Plasma norepinephrine response to exercise before and after training in humans
Abstract
Plasma norepinephrine (NE) concentration was measured by means of a sensitive radioenzymatic assay in blood collected from an antecubital vein in 10 healthy male subjects (37 +/- 2 yr, mean +/- SE). The subjects were evaluated at rest and during exercise before and after a 20-wk training program on bicycle ergometer (three 30-min sessions per week at 80% of maximal heart rate). Following the training program, maximal oxygen uptake increased significantly from 33 +/- 2 to 42 +/- 1 ml . kg-1 . min-1. Resting plasma NE remained unchanged after training (167 +/- 38 before and 185 +/- 29 pg . ml-1 after training). For a given absolute work load (735 +/- 51 kg . m. min-1) the sympathetic nervous response was lower after training as reflected by the decrease in NE concentration (1,371 +/- 286 vs. 687 +/- 64 pg . ml-1). At the same relative work load (heart rate: 158 +/- 5 before and 157 +/- 5 beats . min-1 after training) plasma NE concentration was unchanged after training (1,371 +/- 286 vs. 1,729 +/0 371 pg . ml-1). Results from the present study show that the sympathetic nervous activity is closely linked to the exercise demands and confirm earlier suggestions that it remains constant in relation to the relative work load.
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“Acute bouts of exercise activate the sympathetic nervous system and decrease vagal activity, leading to an acute increase in susceptibility to ventricular fibrillation.26”
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- Authors
- Peronnet, F., Cleroux, J., Perrault, H., Cousineau, D., de Champlain, J., & Nadeau, R.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1981-10-01
- Volume
- 51
- Issue
- 4
- Pages
- 812-815
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2147719848
- Cited by
- 144
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 2 · 2019: 3 · 2018: 1 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- plasma norepinephrine, physical activity, training, sympathetic activity, bicycle ergometer training, VO2max, heart rate
- MeSH terms
- Adult, Physical Exertion, Heart Rate, Humans, Male, Norepinephrine, Physical Education and Training
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