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Quantitation of cerebral blood volume in human infants by near-infrared spectroscopy
Abstract
Current methods for measuring cerebral blood volume (CBV) in newborn infants are unsatisfactory. A new method is described in which the effect of a small change (5-10%) in arterial oxygen saturation (SaO2) on cerebral oxyhemoglobin [HbO2] and deoxyhemoglobin [Hb] concentration is observed by near-infrared (NIR) spectroscopy. Previous experiments in which the NIR absorption characteristics of HbO2 and Hb and the pathlength of NIR light through the brain were defined allowed changes in [HbO2] and [Hb] to be quantified from the Beer-Lambert law. It is shown here that CBV can then be derived from the expression CBV = (delta[HbO2] - delta[Hb])/(2. delta SaO2.H.R.), where H is the large vessel total hemoglobin concentration and R to the cerebral-to-large vessel hematocrit ratio. Observations on 12 newborn infants with normal brains, born at 25-40 wk of gestation and aged 10-240 h, gave a mean value for CBV of 2.22 +/- 0.40 (SD) ml/100 g, whereas mean CBV was significantly higher 3.00 +/- 1.04 ml/100 g in 10 infants with brain injury born at 24 to 42 wk of gestation and aged 4-168 h (P less than 0.05).
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Cited by
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Metadata
- Authors
- Wyatt, J. S., Cope, M., Delpy, D. T., Richardson, C. E., Edwards, A. D., Wray, S., & Reynolds, E. O.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1990-03-01
- Volume
- 68
- Issue
- 3
- Pages
- 1086-1091
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1908676835
- Cited by
- 442
- References
- 0
- FWCI
- 14.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wyatt, J. S., Cope, M., Delpy, D. T., Richardson, C. E., Edwards, A. D., Wray, S., & Reynolds, E. O. (1990). Quantitation of cerebral blood volume in human infants by near-infrared spectroscopy. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1990.68.3.1086
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