Effect of renal nerve stimulation on NaCl and H2O transport in Henle's loop of the rat
Abstract
To assess the effect of renal nerve stimulation on sodium, chloride, and water transport in the loop of Henle, experiments were performed in anesthetized hydropenic and isotonic saline volume-expanded rats using renal clearance and Henle's loop microperfusion techniques (end-proximal convoluted tubule perfusion site, early distal convoluted tubule collection site). As compared with the control period values, low-frequency (less than 1.0 Hz) renal nerve stimulation decreased absolute and fractional urinary flow rate and sodium and chloride excretion without affecting mean arterial pressure, glomerular filtration rate, renal blood flow, or renal vascular resistance. In the loop of Henle, the absorptive transport of water was not affected, whereas the absorptive transport of sodium and chloride was increased in both hydropenic (Na 111 +/- 49 peq/min) and isotonic saline volume-expanded rats (Na 154 +/- 69 peq/min, Cl 180 +/- 52 peq/min) during low-frequency renal nerve stimulation. Low-frequency renal nerve stimulation decreases urinary sodium and chloride excretion via a direct effect of increasing renal tubular sodium and chloride reabsorption. In addition to the established effect of increasing proximal tubular sodium reabsorption, Henle's loop sodium and chloride absorption are also increased, supporting a physiological role for the adrenergic innervation of these structures.
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In the thick ascending limb, α1B-AR activation raises Na+-K+-ATPase activity.
“In the thick ascending limb, activation of α1B-AR results in increased Na+-K+-ATPase activity27.”
From Renal nerves in physiology, pathophysiology and interoception (2025) · cites this paper as [27]
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“Therefore, efferent renal fibers can directly control tubular functions, and neural ef~cts are exerted at different nephron levels: the proximal tubule [20, 22], the ascending limb of Henle's loop [23], and the distal tubule [24].”
BackgroundThe kidney in cardiac failure: today’s perspective
Gross, P., Schadt, M., Passauer, J., Werner, D., & Büssemaker, E. (1998) · doi:10.1007/978-94-011-5482-6_84 · Cited by 1
Alterations in Kidney Function Associated With Heart Failure
Polonsky, T. S., & Bakris, G. (2020) · doi:10.1016/b978-0-323-60987-6.00015-6
Renal Denervation: A Historical Perspective
Papademetriou, V., Doumas, M., Tsioufis, C., & Raman, V. (2016) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-34141-5_13
- Authors
- DiBona, G. F., & Sawin, L. L.
- ORCID
- DiBona, G. F.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1982-12-01
- Volume
- 243
- Issue
- 6
- Pages
- F576-F580
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2410105647
- Cited by
- 110
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2020: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 9
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- renal nerve stimulation, loop of Henle, sodium transport, chloride transport, water transport, sodium reabsorption, chloride reabsorption, adrenergic innervation, hydropenia, sodium excretion, urinary chloride excretion
- MeSH terms
- Animals, Blood Pressure, Body Water, Electric Stimulation, Glomerular Filtration Rate, Inulin, Kidney, Kidney Tubules, Kidney Tubules, Proximal, Loop of Henle, Male, Perfusion, Peripheral Nerves, Rats, Inbred Strains, Sodium Chloride, Rats
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