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O2 cost of inspiratory and expiratory resistive breathing in humans
Abstract
In six normal male subjects we compared the O2 cost of resistive breathing (VO2 resp) between equivalent external inspiratory (IRL) and expiratory loads (ERL) studied separately. Each subject performed four pairs of runs matched for tidal volume, breathing frequency, flow rates, lung volume, pressure-time product, and work rate. Basal O2 uptake, measured before and after pairs of loaded runs, was subtracted from that measured during resistive breathing to obtain VO2 resp. For an equivalent load, the VO2 resp during ERL (184 +/- 17 ml O2/min) was nearly twice that obtained during IRL (97 +/- 9 ml O2/min). This twofold difference in efficiency between inspiratory and expiratory resistive breathing may reflect the relatively lower mechanical advantage of the expiratory muscles in overcoming respiratory loads. Variable recruitment of expiratory muscles may explain the large variation of results obtained in studies of respiratory muscle efficiency in normal subjects.
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“The net effect is a pronounced increase in the work and oxygen (O 2 ) cost of breathing at rest in patients with severe COPD [46].”
From Lung hyperinflation in COPD: applying physiology to clinical practice (2015) · cites this paper as [46]
In the citing paper
“The work and O 2 cost of breathing required to achieve a given increase in _ V E steadily increases to a high percentage of the total O 2 uptake [46].”
From Lung hyperinflation in COPD: applying physiology to clinical practice (2015) · cites this paper as [46]
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Cited by
Lung hyperinflation in COPD: applying physiology to clinical practice
O’Donnell, D. E., Webb, K. A., & Neder, J. A. (2015) · COPD Research and Practice · doi:10.1186/s40749-015-0008-8 · Cited by 93
Metadata
- Authors
- Dodd, D. S., Yarom, J., Loring, S. H., & Engel, L. A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1988-12-01
- Volume
- 65
- Issue
- 6
- Pages
- 2518-2523
- ISSN
- 8750-7587
- 1522-1601
- Cited by
- 19
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: O2 cost of inspiratory and expiratory resistive breathing in humans. https://app.cochat.ai/papers/10.1152/jappl.1988.65.6.2518
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- Dodd, D. S., Yarom, J., Loring, S. H., & Engel, L. A. (1988). O2 cost of inspiratory and expiratory resistive breathing in humans. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1988.65.6.2518
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
