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Cited by 140Potassium and Related DisordersIon Transport and Channel RegulationHormonal Regulation and Hypertension

Differential acute effects of aldosterone, dexamethasone, and hyperkalemia on distal tubular potassium secretion in the rat kidney

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Field, M J, Stanton, B A, Giebisch, G H·1984·Journal of Clinical Investigation
DOI 10.1172/jci111598PMC PMC425359
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Abstract

To determine the specific effects on renal potassium transport of acute elevations in plasma aldosterone, dexamethasone, and potassium concentrations, we studied adrenalectomized rats prepared such that each factor could be varied independently. Clearance data alone could not be used to deduce the underlying tubular transport effects, however, since infusion of each of these agents was associated with a marked change in urinary flow rate, which may itself have influenced potassium excretion. We therefore used a technique of continuous microperfusion, in vivo, of single superficial distal tubules to evaluate potassium secretion at constant luminal flow rate during each experimental maneuver. Acute aldosterone infusion was associated with a 90% stimulation of potassium secretion by microperfused tubules. However, total kidney sodium excretion and urinary flow rate were markedly reduced, and these factors opposed the direct tubular action of aldosterone, resulting in no net change in the amount of potassium excreted into the final urine. Conversely, dexamethasone had no direct effect on potassium secretion by single microperfused tubules, but it caused a sharp increase in urinary flow and sodium excretion, and secondarily enhanced urinary potassium excretion by 50%. Hyperkalemia per se stimulated renal potassium excretion both via a direct tubular effect and by increasing urinary flow rate. We conclude that urinary potassium excretion after infusion of each of these agents represents the net result of direct tubular effects and secondary flow-mediated changes.

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  • In adult male Sprague-Dawley rats, an increase in plasma aldosterone concentration from 4.4 ng/dl to 55.8 ng/dl causes distal tubule K+ secretion to increase by 83%.

    “Field et al. [33] found that in adult male Sprague-Dawley rats, an increase in plasma ALD concentration from 4.4 ng/dl to 55.8 ng/dl caused distal tubule secretion to increase by 83%.”

    From A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls (2022) · cites this paper as [33]

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Research works printed but not linked: 2

  1. Hierholzer, K., and S. Lange. 1975. The effects of adrenal steroids on renal function. In MTP International Review Science: Kidney and Urinary Tract Physiology. K. Thurau, editor. Butterworth & Co., London. 273-334.
  2. Snedecor, G. W., and W. G. Cochran. 1980. Statistical Methods. Iowa State Univ. Press, Ames, IA. Seventh ed.

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Authors
Field, M. J., Stanton, B. A., & Giebisch, G. H.
Affiliations
Yale University (US)
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1984-11-01
Volume
74
Issue
5
Pages
1792-1802
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci111598
PMC
PMC425359
OpenAlex
W2066970340
Cited by
140
References
45
Citations by year
2026: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 4 · 2014: 8 · 2013: 3 · 2012: 3
FWCI
12.90
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Royal Australasian College of Physicians
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
aldosterone, dexamethasone, hyperkalemia, renal potassium excretion, urinary flow rate, sodium excretion, adrenalectomy, glucocorticoids, renal tubular transport
MeSH terms
Aldosterone, Animals, Dexamethasone, Glomerular Filtration Rate, Hydrogen-Ion Concentration, Kidney Tubules, Kidney Tubules, Distal, Male, Potassium, Rats, Inbred Strains, Water-Electrolyte Balance, Rats

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