The DOI matches its Crossref record.
Mineralocorticoid effects on Na-K-ATPase in individual nephron segments
Abstract
A fluorometric micromethod for the assay of Na-K-ATPase was used to determine Na-K-ATPase activity in 11 segments of the rabbit nephron. The Na-K-ATPase activity was found to be highest (greater than 100 pmol.mm1-.min-1) in proximal convoluted tubules (S1), medullary thick ascending limbs, distal convoluted tubules, and connecting tubules. There was a good correlation (r = 0.94) between Na-K-ATPase activity in different segments and net Na transport previously measured by in vitro tubule perfusion. Treatment of rabbits with deoxycorticosterone (DOCA) for 8-11 days produced increases in Na-K-ATPase activity of 100 and 500% in connecting tubules and cortical collecting ducts, respectively, without significant change in other segments. Maintenance on a low sodium diet for 12-18 days was associated with a 200% increase in Na-K-ATPase activity in cortical collecting ducts only. We conclude that the Na-K-ATPase activity is stimulated by mineralocorticoids in the cortical collecting duct in association with the previously observed changes in sodium transport.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Enzyme distribution along the nephron
Guder, W. G., & Ross, B. D. (1984) · Kidney International · doi:10.1038/ki.1984.143 · Cited by 503
Field, M. J., Stanton, B. A., & Giebisch, G. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111598 · Cited by 140
Representation and relative abundance of cell-type selective markers in whole-kidney RNA-Seq data
Clark, J. Z., Chen, L., Chou, C.-L., Jung, H. J., Lee, J. W., & Knepper, M. A. (2019) · Kidney International · doi:10.1016/j.kint.2018.11.028 · Cited by 136
Self-citation
Metadata
- Authors
- Garg, L. C., Knepper, M. A., & Burg, M. B.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1981-06-01
- Volume
- 240
- Issue
- 6
- Pages
- F536-F544
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W1755620559
- Cited by
- 223
- References
- 0
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mineralocorticoid effects on Na-K-ATPase in individual nephron segments. https://app.cochat.ai/papers/10.1152/ajprenal.1981.240.6.f536
- The paper
- Garg, L. C., Knepper, M. A., & Burg, M. B. (1981). Mineralocorticoid effects on Na-K-ATPase in individual nephron segments. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.1981.240.6.f536
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
