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Cited by 75Ion channel regulation and functionHormonal Regulation and HypertensionRenin-Angiotensin System Studies

The DOI matches its Crossref record; 51 of the 53 references it cites were found in a registry or an index.

A role for T-type Ca2+channels in the synergistic control of aldosterone production by ANG II and K+

Chen, Xiao-Liang, Bayliss, Douglas A., Fern, Robert J., Barrett, Paula Q.·1999·American Journal of Physiology-Renal Physiology
DOI 10.1152/ajprenal.1999.276.5.f674
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Abstract

Independently, plasma K+ and ANG II stimulate aldosterone secretion from adrenal glomerulosa (AG) cells, but together they synergistically control production. We studied mechanisms to mediate this synergy using bovine AG cells studied under physiological conditions (in 1.25 mM Ca2+ at 37 degrees C). Increasing K+ from 2 to 5 mM caused a potentiation of ANG II-induced aldosterone secretion and a substantial membrane depolarization ( approximately 21 mV). ANG II inhibited a K+-selective conductance in both 2 and 5 mM K+ but caused only a slight depolarization because, under both conditions, membrane potential was close to the reversal potential of the ANG II-induced current. ANG II activated calcium/calmodulin-dependent protein kinase II (CaMKII) equivalently in 2 and 5 mM K+. However, CaMKII activation caused a hyperpolarizing shift in the activation of T-type Ca2+ channels, such that substantially more current was elicited at membrane potentials established by 5 mM K+. We propose that synergy in aldosterone secretion results from K+-induced depolarization and ANG II-induced modulation of T-type channel activation, such that together they promote enhanced steady-state Ca2+ flux.

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Crossref · 10.1152/ajprenal.1999.276.5.f674

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2 of the 53 references couldn’t be matched to a known paper.

Research works printed but not linked: 8

  1. Barrett P. Q., 1991, Am. J. Physiol., 261, F706
  2. Brauneis U., 1991, Am. J. Physiol., 260, E772
  3. Fern R. J., 1995, Am. J. Physiol., 269, F751
  4. Hollenberg N. K., 1975, Clin. Sci. Mol. Med., 49, 527
  5. Kanazirska M. V., 1992, Am. J. Physiol., 263, E760
  6. Lu H. K., 1994, Am. J. Physiol., 267, F183
  7. Payet M. D., 1995, Mol. Endocrinol., 9, 935
  8. Vassilev P. M., 1992, Am. J. Physiol., 263, E752

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Metadata

Authors
Chen, X.-L., Bayliss, D. A., Fern, R. J., & Barrett, P. Q.
Affiliations
  • Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908
  • University of Virginia (US)
ORCID
Venue
American Journal of Physiology-Renal Physiology
Publisher
American Physiological Society
Published
1999-05-01
Volume
276
Issue
5
Pages
F674-F683
ISSN
  • 1522-1466 (ISSN-L)
  • 1931-857X
DOI
10.1152/ajprenal.1999.276.5.f674
OpenAlex
W2185003919
Cited by
75
References
53
Citations by year
2026: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 7 · 2013: 2 · 2012: 7
FWCI
1.61
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Renal Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL036977, HL36977)
  • National Institute of Neurological Disorders and Stroke (NS33583)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
T-type calcium channels, aldosterone secretion, angiotensin II, potassium, adrenal glomerulosa cells, membrane depolarization, calcium/calmodulin-dependent protein kinase II, synergistic hormone action, calcium flux
MeSH terms
Adenosine Triphosphate, Aldosterone, Angiotensin II, Animals, Cattle, Drug Synergism, Guanosine Triphosphate, Membrane Potentials, Potassium, Calcium Channels, Potassium Channels, Zona Glomerulosa, Ion Channel Gating, Calcium-Calmodulin-Dependent Protein Kinases, Patch-Clamp Techniques, Calcium Channels, T-Type, Calcium-Calmodulin-Dependent Protein Kinase Type 2, In Vitro Techniques

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