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Aldosterone and postprandial renal excretion of sodium and potassium in sheep
Abstract
When sheep rapidly eat a meal of dry feed a period of antinatriuresis and antidiuresis is rapidly initiated and lasts for 2-3 hrs. This is followed by a postprandial period of natriuresis and diuresis. This study tested the hypothesis that the postprandial natriuresis was due to a reduction in the secretion of aldosterone. In unanesthetized ewes of about 50 kg body wt, measurements were made of sodium and potassium excretion beginning in the terminal phase of the feed-induced antinatriuresis and continuing through the period of postprandial natriuresis. Aldosterone, given by constant infusion at a physiological dose (10 microgram/h), inhibited the natriuresis. Spironolactone, a competitive inhibitor of aldosterone given as a single intravenous injection of 5 mg/kg body wt, did not significantly increase the natriuresis. These results support the stated hypothesis. Neither aldosterone nor spironolactone had a significant effect on potassium excretion. This finding supports earlier view that aldosterone has only a small role in the homeostatic control of potassium excretion in sheep.
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“K+ intake has been shown to activate a feedforward control in which distal tubule K+ secretion is stimulated before changes in plasma K+ concentration or ALD concentration can be observed [1, 15–18].”
From A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls (2022) · cites this paper as [16]
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Regulation of the Renal NaCl Cotransporter and Its Role in Potassium Homeostasis
Hoorn, E. J., Gritter, M., Cuevas, C. A., & Fenton, R. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00044.2018 · Cited by 163
Narrative Review: Evolving Concepts in Potassium Homeostasis and Hypokalemia
Greenlee, M., Wingo, C. S., McDonough, A. A., Youn, J.-H., & Kone, B. C. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-9-200905050-00008 · Cited by 104
Aldosterone and potassium homeostasis
Rabinowitz, L. (1996) · Kidney International · doi:10.1038/ki.1996.258 · Cited by 104
Self-citationSpecies dependent gentamicin pharmacokinetics and nephrotoxicity in the young horse
Riviere, J. E., Coppoc, G. L., Hinsman, E. J., et al. (1983) · Fundamental and Applied Toxicology · doi:10.1016/s0272-0590(83)80020-7 · Cited by 49
Epstein, M., & Lifschitz, M. D. (2016) · Kidney International Reports · doi:10.1016/j.ekir.2016.03.001 · Cited by 25
Metadata
- Authors
- Rabinowitz, L., Denham, S. C., & Gunther, R. A.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1977-09-01
- Volume
- 233
- Issue
- 3
- Pages
- F213-F216
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2202991822
- Cited by
- 14
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2017: 1 · 2016: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- aldosterone, antinatriuresis, antidiuresis, renal sodium excretion, renal potassium excretion, spironolactone, sheep, potassium homeostasis
- MeSH terms
- Aldosterone, Animals, Feeding Behavior, Female, Kidney, Natriuresis, Potassium, Sheep, Spironolactone
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