Pulmonary circulation in the aged.
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Reduced alveolar-capillary density and changes to pulmonary vasculature result in a gradual decrease in pulmonary capillary blood volume with aging.
“Reduced alveolar-capillary density as well as changes to pulmonary vasculature result in a gradual decrease in pulmonary capillary blood volume with aging (24–28).”
From Aging and Lung Disease (2020) · cites this paper as [28]
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“(Table 1) [8-10,12-31]After the exclusion of individuals with prospectively defined implausible data, n=222 subjects (n=147 male, n=33 female, n=42 gender not available) were analysed.”
BackgroundPulmonary vascular structure and function in chronic obstructive pulmonary disease.
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Distensibility of the normal human lung circulation during exercise
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“The value appeared slightly reduced in older men, particularly those 70 yr of age, as might be expected if, as reported, of the pulmonary arteries fall in the aged (6).”
BackgroundRoman, M. A., Rossiter, H. B., & Casaburi, R. H. (2016) · European Respiratory Journal · doi:10.1183/13993003.00347-2016 · Cited by 195 · see citing works
“[113, 114] Decreased pulmonary vascular compliance, along with decreased LV compliance,[112] leads to increased pulmonary arterial (PA) pressure, pulmonary wedge pressure and pulmonary vascular resistance in older individuals.[115, 116] PA pressure increase appears to be secondary to vascular stiffening and decreased…”
BackgroundInfluence of aging on lung function--clinical significance of changes from age twenty.
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“Pulmonary vascular resistance [PVR1⁄4 (Ppa Ppw) blood flow], also increases progressively with healthy aging.(6,7,10) Similar to the age-associated increases in Ppa, the absolute increase in vascular resistance is greater in the systemic circulation than in the pulmonary circulation.”
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The normal pulmonary arterial pressure-flow relationships during exercise
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Impact of age on pulmonary artery systolic pressures at rest and with exercise
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Self-citationChanges in pulmonary hemodynamics with aging in a predominantly hypertensive population
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A Canine Model of Torsades de Pointes
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“The rate of rise of pressure during exercise increases after pneumonectomy (Cournand et al, 1950) and after balloon-occlusion of one pulmonary artery (Emirgil et al, 1967).”
BackgroundEmirgil, C., Sobol, B. J., Herbert, W. H., & Trout, K. W. (1971) · The American Journal of Medicine · doi:10.1016/0002-9343(71)90148-3 · Cited by 23 · see citing works
Self-citationHypoxaemia in elderly patients suffering from fractured neck of femur*
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The pulmonary artery in the normal aged lung
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The Mechanobiology of Vascular Remodeling in the Aging Lung
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“…individual data taken from studies cited in the appendix and Johnson et al. (1960), Reeves et al. (1961), Åstrand et al. (1964), Frick and Somer (1964), Emirgil et al. (1967), Hermansen et al. (1970), Jones et al. (1970), Pernow and Saltin (1971), and Capderou et al. (1997). cRER = VCO 2 /VO 2…”
BackgroundMethodInfluentialPulmonary Blood Volume Among Older Adults in the Community: The MESA Lung Study
Hermann, E. A., Motahari, A., Hoffman, E. A., Allen, N. B., Bertoni, A. G., Bluemke, D. A., Eskandari, A., Gerard, S. E., Guo, J., Hiura, G. T., et al. (2022) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.122.014380 · Cited by 15 · see citing works
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“Mean pulmonary artery pressure Also in agreement with previous studies, mPAP rose during exercise in both younger and older individuals (Emirgil et al. 1967; Ehrsam et al. 1983; Reeves et al. 2005; Kovacs et al. 2009; Van Empel et al. 2014).”
BackgroundResultInfluentialNormal pulmonary pressure-flow relationship during exercise in the sitting position
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“14,18,19 Although previous studies have primarily considered concomitant left ventricular diastolic dysfunction or systemic hypertension (increasing PAWP) as the main cause of increased pulmonary pressures in elderly subjects, age was found to be an independent factor to PAWP in our study.”
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- Authors
- Emirgil, C., Sobol, B. J., Campodonico, S., Herbert, W. H., & Mechkati, R.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1967-11
- Volume
- 23
- Issue
- 5
- Pages
- 631-640
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2413616926
- Cited by
- 74
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- pulmonary circulation, aging, older adults, pulmonary hemodynamics, pulmonary vascular function
- MeSH terms
- Adult, Aged, Aging, Blood Pressure, Cardiac Output, Physical Exertion, Female, Heart Ventricles, Hemodynamics, Humans, Male, Middle Aged, Pulmonary Artery, Pulmonary Circulation, Vascular Resistance
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