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Cited by 172Cardiovascular and exercise physiologyMuscle metabolism and nutritionMuscle activation and electromyography studies

Motor drive and metabolic responses during repeated submaximal contractions in humans

Vollestad, N. K., Sejersted, O. M., Bahr, R., Woods, J. J., Bigland-Ritchie, B.·1988·Journal of Applied Physiology
DOI 10.1152/jappl.1988.64.4.1421
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Abstract

Contractile failure during various types of exercise has been attributed to intramuscular metabolic changes. We examined the temporal changes in force-generating capacity and metabolic state during intermittent isometric contractions in humans. One-legged quadriceps contractions at 30% maximum voluntary contraction (MVC) were executed for 6 s, with 4 s of rest between. The decrease in force-generating capacity was tested from brief MVC's and short bursts of 50-Hz stimulation applied at 5-min intervals. After 1 min of exercise, the MVC force declined linearly and in parallel to the 50-Hz stimulation force, indicating that the contractile failure was due to intramuscular processes. After 30 min of exercise the MVC force had declined by approximately 40% compared with the value obtained after 1 min. In separate experiments the same contraction protocol was followed, but two-legged contractions were used. Muscle biopsies taken after 5, 15, and 30 min of exercise showed only minor changes in the concentrations of glycogen, lactate, creatine phosphate (CrP), and ATP. However, at exhaustion, defined as loss of ability to sustain the target force, the concentrations of CrP and glycogen were reduced by 73 and 32%, and muscle lactate concentration had increased to 4.8 mmol/kg wet wt. Thus the gradual decline in force-generating capacity was not due to lactacidosis or lack of substrates for ATP resynthesis and must have resulted from excitation/contraction coupling failure, whereas exhaustion was closely related to phosphagen depletion, without significant lactacidosis.

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Crossref · 10.1152/jappl.1988.64.4.1421

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  • High-intensity intermittent exercise performed in a 5 s work/5 s recovery duty cycle is likely to be fuelled largely by muscle high-energy phosphate breakdown during work and resynthesis of high energy phosphates by oxidative phosphorylation during recovery.

    “and (2) ®ndings to suggest that high-intensity intermittent exercise performed in a 5 s work/5 s recovery duty cycle is likely to be fuelled largely by muscle high-energy phosphate breakdown during work and resynthesis of high energy phosphates by oxidative phosphorylation during recovery (Edwards et al. 1973, Vollestad et al. 1988).”

    From Slower fatigue and faster recovery of the adductor pollicis muscle in women matched for strength with men (1999) · cites this paper as Vollestad et al. 1988

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Authors
Vollestad, N. K., Sejersted, O. M., Bahr, R., Woods, J. J., & Bigland-Ritchie, B.
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1988-04-01
Volume
64
Issue
4
Pages
1421-1427
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1988.64.4.1421
OpenAlex
W2269573921
Cited by
172
References
20
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 5 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 5
FWCI
13.85
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL30062)
  • National Institute of Neurological Disorders and Stroke (NS 14576)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
Keywords
contractile failure, excitation-contraction coupling, muscle fatigue, quadriceps, isometric contraction, force-generating capacity, muscle lactate, muscle glycogen, ATP resynthesis, exercise exhaustion, submaximal exercise, muscle metabolism
MeSH terms
Adenosine Triphosphate, Central Nervous System, Electric Stimulation, Energy Metabolism, Physical Exertion, Fatigue, Female, Glycogen, Humans, Isometric Contraction, Lactates, Male, Muscle Contraction, Muscles, Phosphocreatine

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