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Cited by 62Cardiovascular and exercise physiologyMuscle metabolism and nutritionExercise and Physiological Responses

Splanchnic metabolism in exercising man

Rowell, Loring B., Masoro, Edward J., Spencer, Michael J.·1965·Journal of Applied Physiology
DOI 10.1152/jappl.1965.20.5.1032
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Abstract

Using a single injection of indocyanine green dye, estimated hepatic plasma and blood flow were determined in six normal young males during the 30th to 60th min of exercise requiring 10–12 kcal/min (2.04– 2.49 liters O2 per min). Subjects were fasted 15–18 hours. During hepatic flow measurements four determinations of splanchnic A-V differences of triglyceride (TG), free fatty acid (FFA), phospholipid (PL), ketone bodies, and glucose were made from radial arterial and hepatic venous sampling sites. Splanchnic A-V concentration differences for TG and PL varied randomly with time from positive to negative values indicating no net production whereas FFA was uniformly taken up by splanchnic organs at an average rate of 64 μm/min. Average splanchnic ketone body production was 20 mg/min and glucose production averaged 295 mg/min. Complete oxidation by skeletal muscle of lipid substrate released by splanchnic organs could account for less than 5% of total caloric expenditure; glucose production accounted for an average of 10.4%. One to two determinations of splanchnic A-V lactate, CO2, and O2 concentrations in four men indicated continued uptake of lactate (average 50 mg/min) during exercise with RQ values approaching zero. lipid metabolism; exercise, hepatic blood flow, and metabolism; energy metabolism Submitted on January 15, 1965

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  • During moderate-intensity exercise, hepatic glucose production increases threefold from resting conditions.

    “During moderate-intensity exercise, the hepatic glucose production was shown to increase threefold from resting conditions [113]”

    From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [113]

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Authors
Rowell, L. B., Masoro, E. J., & Spencer, M. J.
Affiliations
University of Washington (US)
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1965-09-01
Volume
20
Issue
5
Pages
1032-1037
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1965.20.5.1032
OpenAlex
W8505727
Cited by
62
References
0
Citations by year
2023: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2014: 1 · 2013: 2
FWCI
2.80
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
splanchnic metabolism, physical activity, hepatic blood flow, hepatic plasma flow, indocyanine green, arteriovenous differences, free fatty acid uptake, triglyceride metabolism, phospholipid metabolism, ketone synthesis, hepatic glucose production, lactate utilization, respiratory quotient, lipid oxidation, skeletal muscle
MeSH terms
Adult, Blood, Carbon Dioxide, Physical Exertion, Fatty Acids, Glucose, Glycerides, Humans, Ketone Bodies, Lactates, Liver Circulation, Male, Muscles, Oxygen Consumption, Phospholipids

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