Cited by 190Cardiovascular and exercise physiologyMuscle metabolism and nutritionSports Performance and Training

The DOI matches its Crossref record.

Disposal of blood [1-13c] lactate in humans during rest and exercise

Mazzeo, R. S., Brooks, G. A., Schoeller, D. A., Budinger, T. F.·1986·Journal of Applied Physiology

DOI 10.1152/jappl.1986.60.1.232

Open this paper in CoChat — free account

Abstract

Lactate irreversible disposal (RiLa) and oxidation (RoxLa) rates were studied in six male subjects during rest (Re), easy exercise [EE, 140 min of cycling at 50% of maximum O2 consumption (VO2max)] and hard exercise (HE, 65 min at 75% VO2max). Twenty minutes into each condition, subjects received a Na+-L(+)-[1-13C]lactate intravenous bolus injection. Blood was sampled intermittently from the contralateral arm for metabolite levels, acid-base status, and enrichment of 13C in lactate. Expired air was monitored continuously for determination of respiratory parameters, and aliquots were collected for determination of 13C enrichment in CO2. Steady-rate values for O2 consumption (VO2) were 0.33 +/- 0.01, 2.11 +/- 0.03, and 3.10 +/- 0.03 l/min for Re, EE, and HE, respectively. Corresponding values of blood lactate levels were 0.84 +/- 0.01, 1.33 +/- 0.05, and 4.75 +/- 0.28 mM in the three conditions. Blood lactate disposal rates were significantly correlated to VO2 (r = 0.78), averaging 123.4 +/- 20.7, 245.5 +/- 40.3, and 316.2 +/- 53.7 mg X kg-1 X h-1 during Re, EE, and HE, respectively. Lactate oxidation rate was also linearly related to VO2 (r = 0.81), and the percentage of RiLa oxidized increased from 49.3% at rest to 87.0% during exercise. A curvilinear relationship was found between RiLa and blood lactate concentration. It was concluded that, in humans, 1) lactate disposal (turnover) rate is directly related to the metabolic rate, 2) oxidation is the major fate of lactate removal during exercise, and 3) blood lactate concentration is not an accurate indicator of lactate disposal and oxidation.

