. A. B., Cenedeze, M. A., Câmara, N. O. S., & Sanders‐Pinheiro, H. (2024) · Brazilian Journal of Nephrology · doi:10.1590/2175-8239-jbn-2023-0148en · Cited by 2 · see citing works
Bazı Popüler Diyetlerin İmmünite Üzerine Etkileri
Adıgüzel, E., KILIÇ, Ş. N., YILMAZ, A., YURDAKUL, G., BİLEN, Ü. D., TENİL, A., & YILMAZ, İ. (2022) · Black Sea Journal of Health Science · doi:10.19127/bshealthscience.1194776 · Cited by 2 · see citing works
Nutritional content and renoprotective potential of miracle tree (Moringa oleifera)
Sharma, V., Mahajan, G., & Gupta, R. (2025) · Biotechnologia · doi:10.5114/bta/204529 · Cited by 1 · see citing works
Shen, X., Li, G., Yao, J., Yang, J., Ding, X., Hao, Z., Chen, Y., & Yang, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1574157 · Cited by 1 · see citing works
Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle?
El-Bassouny, D. R., Mansour, A. A., Ellakkany, A. S., Ayuob, N. N., & AbdElfattah, A. A. (2023) · Histochemistry and Cell Biology · doi:10.1007/s00418-023-02205-5
“It is a peroxisome proliferator-activated receptor-α (PPAR-α) agonist that activates genes responsible for fatty acid metabolism as mitochondrial β-oxidation (Sohn et al. 2017).”
BackgroundFarjana, M., Moni, A., Sohag, A. A. M., Hasan, A., Hannan, A., Hossain, M. G., & Uddin, M. J. (2020) · doi:10.31219/osf.io/qamsw
Self-citationFarjana, M., Moni, A., Sohag, A. A. M., Hasan, A., Hannan, A., Hossain, M. G., & Uddin, M. J. (2020) · doi:10.31230/osf.io/smkvq
Self-citationde Castro, B. B. A., Renó, P. F., Pereira, B. D. F., Arriel, K., Bonato, F. O. B., Colugnati, F. A. B., Cenedeze, M. A., Câmara, N. O. S., & Sanders‐Pinheiro, H. (2024) · Brazilian Journal of Nephrology · doi:10.1590/2175-8239-jbn-2023-0148pt
范, 家. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1541172
Exploring Bilirubin’s Impact on Autophagy and Apoptosis in Diabetic Kidney Disease
Maleki, M. H., Dashti, Z. J. S., Monsef, A., Siri, M., Jamali, H., Naiebi, R., Omidi, F., Dehghanian, A., & Shafiee, S. M. (2026) · BioMed Research International · doi:10.1155/bmri/3801742
Potential of Small-Molecule Natural Products Against Autophagy Dysfunction in Kidney Diseases
Shoyshob, T. Z., Afrin, N., Islam, M. M., Farjana, M., Roni, M. T. A., Sen, M., Azam, M. S., Hridoy, A. I., Moni, A., & Uddin, M. J. (2026) · Immuno · doi:10.3390/immuno6020022
Self-citationLiu, Y., Long, L., Zang, J., Guo, C., Xiao, J., & Lin, G. (2026) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2026.100546
Zhang, M., Jumai, A., Wang, X., Zhou, Y., Ma, Y., & Wu, X. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103784
Pereira, M. M., Amorim, C. S., Gomes, A. C. C. D. A., Valença, H. D. M., Renovato‐Martins, M., Lanzetti, M., Valença, S. S., & Moraes, J. A. (2026) · Pharmaceuticals · doi:10.3390/ph19091414
Cheng, Y., Peng, L., Yang, K., Huang, N., Wang, Y., Zhang, Y., Liu, Y., Liu, C., & Sun, L. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48090942
- Authors
- Sohn, M., Kim, K., Uddin, M. J., Lee, G., Hwang, I., Kang, H., Kim, H., Lee, J. H., & Ha, H.
- Affiliations
- Ewha Womans University (KR)
- Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea
- Corresponding author
- Ha, Hunjoo
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2017-02-01
- Volume
- 312
- Issue
- 2
- Pages
- F323-F334
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2501972755
- Cited by
- 80
- References
- 48
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 15 · 2021: 8 · 2020: 10 · 2019: 5 · 2018: 4 · 2017: 5
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Science and Technology (Korean Ministry of Education, Science and Technology) (2012R1A2A1A0300692 and 2016R1A2B4006575, 2015H1D3A1062189)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- fenofibrate, AMPK, autophagy, high-fat diet, kidney injury, PPARα, fatty acid oxidation, antioxidants, albuminuria, glomerulosclerosis, proximal tubular epithelial cells, insulin resistance, renal protection, treatment delay
- MeSH terms
- Albuminuria, Animals, Hypolipidemic Agents, Autophagy, Diabetic Nephropathies, Dose-Response Relationship, Drug, Insulin Resistance, Kidney Tubules, Proximal, Phosphorylation, Fenofibrate, Signal Transduction, Protective Agents, Mice, AMP-Activated Protein Kinases, Diet, High-Fat
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