Estrogen-induced cardiorenal protection: potential cellular, biochemical and molecular mechanisms.
Abstract
A number of cellular and biochemical processes are involved in the pathophysiology of glomerular and vascular remodeling, leading to renal and vascular disorders, respectively. Although estradiol protects the renal and cardiovascular systems, the mechanisms involved remain unclear. In this review we provide a discussion of the cellular, biochemical, and molecular mechanisms by which estradiol may exert protective effects on the kidneys and vascular wall. In this regard, we consider the possible role of genomic vs. nongenomic mechanisms and estrogen receptor-dependent vs. estrogen receptor-independent mechanisms in mediating the protective effects of estradiol on the renal and cardiovascular systems.
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Estrogen and progesterone receptors occur in nonreproductive tissues that regulate fluid, including the hypothalamus, cardiovascular system, and kidney tubules.
“Receptors for estrogens and progesterone are found in nonreproductive tissue involved in fluid regulation, such as the hypothalamus (10,21), the cardiovascular system (6,19), and the kidney tubules (6).”
From Sex Hormone Effects on Body Fluid Regulation (2008) · cites this paper as [6]
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References 318 · Cited by 263
- Authors
- Dubey, R. K., & Jackson, E. K.
- Affiliations
- University Hospital Zurich (CH)
- University of Pittsburgh Medical Center (US)
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2001-03-01
- Volume
- 280
- Issue
- 3
- Pages
- F365-F388
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2186358774
- Cited by
- 263
- References
- 318
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 12
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl055314-07, 5r01hl035909-12)
- National Heart, Lung, and Blood Institute (HL-55314, HL-35909)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- estradiol, estrogen, cardiorenal protection, renal protection, vascular protection, vascular remodeling, genomic estrogen signaling, non-genomic estrogen signaling, estrogen receptor, cardioprotection
- MeSH terms
- Animals, Cardiovascular System, Cardiovascular Physiological Phenomena, Estradiol, Humans, Kidney, Genome, Protective Agents
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