Integrity signals

Registry

Crossref · 10.1152/jappl.1986.60.1.232

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–190 of 190

Forearm muscle metabolism studied using 31P-MRS during progressive exercise to fatigue after Acz administration
Kowalchuk, J. M., Smith, S. A., Weening, B. S., et al. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.200 · Cited by 23
“However, as [La(2)]pl represents a balance between plasma La(2) appearance and disappearance (21, 36), the lower [La(2)]pl after Acz administration must be related to either 1) increased La(2) uptake from blood into active and inactive muscle and other tissues, 2) increased mitochondrial oxidation of pyruvate, La(2),…”
Background
Blood lactate concentrations during incremental exercise in subjects with sickle cell trait
BILÉ, A., GALLAIS, D. L., Mercier, B., et al. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199805000-00002 · Cited by 23
Chronic Post-Exercise Lactate Administration with Endurance Training Increases Glycogen Concentration and Monocarboxylate Transporter 1 Protein in Mouse White Muscle
Hoshino, D., Hanawa, T., Takahashi, Y., Masuda, H., Kato, M., & Hatta, H. (2014) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.60.413 · Cited by 22
Blood lactate levels as a biomarker of antipsychotic side effects in patients with schizophrenia
Elmorsy, E. M., Shahda, M., Mahmoud, E.-H. M., Rakha, S. A., & Shoaib, M. C. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115616385 · Cited by 22
Bioenergetics of Exercising Humans
Brooks, G. A. (2012) · Comprehensive physiology · doi:10.1002/j.2040-4603.2012.tb00407.x · Cited by 23
Self-citation
The blood lactate/pyruvate equilibrium affair
Brooks, G. A., Osmond, A. D., Leija, R. G., Curl, C. C., Arevalo, J. A., Duong, J. J., & Horning, M. A. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00270.2021 · Cited by 22
Self-citation
Effect of Magnesium Lactate Dihydrate and Calcium Lactate Monohydrate on 20-km Cycling Time Trial Performance
Peveler, W. W., & Palmer, T. G. (2012) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31822dcd7f · Cited by 22
“During exercise, it is more likely that lactate is being oxidized in nonworking muscles as opposed to those directly involved in exercise, therefore not adding to energy transfer directly related to human movement (11,14,18,21,25).”
Background
Comparison of incremental and steady state tests of endurance training
Denis, C., Dormois, D., Castells, J., Bonnefoy, R., Padilla, S., GEYSSANT, A., & Lacour, J. R. (1988) · European Journal of Applied Physiology · doi:10.1007/bf00417996 · Cited by 19
Respective oxidation of13C-labeled lactate and glucose ingested simultaneously during exercise
Péronnet, F., Burelle, Y., Massicotte, D., Lavoie, C., & Hillaire‐Marcel, C. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.2.440 · Cited by 20
Effect of post-exercise lactate administration on glycogen repletion and signaling activation in different types of mouse skeletal muscle
Takahashi, K., Kitaoka, Y., Matsunaga, Y., & Hatta, H. (2020) · Current Research in Physiology · doi:10.1016/j.crphys.2020.07.002 · Cited by 20
Blood lactate levels of decathletes during competition.
Beaulieu, P., OTTOZ, H., Grange, C., et al. (1995) · British Journal of Sports Medicine · doi:10.1136/bjsm.29.2.80 · Cited by 18
V-A and A-V modes in whole body and regional kinetics: domain of validity from a physiological model
Saccà, L., TOFFOLO, G. M., & Cobelli, C. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.4.e597 · Cited by 18
Determination of δ13C values of plasma lactate by gas chromatography/isotope ratio mass spectrometry
Khalfallah, Y., Normand, S., Tissot, S., et al. (1993) · Journal of Mass Spectrometry · doi:10.1002/bms.1200221207 · Cited by 18
What the Lactate Shuttle Means for Sports Nutrition
Brooks, G. A. (2023) · Nutrients · doi:10.3390/nu15092178 · Cited by 21
Self-citation
Diet-induced obesity accelerates blood lactate accumulation of rats in response to incremental exercise to maximum
Chen, C., Liao, Y., Lin, S.-Y., Yu, J.-X., Li, Z.-J., Lin, Y.-C., Chang, G., Lin, C.-H., & Wong, M. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00337.2016 · Cited by 17
“The high level of blood lactate is cleared mainly by oxidation (in high-oxidative cells such as type I muscle fibers, heart, and brain) and via gluconeogenesis (in liver and kidney) (14, 17).”
Background
The effect of pre-test carbohydrate ingestion on the anaerobic threshold, as determined by the lactate-minimum test
