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Mode of neural control mediating rat tail vasodilation during heating
Abstract
The purpose of this investigation was to delineate the mode of efferent neural control mediating rat tail vasodilation during body heating. Tail blood flow (venous occlusion plethysmography), tail skin temperature over the ventral vascular bundle, and arterial pressure were measured in Sprague-Dawley rats anesthetized with pentobarbital sodium (45 mg/kg). Three protocols were followed: anesthesia of the lumbar sympathetic chain, bilateral lumbar sympathectomy, and sympathetic nerve stimulation during varying degrees of alpha-adrenergic receptor blockade. Mean tail blood flow and tail vascular conductance (TVC) during body heating were 40.3 +/- 8.7 ml X 100 ml-1 X min-1 and 39.2 +/- 9.2 ml X 100 ml-1 X min-1 X 100 mmHg-1, respectively. Interruption of sympathetic nerve activity by sympathetic nerve anesthetization or sympathectomy during heat stress caused a nonsignificant increase in TVC to 112.7 +/- 1.8 and 121.12 +/- 6.3%, respectively, of the values achieved with body heating. Sympathectomy performed in normothermic animals that had recovered from prior heating caused an increase in TVC to 128.4 +/- 14.0% of the levels achieved during the previous heating period. In addition, sympathetic nerve stimulation after complete alpha-adrenergic receptor blockade failed to produce a vasodilation [control TVC = 10.2 +/- 3.9 vs. TVC during nerve stimulation = 10.4 +/- 3.9 (P greater than 0.05)]. It is concluded that the increase in TVC during body heating occurs solely via a reduction in vasoconstrictor nerve activity.
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“Because vasodilatation in the rat is accomplished by inhibiting vasoconstriction (O’Leary et al., 1985), these data show a vasodilator effect of NK3R MnPO neuron activation in neutral ambient temperatures, that is suppressed in the subneutral environment.”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as O’Leary et al., 1985
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Rácz, I., & Zimmer, A. (2006) · doi:10.1002/9783527611942.ch9 · Cited by 1,659
Le Bars, D., Gozariu, M., & Cadden, S. W. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01514-x · Cited by 1,459
Central neural pathways for thermoregulation
Shaun, F. M. (2010) · Frontiers in bioscience · doi:10.2741/3677 · Cited by 671
“In contrast, rats do not appear to have a cholinergic sympathetic vasodilator system (106) and thus the thermoregulatory control of blood flow to the rat tail is primarily dependent on the level of CVC sympathetic outflow (107).”
BackgroundRance, N. E., Dacks, P. A., Mittelman-Smith, M. A., Romanovsky, A. A., & Krajewski-Hall, S. J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.07.003 · Cited by 380
“Because vasodilatation in the rat is accomplished by inhibiting vasoconstriction (O’Leary et al., 1985), these data show a vasodilator effect of NK3R MnPO neuron activation in neutral ambient temperatures, that is suppressed in the subneutral environment.”
BackgroundChanges in cutaneous and body temperature during and after conditioned fear to context in the rat
Vianna, D. M. L., & Carrive, P. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04073.x · Cited by 327
“Skin temperature depends on skin blood flow and sympathetic vasoconstrictor tone in skin arteries (Hertzman, 1953; Felder et al., 1954; Rand et al., 1965; Hales et al., 1978; O’Leary et al., 1985; Janig & McLachlan, 1992; Owens et al., 2002; Blessing & Seaman, 2003).”
Background
Metadata
- Authors
- O'Leary, D. S., Johnson, J. M., & Taylor, W. F.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1985-11-01
- Volume
- 59
- Issue
- 5
- Pages
- 1533-1538
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2394598000
- Cited by
- 104
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL20663)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- body heating, sympathetic nervous system, lumbar sympathectomy, sympathetic activation, alpha-adrenergic blockade, tail blood flow, heat stress, skin blood flow
- MeSH terms
- Animals, Body Temperature Regulation, Hot Temperature, Male, Neurons, Efferent, Rats, Inbred Strains, Skin, Sympathetic Nervous System, Tail, Vasodilation, Rats
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