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Aldosterone and postprandial renal excretion of sodium and potassium in sheep
Abstract
When sheep rapidly eat a meal of dry feed a period of antinatriuresis and antidiuresis is rapidly initiated and lasts for 2-3 hrs. This is followed by a postprandial period of natriuresis and diuresis. This study tested the hypothesis that the postprandial natriuresis was due to a reduction in the secretion of aldosterone. In unanesthetized ewes of about 50 kg body wt, measurements were made of sodium and potassium excretion beginning in the terminal phase of the feed-induced antinatriuresis and continuing through the period of postprandial natriuresis. Aldosterone, given by constant infusion at a physiological dose (10 microgram/h), inhibited the natriuresis. Spironolactone, a competitive inhibitor of aldosterone given as a single intravenous injection of 5 mg/kg body wt, did not significantly increase the natriuresis. These results support the stated hypothesis. Neither aldosterone nor spironolactone had a significant effect on potassium excretion. This finding supports earlier view that aldosterone has only a small role in the homeostatic control of potassium excretion in sheep.
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“K+ intake has been shown to activate a feedforward control in which distal tubule K+ secretion is stimulated before changes in plasma K+ concentration or ALD concentration can be observed [1, 15–18].”
From A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls (2022) · cites this paper as [16]
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Regulation of the Renal NaCl Cotransporter and Its Role in Potassium Homeostasis
Hoorn, E. J., Gritter, M., Cuevas, C. A., & Fenton, R. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00044.2018 · Cited by 163
Narrative Review: Evolving Concepts in Potassium Homeostasis and Hypokalemia
Greenlee, M., Wingo, C. S., McDonough, A. A., Youn, J.-H., & Kone, B. C. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-9-200905050-00008 · Cited by 104
Aldosterone and potassium homeostasis
Rabinowitz, L. (1996) · Kidney International · doi:10.1038/ki.1996.258 · Cited by 104
Self-citationSpecies dependent gentamicin pharmacokinetics and nephrotoxicity in the young horse
Riviere, J. E., Coppoc, G. L., Hinsman, E. J., et al. (1983) · Fundamental and Applied Toxicology · doi:10.1016/s0272-0590(83)80020-7 · Cited by 49
Epstein, M., & Lifschitz, M. D. (2016) · Kidney International Reports · doi:10.1016/j.ekir.2016.03.001 · Cited by 25
A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls
Stadt, M. M., Leete, J., Devinyak, S., & Layton, A. T. (2022) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1010607 · Cited by 19
Epstein, M., & Lifschitz, M. D. (2016) · Kidney International Supplements · doi:10.1016/j.kisu.2016.01.006 · Cited by 19
“Almost 30 years ago, Rabinowitz et al.44 conducted a series of elegant experiments in sheep that demonstrated that potassium intake in food or potassium placed into the rumen (sheep stomach) was associated with a large and significant increase in urinary potassium excretion.”
InfluentialRenal Na excretion in dehydrated and rehydrated adrenalectomized sheep maintained with aldosterone
McKinley, M. J., Evered, M. D., & Mathai, M. L. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.1.r17 · Cited by 19
“In addition to the aforementioned effects of cerebral lesions preventing dehydration-induced natriuresis (1, 15, 24), experimentally induced reduction of the Na concentration of the cerebrospinal fluid also prevents the increase of Na excretion in dehydrated animals (9, 13, 16, 22), which is further evidence of a role…”
BackgroundInfluentialAtrial pressure and postprandial volume regulation in conscious dogs
Kaczmarczyk, G., Schimmrich, B., Mohnhaupt, R., & Reinhardt, H. W. (1979) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00582345 · Cited by 18
“Results concerning the role of mineralocorticoid activity in pp UNa l> are inconclusive, perhaps because of the different species used [3, 23].”
ResultIrsik, D. L., Blazer‐Yost, B. L., Staruschenko, A., & Brands, M. W. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00354.2016 · Cited by 9
“The ability to eliminate 406 an acute salt load has been attributed to many factors, such as withdrawal of the renin407 angiotensin-aldosterone system (5, 36), increased natriuretic peptide (12, 39, 46), 408 withdrawal of renal sympathetic nerve activity (32, 35), hemodynamic factors (20), and gut409 derived hormones…”
BackgroundProgesterone: not just a sex hormone anymore?
Wingo, C. S., & Greenlee, M. M. (2011) · Kidney International · doi:10.1038/ki.2011.131 · Cited by 7
POSTPRANDIAL VOLUME REGULATION AND RENIN-ANGIOTENSIN SYSTEM IN CONSCIOUS DOGS
Kaczmarczyk, G., Echt, M., Mohnhaupt, R., et al. (1981) · Elsevier eBooks · doi:10.1016/b978-0-08-026824-8.50086-2 · Cited by 6
Clegg, L. E., Chu, L., Någård, M. B., Boulton, D. W., & Penland, R. C. (2023) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.13084 · Cited by 2
Metadata
- Authors
- Rabinowitz, L., Denham, S. C., & Gunther, R. A.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1977-09-01
- Volume
- 233
- Issue
- 3
- Pages
- F213-F216
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2202991822
- Cited by
- 14
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2017: 1 · 2016: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- aldosterone, antinatriuresis, antidiuresis, renal sodium excretion, renal potassium excretion, spironolactone, sheep, potassium homeostasis
- MeSH terms
- Aldosterone, Animals, Feeding Behavior, Female, Kidney, Natriuresis, Potassium, Sheep, Spironolactone
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