Rotstein, A., Dotan, R., Zigel, L., et al. (2007) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h07-066 · Cited by 15
Anaerobic capacity assessment in elite swimmers through inertial sensors
Demarie, S., Chirico, E., Gianfelici, A., et al. (2019) · Physiological Measurement · doi:10.1088/1361-6579/ab205d · Cited by 14
Quantifications of Lipid KineticsIn VivoUsing Stable Isotope Tracer Methodology
Kim, I., Park, S., Jang, J., & Wolfe, R. R. (2020) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2020.9.1.110 · Cited by 14
The Effects of Smoking on Exercise Performance
Huie, M. J. (1996) · Sports Medicine · doi:10.2165/00007256-199622060-00003 · Cited by 14
Are Arterial, Muscle and Working Limb Lactate Exchange Data Obtained on Men at Altitude Consistent with the Hypothesis of an Intracellular Lactate Shuttle?
Brooks, G. A. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4711-2_16 · Cited by 13
Self-citation
Partial purification and reconstitution of the sarcolemmal l -lactate carrier from rat skeletal muscle
Allen, P. J., & Brooks, G. A. (1994) · Biochemical Journal · doi:10.1042/bj3030207 · Cited by 13
Self-citation
Effect of Three Kinds of Severe Repeated Exercises on Blood Lactate Concentrations in Thoroughbred Horses on a Treadmill
Eto, D., Hada, T., Kusano, K., Kai, M., & KUSUNOSE, R. (2004) · Journal of Equine Science · doi:10.1294/jes.15.61 · Cited by 12
“is performed using the lactate that has accumulated in muscle as a substrate [2, 7].”
BackgroundMethod
Hyperpolarized Functional Magnetic Resonance of Murine Skeletal Muscle Enabled by Multiple Tracer-Paradigm Synchronizations
Leftin, A., Roussel, T., & Frydman, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096399 · Cited by 12
“Another possibility is that these fibers are reflecting an early intravasation of muscle lactate, known to occur over longer intervals poststimulation [38].”
Background
Metabolic Support of Moderate Activity Differs from Patterns Seen after Extreme Behavior in the Desert IguanaDipsosaurus dorsalis
Donovan, E. R., & Gleeson, T. T. (2006) · Physiological and Biochemical Zoology · doi:10.1086/501055 · Cited by 12
Association of Blood Metabolomics Biomarkers with Brain Metabolites and Patient-Reported Outcomes as a New Approach in Individualized Diagnosis of Schizophrenia
Krzyściak, W., Bystrowska, B., Karcz, P., Chrzan, R. M., Bryll, A., Turek, A., Mazur, P., Śmierciak, N., Szwajca, M., Donicz, P., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042294 · Cited by 11
“This positive correlation of cortisol and glutamate level indicates an excitotoxic effect on the hippocampus induced by glutamate [111].”
Background
Ergoespirometria em atletas paraolímpicos brasileiros
da Silva, A. C., & Torres, F. C. (2002) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922002000300008 · Cited by 10
A study of lactate metabolism without tracer during passive and active postexercise recovery in humans
Francaux, M., Jacqmin, P. A., de Welle, J. M., et al. (1995) · European Journal of Applied Physiology · doi:10.1007/bf00964115 · Cited by 10
Heart rate and plasma lactate responses to training in andalusian horses
Agüera, E. I., Rubio, D., Vivo, R., Santisteban, R., Agüera, S., Muñoz, A., & Castejón, F. M. (1995) · Journal of Equine Veterinary Science · doi:10.1016/s0737-0806(07)80423-0 · Cited by 10
Effects of exogenous lactate on lipid, protein, and glucose metabolism—a randomized crossover trial in healthy males
Pedersen, M. G. B., Rittig, N. F., Bangshaab, M., Hansen, K. B., Gopalasingam, N., Gormsen, L. C., Søndergaard, E., & Møller, N. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00301.2023 · Cited by 13
Effect of dichloroacetate on oxidative removal of lactate in mice after supramaximal exercise
Hatta, H., Soma, R., & Atomi, Y. (1991) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(91)90220-8 · Cited by 9
Pyruvate dehydrogenase activation in inactive muscle during and after maximal exercise in men
Putman, C. T., Matsos, M. P., Hultman, E., Jones, N. L., & Heigenhauser, G. J. F. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.3.e483 · Cited by 9
“Increases in LA uptake (1, 2, 4, 10, 19, 21) and LA turnover (7, 22, 25) in inactive muscles have been demonstrated in both human (1, 4, 8, 19, 21) and animal models (7, 10, 25) of exercise (1, 4, 8, 19, 21) and LA infusion during rest (2, 7, 10, 22, 25, 30) and exercise (1, 4, 7, 8, 22).”
Background
