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Cited by 39Cardiovascular and exercise physiologyThermoregulation and physiological responsesExercise and Physiological Responses

Progressive elevations in muscle blood flow during prolonged exercise in swine

Armstrong, R. B., Delp, M. D., Goljan, E. F., Laughlin, M. H.·1987·Journal of Applied Physiology
DOI 10.1152/jappl.1987.63.1.285
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Abstract

Distribution of muscle blood flow has not been measured in man during prolonged exercise, but progressive elevations in skin flow coupled with constant cardiac output (QT) have suggested muscle blood flow may be compromised. However, previous experiments with rats demonstrated progressive increases in muscle blood flow over time during prolonged submaximal exercise. The present study was performed to study muscle blood flow in miniature swine during long-term exercise to shed light on this apparent anomaly. QT and distribution of QT were studied with radiolabeled microspheres while pigs ran on a level treadmill at a speed (10.5 km/h) requiring 71 +/- 4% of maximal O2 consumption (VO2 max). QT increased 23% from the 5th to the 30th min of exercise, whereas total skeletal muscle flow increased by 49%. Increases in flow in the muscles resulted from decreased resistance, since mean arterial pressure declined over this time period (-7%). In addition, the proportional increases in muscle flow were similar within synergistic muscle groups independent of fiber type composition (e.g., elbow extensors: 59–78%; elbow flexors: 26–40%). The factor that limited continued exercise appeared to be body temperature. Colonic temperature rose in linear fashion over time; the animals became exhausted at approximately 42 degrees C. These flow data are similar to previous findings in rats and indicate that during prolonged treadmill locomotion in quadrupedal animals muscle blood flow increases over time to near maximal levels.

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Crossref · 10.1152/jappl.1987.63.1.285

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  • Swine have a large heart rate reserve, increasing from approximately 89-117 bpm at rest to 259-306 bpm during exercise.

    “Swine have a large heart rate reserve as they can increase their heart rates from approximately 89–117 bpm at rest to 259–306 bpm during exercise (Armstrong, Delp, Goljan, & Laughlin, 1987; Delp, et al., 2001; Krombach, et al., 1998; Roth, et al., 1990).”

    From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Armstrong, et al., 1987

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Authors
Armstrong, R. B., Delp, M. D., Goljan, E. F., & Laughlin, M. H.
ORCID
Delp, M. D.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1987-07-01
Volume
63
Issue
1
Pages
285-291
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1987.63.1.285
OpenAlex
W2427813604
Cited by
39
References
14
Citations by year
2025: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2013: 1 · 2012: 2
FWCI
3.90
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (7r01am037098-01)
  • National Heart, Lung, and Blood Institute (HL36088, HL 01774)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
muscle blood flow, prolonged exercise, skeletal muscle blood flow, cardiac output, microsphere distribution, arterial pressure, body temperature, exercise fatigue, treadmill running, pigs, muscle fiber composition, elbow extensors, elbow flexors
MeSH terms
Animals, Blood Pressure, Cardiac Output, Physical Exertion, Female, Heart Rate, Muscles, Organ Specificity, Oxygen Consumption, Regional Blood Flow, Swine, Swine, Miniature

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