Exercise-mediated effects on white and brown adipose tissue plasticity and metabolism

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Changes in diet and lifestyle and long-term weight gain in women and men

Mozaffarian, D., Hao, T., Rimm, E. B., Willett, W. C., & Hu, F. B. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1014296 · Cited by 2,527 · see citing works

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318 · see citing works

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,241 · see citing works

The effects of acute and chronic exercise on <scp>PGC</scp> ‐1α, irisin and browning of subcutaneous adipose tissue in humans

Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Jensen, J., & Drevon, C. A. (2014) · The FEBS Journal · doi:10.1111/febs.12619 · Cited by 563 · see citing works

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

de Jesus, L. A., Carvalho, S. D., Ribeiro, M. O., Schneider, M. J., Kim, S.-W., Harney, J. W., Larsen, P. R., & Bianco, A. C. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113803 · Cited by 537 · see citing works

Adipose Tissue Quantification by Imaging Methods: A Proposed Classification

Shen, W., Wang, Z., Punyanita, M., Lei, J., Sınav, A., Kral, J. G., Imielińska, C., Ross, R., & Heymsfield, S. B. (2003) · Obesity Research · doi:10.1038/oby.2003.3 · Cited by 510 · see citing works

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

Kajimura, S., Seale, P., Tomaru, T., Erdjument-Bromage, H., Cooper, M. P., Ruas, J. L., Chin, S., Tempst, P., Lazar, M. A., & Spiegelman, B. M. (2008) · Genes &amp; Development · doi:10.1101/gad.1666108 · Cited by 468 · see citing works

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

Vitali, A., Murano, I., Zingaretti, M. C., Frontini, A., Ricquier, D., & Cinti, S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m018846 · Cited by 461 · see citing works

Physical activity and resting metabolic rate

Speakman, J. R., & Selman, C. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2003282 · Cited by 441 · see citing works

Transdifferentiation properties of adipocytes in the adipose organ

Cinti, S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00183.2009 · Cited by 379 · see citing works

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

Sánchez-Gurmaches, J., Hung, C., Sparks, C. A., Tang, Y., Li, H., & Guertin, D. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.003 · Cited by 342 · see citing works

Evidence against a Beneficial Effect of Irisin in Humans

Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 322 · see citing works

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

Schumacher, M. A., Chinnam, N. B., Ohashi, T., Shah, R., & Erickson, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.516641 · Cited by 240 · see citing works

Luxuskonsumption, diet-induced thermogenesis and brown fat: the case in favour

Rothwell, N. J., & Stock, M. J. (1983) · Clinical Science · doi:10.1042/cs0640019 · Cited by 229 · see citing works

Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL

Gaidhu, M. P., Fediuc, S., Anthony, N. M., So, M., Mirpourian, M., Perry, R. L. S., & Ceddia, R. B. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800480-jlr200 · Cited by 200 · see citing works

Thermogenic Capacity Is Antagonistically Regulated in Classical Brown and White Subcutaneous Fat Depots by High Fat Diet and Endurance Training in Rats

Wu, M. V., Bikopoulos, G. J., Hung, S., & Ceddia, R. B. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.591008 · Cited by 184 · see citing works

Plasma norepinephrine response to exercise before and after training in humans

Peronnet, F., Cleroux, J., Perrault, H., Cousineau, D., de Champlain, J., & Nadeau, R. (1981) · Journal of Applied Physiology · doi:10.1152/jappl.1981.51.4.812 · Cited by 144 · see citing works

Brown Fat in Humans: Consensus Points and Experimental Guidelines

Cypess, A. M., Haft, C. R., Laughlin, M. R., & Hu, P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.025 · Cited by 137 · see citing works

Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation.