Lactate metabolism in trauma
Goodwin, M. L., & Rothberg, D. L. (2014) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000000162 · Cited by 8
Measuring lactate production
Stanley, W. C., & Brooks, G. A. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.253.4.e472 · Cited by 8
Self-citation
Limiting carbohydrate stores: alleviating the problem in the marathon runner, a hibernating lizard, and the neonate brain
Guppy, M. (1988) · Canadian Journal of Zoology · doi:10.1139/z88-160 · Cited by 8
Hyperglycemia Suppresses Lactate Clearance During Exercise in Type 1 Diabetes
ROMERES, D., YADAV, Y. R., RUCHI, F., Carter, R. E., Cobelli, C., Basu, R., & Basu, A. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae005 · Cited by 7
A comparative study of interval and continuous incremental training in Thoroughbreds
Bronsart, L. L., Sides, R. H., & Bayly, W. M. (2009) · Comparative Exercise Physiology · doi:10.1017/s1755254009990080 · Cited by 7
Distribution of lactate and other ions in inactive skeletal muscle: influence of hyperkalemic lactacidosis
Chin, E. R., Lindinger, M. I., & Heigenhauser, G. J. F. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-75-12-1375 · Cited by 8
Distribution of lactate and other ions in inactive skeletal muscle: influence of hyperkalemic lactacidosis
Chin, E. R., Lindinger, M. I., & Heigenhauser, G. J. F. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y97-180 · Cited by 7
Early lactate and glucose kinetics following return to spontaneous circulation after out-of-hospital cardiac arrest
Jorge, P. F., Boer, R., Posma, R. A., Harms, K. C., Hiemstra, B., Bens, B. W. J., & Nijsten, M. W. (2021) · BMC Research Notes · doi:10.1186/s13104-021-05604-w · Cited by 6
“Exercise studies demonstrated that—when available— lactate is preferentially consumed in comparison to substrates such as glucose [3, 6, 7].”
Background
Premorbid beta blockade in sepsis is associated with a lower risk of a lactate concentration above the lactate threshold, a retrospective cohort study
Schneider, L., Chalmers, D., O’Beirn, S., Greenberg, M., & Cave, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-25253-8 · Cited by 6
Metabolomic responses to high-intensity interval exercise in equine skeletal muscle: effects of rest interval duration
Takahashi, K., Mukai, K., Takahashi, Y., Ebisuda, Y., Hatta, H., & Kitaoka, Y. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.246896 · Cited by 6
Effect of short-term heat acclimation training on kinetics of lactate removal following maximal exercise.
Dileo, T. D., Powell, J. B., Kang, H. K., Roberge, R. J., Coca, A., & Kim, J.-H. (2016) · PubMed · Cited by 6
In Vivo and In Vitro Quantification of Glucose Kinetics: From Bedside to Bench
Kim, I., Park, S., Kim, Y., Chang, Y., Choi, C. S., Suh, S., & Wolfe, R. R. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.406 · Cited by 6
The maximum lactate clearance: A new concept to approach the endurance level of an athlete
Francaux, M., Jacqmin, P. A., & Sturbois, X. (1993) · Archives of Physiology and Biochemistry · doi:10.3109/13813459308998130 · Cited by 6
Variations in lactate apparent clearance during rest and exercise in normal man
Francaux, M., Jacqmin, P. A., Sturbois, X., & Sturbois, P. X. (1993) · Archives of Physiology and Biochemistry · doi:10.3109/13813459309003929 · Cited by 6
Ammonium Ion and the Anaerobic Threshold in Man
Systrom, D. M., Fragoso, C. V., Kanarek, D. J., et al. (1991) · CHEST Journal · doi:10.1378/chest.99.5.1197 · Cited by 6
Understanding of Lactate
송윤경, Suh, S., & Jeon, J. Y. (2017) · Korean Journal of Sport Science · doi:10.24985/kjss.2017.28.1.1 · Cited by 5
Simple kinetic model for the study of lactate metabolic adaptation to exercise in sportsmen routine evaluation
Francaux, M., Jacqmin, P. A., & Sturbois, X. (1989) · Archives Internationales de Physiologie et de Biochimie · doi:10.3109/13813458909075063 · Cited by 5
1H NMR Determination of lactate 13C‐enrichment in skeletal muscle: Using a double quantum filter for the simultaneous editing of 13C‐coupled and 13C‐uncoupled methyl protons resonance
Bloch, G., Jouvensal, L., & Carlier, P. G. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340312 · Cited by 5
Effects of conditioning on the left ventricular function of young purebred Arabian horses
Ramos, G. V., Santos, M. M., Gava, F. N., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304724 · Cited by 4
A MATHEMATICAL MODEL FOR TRAINING IMPULSE AND LACTATE INFLUX AND OUTFLUX DURING EXERCISE
Moxnes, J. F., & Hausken, K. (2009) · International Journal of Modern Physics C · doi:10.1142/s0129183109013522 · Cited by 4
Other Ingredients
Horswill, C. A. (2000) · Nutrition in exercise and sport · doi:10.1201/9781420037180.ch9 · Cited by 4
Application of modeling to lactate kinetics in exercise.
Fukuba, Y. (1990) · The Annals of physiological anthropology · doi:10.2114/ahs1983.9.203 · Cited by 4
Lactate dynamics in Parkinson’s disease: striatal circuit vulnerability, biomarker potential, and therapeutic windows
Kong, J., Yang, Z., Wang, Y., Liu, L., Liu, Y., & Chen, W. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01551-z · Cited by 4
Lactato: De Causa da Fadiga a Suplemento Ergogênico?
Pinto, C. L., Painelli, V. D. S., Lancha, A. H., & Artioli, G. G. (2014) · Revista Brasileira de Ciência e Movimento · doi:10.18511/0103-1716/rbcm.v22n2p173-181 · Cited by 3
Lactate Threshold: The Comparison of Running on a Land Treadmill Versus Head-Out Water Immersion Treadmill Running
Jones, S. A. (2009) · ScholarsArchive (Brigham Young University) · Cited by 2
The changes in lactate levels and body weight during a regional and single Triathlon competition in Sergipe, Brazil
Sousa, R. A. L. D., dos Santos, J. L., Hugo-Melo, V., et al. (2014) · Scientia Plena · Cited by 3
Relationships between rate of increase in post-exercise blood lactate concentration and performance of short-term high-intensity exercise in track athletes
Takei, N., Takahashi, K., Kakinoki, K., et al. (2018) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.7.253 · Cited by 3
Le proton: exercice et fatigue
Callier, J., Rouillon, J. D., Rieu, M., & Magnin, P. (1996) · Science & Sports · doi:10.1016/0765-1597(96)81289-5 · Cited by 3
Eight weeks of inorganic nitrate/nitrite supplementation improves aerobic exercise capacity and the gas exchange threshold in patients with type 2 diabetes
Bock, J. M., Hanson, B. E., Miller, K. A., Seaberg, N. T., Ueda, K., Feider, A. J., Hanada, S., Lira, V. A., & Casey, D. P. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00478.2022 · Cited by 2
Estimación del gasto energético en actividades de corta duración y alta intensidad
Montaner, B. H. V., & Gómez-Puerto, J. R. (2012) · Revista Andaluza de Medicina del Deporte · doi:10.1016/s1888-7546(12)70023-0 · Cited by 2
Recovery levels after eccentric and concentric loading in maximal force
Örer, G. E., Güzel, N. A., & Arslan, E. (2016) · Journal of Physical Therapy Science · doi:10.1589/jpts.28.1743 · Cited by 2
Muscle Fuel Utilization with Glycolysis Viewed Right Side Up
Brooks, G. A. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_1 · Cited by 2
Self-citation
The Mader model of muscle energy metabolism simulates key metabolic exercise phenomena
Rothschild, J. A., Dunst, A. K., Axsom, J., Wackerhage, H., & Heck, H. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2525555123 · Cited by 1
What Do We Know of Human Fuel Use during Aerobic Exercise, and How Do We Know It?
Axsom, J., & Arany, Z. P. (2025) · Physiology · doi:10.1152/physiol.00002.2025 · Cited by 3
Lactate Shuttling and the Mitochondrial Lactate Oxidation Complex
Brooks, G. A. (2012) · Oxidative stress and disease · doi:10.1201/b12308-10 · Cited by 3
Self-citation
Regulation of Glycemia and Energy Substrate Partitioning in Exercising Humans
Emhoff, C. W. (2013) · eScholarship (California Digital Library) · Cited by 1
İSKELET ve KALP KASLARINDA LAKTİK ASİTİN TAŞINIMI: MONOKARBOKSİL TAŞIYICI PROTEİNLER BÖLÜM I
Hazır, T., & Açıkada, C. (2005) · Spor Bilimleri Dergisi Hacettepe Üniversitesi · doi:10.17644/sbd.07956
Differences in training programs and time trial performances of teenage sprint freestyle swimmers
Stratman, J. A. (2013)
Lactate musculaire chez le rat: méthode de dosage simplifiée
Duvallet, A., Verdier, J. C., Serrurier, B., et al. (1989) · Science & Sports · doi:10.1016/s0765-1597(89)80044-9
The relationship between an increased aerobic power and the excess post exercise oxygen consumption
Cannon, E. W. (2009) · cIRcle (University of British Columbia) · doi:10.14288/1.0077062
“Type I fibers have in fact been shown to possess the respiratory capacity sufficient to oxidize large quantities of lactate (Bonen and Belcastro, 1976; Brooks, 1986; Mazzeo et al., 1986; Stanley, 1991).”
Background
monocarboxylate transporter MCT1 Cardiac and skeletal muscle mitochondria have a
Brooks, G. A., Brown, M. A., Butz, C. E., Sicurello, J. P., Hashimoto, T., Hussien, R., Oommen, S., Gohil, K., Kane, D. A., Elustondo, P. A., et al. (2015)