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α2 Adrenergic Receptor-Mediated Inhibition of Thermogenesis

Madden, C. J., Tupone, D., Cano, G., & Morrison, S. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4701-12.2013 · Cited by 106 · see citing works

Dynamic changes in lipid droplet-associated proteins in the “browning” of white adipose tissues

Barneda, D., Frontini, A., Cinti, S., & Christian, M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.015 · Cited by 105 · see citing works

The Effects of Temperature and Seasons on Subcutaneous White Adipose Tissue in Humans: Evidence for Thermogenic Gene Induction

Kern, P. A., Finlin, B. S., Zhu, B., Rasouli, N., McGehee, R. E., Westgate, P. M., & Dupont‐Versteegden, E. E. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2440 · Cited by 103 · see citing works

Thermogenic Activity of UCP1 in Human White Fat-Derived Beige Adipocytes

Bartesaghi, S., Hallén, S., Huang, L., Svensson, P., Momo, R. A., Wallin, S., Carlsson, E. K., Forslöw, A., Seale, P., & Peng, X. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1295 · Cited by 101 · see citing works

PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1Preprint

Iida, S., Chen, W., Nakadai, T., Ohkuma, Y., & Roeder, R. G. (2015) · Genes & Development · doi:10.1101/gad.252809.114 · Cited by 94 · see citing works

PGC-1α Is Required for Exercise- and Exercise Training-Induced UCP1 Up-Regulation in Mouse White Adipose Tissue

Ringholm, S., Knudsen, J. G., Leick, L., Lundgaard, A., Nielsen, M. M., & Pilegaard, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064123 · Cited by 78 · see citing works

Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity

Gaidhu, M. P., Frontini, A., Hung, S., Pistor, K., Cinti, S., & Ceddia, R. B. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m015354 · Cited by 69 · see citing works

Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a 6‐month exercise intervention

Rönn, T., Volkov, P., Tornberg, Å. B., Elgzyri, T., Hansson, O., Eriksson, K., Groop, P., & Ling, C. (2014) · Acta Physiologica · doi:10.1111/apha.12247 · Cited by 68 · see citing works

Modulation in vivo of β-adrenergic-receptor subtypes in rat brown adipose tissue by the thermogenic agonist Ro 16–8714

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Lipolysis, lipogenesis, and adiposity are reduced while fatty acid oxidation is increased in visceral and subcutaneous adipocytes of endurance-trained rats

Pistor, K., Sepa-Kishi, D. M., Hung, S., & Ceddia, R. B. (2014) · Adipocyte · doi:10.4161/21623945.2014.955423 · Cited by 25 · see citing works

Effect of running training on uncoupling protein mRNA expression in rat brown adipose tissue

Yamashita, H., Yamamoto, M., Sato, Y., et al. (1993) · International Journal of Biometeorology · doi:10.1007/bf01212769 · Cited by 19 · see citing works

Exercise-training reduces BAT thermogenesis in rats

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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works

Exercise-induced ’browning’ of adipose tissues

Aldiss, P., Betts, J., Sale, C., Pope, M., Budge, H., & Symonds, M. E. (2018) · Metabolism · doi:10.1016/j.metabol.2017.11.009 · Cited by 175 · see citing works

Looking on the “brite” side exercise-induced browning of white adipose tissue

Townsend, L. K., & Wright, D. C. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2177-1 · Cited by 44 · see citing works

Brown Adipose Tissue: More Than an Effector of Thermogenesis?a

Cannon, B., Houštěk, J., & Nedergaard, J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08325.x · Cited by 124 · see citing works

Influence of amphetamine on brown adipose thermogenesis.

Pj, W. (1983) · PubMed · Cited by 12 · see citing works

Do estrogens enhance activation of brown and beiging of adipose tissues?

Frank, A. P., Palmer, B. F., & Clegg, D. J. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.09.026 · Cited by 37 · see citing works

Application limitations of sympathetic nerve-mediated thermogenesis of brown/ beige adipose tissue in the treatment of obesity

Ma, D., Jiang, P., & Wang, Y. (2017) · Zhonghua neifenmi daixie zazhi · doi:10.3760/cma.j.issn.1000-6699.2017.07.018

Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice

Fischer, A. W., Behrens, J. R., Sass, F., Schlein, C., Heine, M., Pertzborn, P., Scheja, L., & Heeren, J. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000455 · Cited by 21 · see citing works