Self-citation
moderately overweight men: a randomized controlled trial Independent effects of endurance training and weight loss on peak fat oxidation in
Brooks, G. A., Friedlander, A. L., Casazza, G. A., Ušaj, A., Møller, N., Nielsen, S. L., Jessen, N., Otto, J., Bibby, B. M., Vissing, K., et al. (2015)
Self-citation
administrationprogressive exercise to fatigue after Acz
Paterson, D. H., Kowalchuk, J. M., Smith, S. A., et al. (2015)
The response of lactic acid, heart rate, and oxygen consumption to varying intensities of resistance exercise
Rosenau, L. W. (1987) · ThinkTech (Texas Tech University)
Examining The Influence of Recovery Strategy and Rest Interval Length on Performance in Trained and Untrained Individuals
Pettit, N. R. (2015)
Estimación del gasto energético en actividades de corta duración y alta
Viana-Montaner, B. H. (2013)
Lactate, A Phoenix Rising in Contemporary BiologyPreprint
Brooks, G. A. (2020) · Preprints.org · doi:10.20944/preprints202009.0299.v1
Self-citation
Biology and Medicine Division: Annual report 1986
Lab., C. (. S. L. B. (1987) · doi:10.2172/5594908
Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance
Park, S., Cha, H.-N., Shin, M., et al. (2024) · doi:10.2337/figshare.25665438.v1
Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance
Park, S., Cha, H.-N., Shin, M., et al. (2024) · doi:10.2337/figshare.25665438
Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance
Park, S., Cha, H.-N., Shin, M., et al. (2024) · doi:10.2337/figshare.25665438.v2
Blood lactate steady state during interval training: new perspectives on something already known
Mazza, J. C., Festa, R. R., Gurovich, A. N., & Jannas-Vela, S. (2024) · International journal of exercise science · doi:10.70252/ufgu3343
“During continuous and incremental exercise, lactate appearance and disappearance rates (i.e., lactate turnover); can increase BLa levels up to 4-5 mmol/L (28) and to ~10 mmol/L (37), respectively.”
Background
Lactate Transport and Exchange During Exercise
Gladden, L. B. (1995) · Comprehensive physiology · doi:10.1002/j.2040-4603.1995.tb01711.x
The Stress Response, Stress Hyperglycemia and Stress Hyperlactemia
Marik, P. E. (2014) · Springer eBooks · doi:10.1007/978-3-319-11020-2_13 · Cited by 1
Additional file 1 of Early lactate and glucose kinetics following return to spontaneous circulation after out-of-hospital cardiac arrest
Jorge, P. F., Boer, R., Posma, R. A., Harms, K. C., Hiemstra, B., Bens, B. W. J., & Nijsten, M. W. (2021) · Figshare · doi:10.6084/m9.figshare.14594460
Effets des facteurs matériels sur le développement de la fatigue neuromusculaire en tennis
Fabre, J.-B. (2014) · theses.fr (ABES) · doi:10.70675/003443d6z700az48ceza8d1zff5dfd410e12
Électrostimulation neuromusculaire et récupération à court terme : implications dans la performance du sportif de haut niveau
Borne, R. (2016) · theses.fr (ABES) · doi:10.70675/f4e6cebfz14b2z492bzacefzd1d1a2df66d1
Lactate Biology: Subcellular Routing and Chemical Form Define Function
Offei, N. A., & Cluntun, A. A. (2026) · Biochemistry · doi:10.1021/acs.biochem.6c00251 · Cited by 1
Plasma Lactate Accumulation During Running with Body Weight Unloading by LBPP
Rasmussen, N. N. (2013) · ScholarsArchive (Brigham Young University)

Authors: Mazzeo, R. S., Brooks, G. A., Schoeller, D. A., & Budinger, T. F.
ORCID: Brooks, G. A.
Schoeller, D. A.
Budinger, T. F.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1986-01-01
Volume: 60
Issue: 1
Pages: 232-241
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1986.60.1.232
OpenAlex: W1952016433
Cited by: 189
References: 0
Citations by year: 2026: 4 · 2025: 2 · 2024: 13 · 2023: 1 · 2022: 8 · 2021: 9 · 2020: 10 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 8
FWCI: 12.43
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AM-195 77)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: blood lactate, lactate oxidation, physical activity, oxygen consumption, blood lactate concentration, metabolic rate, acid-base status, cycling exercise
MeSH terms: Adult, Bicarbonates, Blood Glucose, Carbon Dioxide, Carbon Isotopes, Physical Exertion, Homeostasis, Humans, Lactates, Male, Metabolic Clearance Rate, Oxidation-Reduction, Oxygen Consumption, Respiration, Rest

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Disposal of blood [1-13c] lactate in humans during rest and exercise

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks